Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of <i>TMEM18</i> Polymorphisms Carriers
The transmembrane protein 18 (<i>TMEM18</i>) gene plays a central and peripheral role in weight regulation. <i>TMEM18</i> genetic polymorphisms have been identified as an important risk factor for obesity, depending on ethnic population and age. This research aimed to study t...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/2/266 |
| _version_ | 1797438153795043328 |
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| author | Danyel Chermon Ruth Birk |
| author_facet | Danyel Chermon Ruth Birk |
| author_sort | Danyel Chermon |
| collection | DOAJ |
| description | The transmembrane protein 18 (<i>TMEM18</i>) gene plays a central and peripheral role in weight regulation. <i>TMEM18</i> genetic polymorphisms have been identified as an important risk factor for obesity, depending on ethnic population and age. This research aimed to study the association of common <i>TMEM18</i> polymorphisms with obesity and their interactions with modifiable factors, namely drinking habits (sugar-sweetened beverages (SSBs), flavored water and wine) and physical activity (PA) in the Israeli population. Adults (n = 3089) were analyzed for common <i>TMEM18</i> polymorphisms and lifestyle and nutrition habits were obtained from questionnaires using adjusted (age, sex) binary logistic regression models. <i>TMEM18</i> rs939583 and rs1879523 were significantly associated with increased obesity risk (OR = 1.35, 95% CI (1.17–1.57) and OR = 1.66, 95% CI (1.29–2.15), respectively). <i>TMEM18</i> rs939583 interacted with consumption of 1–3 weekly glasses of wine and PA to attenuate obesity risk (OR = 0.82 95% CI (0.74–0.9; <i>p</i> < 0.001) and OR = 0.74 95% CI (0.68–0.8), respectively), while physical inactivity, SSBs and flavored water consumption significantly enhanced obesity risk (OR = 1.54 95% CI (1.41–1.67), OR = 1.31 95% CI (1.14–1.51) and OR = 1.35 95% CI (1.13–1.62), respectively). PA duration was significantly associated with a lower BMI for rs939583 risk carriers, with a PA cutoff of >30 min/week (<i>p</i> = 0.005) and >90 min/week (<i>p</i> = 0.01). Common <i>TMEM18</i> SNPs were significantly linked with adult obesity risk and interacted with modifiable lifestyle factors. |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:33:07Z |
| publishDate | 2023-01-01 |
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| series | Nutrients |
| spelling | doaj.art-f90146b2c74843bc94dbeaa7862696d52023-11-30T23:49:10ZengMDPI AGNutrients2072-66432023-01-0115226610.3390/nu15020266Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of <i>TMEM18</i> Polymorphisms CarriersDanyel Chermon0Ruth Birk1Nutrition Department, Health Science Faculty, Ariel University, Ariel 40700, IsraelNutrition Department, Health Science Faculty, Ariel University, Ariel 40700, IsraelThe transmembrane protein 18 (<i>TMEM18</i>) gene plays a central and peripheral role in weight regulation. <i>TMEM18</i> genetic polymorphisms have been identified as an important risk factor for obesity, depending on ethnic population and age. This research aimed to study the association of common <i>TMEM18</i> polymorphisms with obesity and their interactions with modifiable factors, namely drinking habits (sugar-sweetened beverages (SSBs), flavored water and wine) and physical activity (PA) in the Israeli population. Adults (n = 3089) were analyzed for common <i>TMEM18</i> polymorphisms and lifestyle and nutrition habits were obtained from questionnaires using adjusted (age, sex) binary logistic regression models. <i>TMEM18</i> rs939583 and rs1879523 were significantly associated with increased obesity risk (OR = 1.35, 95% CI (1.17–1.57) and OR = 1.66, 95% CI (1.29–2.15), respectively). <i>TMEM18</i> rs939583 interacted with consumption of 1–3 weekly glasses of wine and PA to attenuate obesity risk (OR = 0.82 95% CI (0.74–0.9; <i>p</i> < 0.001) and OR = 0.74 95% CI (0.68–0.8), respectively), while physical inactivity, SSBs and flavored water consumption significantly enhanced obesity risk (OR = 1.54 95% CI (1.41–1.67), OR = 1.31 95% CI (1.14–1.51) and OR = 1.35 95% CI (1.13–1.62), respectively). PA duration was significantly associated with a lower BMI for rs939583 risk carriers, with a PA cutoff of >30 min/week (<i>p</i> = 0.005) and >90 min/week (<i>p</i> = 0.01). Common <i>TMEM18</i> SNPs were significantly linked with adult obesity risk and interacted with modifiable lifestyle factors.https://www.mdpi.com/2072-6643/15/2/266Transmembrane protein 18single nucleotide polymorphismsobesitylifestylephysical activity |
| spellingShingle | Danyel Chermon Ruth Birk Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of <i>TMEM18</i> Polymorphisms Carriers Nutrients Transmembrane protein 18 single nucleotide polymorphisms obesity lifestyle physical activity |
| title | Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of <i>TMEM18</i> Polymorphisms Carriers |
| title_full | Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of <i>TMEM18</i> Polymorphisms Carriers |
| title_fullStr | Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of <i>TMEM18</i> Polymorphisms Carriers |
| title_full_unstemmed | Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of <i>TMEM18</i> Polymorphisms Carriers |
| title_short | Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of <i>TMEM18</i> Polymorphisms Carriers |
| title_sort | drinking habits and physical activity interact and attenuate obesity predisposition of i tmem18 i polymorphisms carriers |
| topic | Transmembrane protein 18 single nucleotide polymorphisms obesity lifestyle physical activity |
| url | https://www.mdpi.com/2072-6643/15/2/266 |
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