Inflammatory cytokines during a manic episode in bd patients and its correlation with cognitive and affective symptoms at follow-up
Introduction Bipolar Disorder (BD) is a severe recurrent disorder with a complex biogenetic and psychosocial etiology. The immune system cytokines in interaction with the CNS play a role in the pathophysiology. Objectives To compare inflammatory cytokines between BD patients and controls during...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821016606/type/journal_article |
| Summary: | Introduction
Bipolar Disorder (BD) is a severe recurrent disorder with a complex biogenetic and psychosocial etiology. The immune system cytokines in interaction with the CNS play a role in the pathophysiology.
Objectives
To compare inflammatory cytokines between BD patients and controls during the manic episode; additionally, compare these cytokines with psychiatric symptoms and cognitive performance during follow-up.
Methods
We recruited 25 BD patients in mania with paired controls. We measured baseline IL-2, IL-4, IL-8, IL-10, GM-CSG, TNF- α, and TNF- γ in plasma. We used U-Mann-Whitney for group comparison and Spearman correlation between sub-group follow-up assessments and cytokines.
Results
We found a significant difference in IL-6 between subjects and controls (figure 1). During the follow-up, we found a correlation with psychiatric symptoms, cognition, and cytokines during manic episodes (Table 1). Table 1. Follow-up Correlation with cytokines during a manic episode.
BD
follow-up N=8
Cytokine
MADRS
BPRS
SCIP-S
WMT-SCIP-S
PST-SCIP-S
IL-10
(-) Rho=-.957 (p=<0.001 R2=0.14).
IL-4
(+) Rho=.78 (p=0.02 R2=0.09)
INF- γ
(+) Rho=.73 (p=0.03 R2= 0.48)
(+) Rho=.751 (p=0.032 R2=0.53)
(+) Rho=.737 (p=.037 R2=0.40)
INF- α
(+) Rho=.887 (p=.003 R2=0.53),
(+) Rho=.830 (p=0.011 R2=0.59)
(+): positive correlation; (-): negative correlation. WMT: working-memory test, PST: Processing-speed test.
Conclusions
IL-6 was significantly different in patients with BD during a manic episode regardless of the treatment they were taking. IL-10 at manic episode was negatively correlated to general psychiatric symptoms, IL-4 positive correlated to depressive symptoms, and cognitive performance was positively correlated to TNF- α and TNF- γ at follow-up.
Disclosure
No significant relationships.
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| ISSN: | 0924-9338 1778-3585 |