Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model
Bone growth occurs in the epiphyseal growth plate (EGP) and epiphyseal growth plate cells (EGPCs) exist in EGP. EGPCs, including skeletal stem cells (SSCs), are cells that induce bone growth and development through endochondral ossification. Recently, the superiority of bone regeneration through end...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-08-01
|
| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/20417314221116754 |
| _version_ | 1828288110579941376 |
|---|---|
| author | Inho Baek Alvin Bacero Bello Jieun Jeon Yoshie Arai Byung-Hyun Cha Byoung Ju Kim Soo-Hong Lee |
| author_facet | Inho Baek Alvin Bacero Bello Jieun Jeon Yoshie Arai Byung-Hyun Cha Byoung Ju Kim Soo-Hong Lee |
| author_sort | Inho Baek |
| collection | DOAJ |
| description | Bone growth occurs in the epiphyseal growth plate (EGP) and epiphyseal growth plate cells (EGPCs) exist in EGP. EGPCs, including skeletal stem cells (SSCs), are cells that induce bone growth and development through endochondral ossification. Recently, the superiority of bone regeneration through endochondral ossification has been reported. Our study compared EGPCs with bone marrow-derived mesenchymal stem cells (BM-MSCs) and suggested the therapeutic potential of new bone regeneration. In this study, we analyzed the characteristics between EGPCs and BM-MSCs based on morphological characteristics and molecular profiles. EGPCs expressed chondrogenic and osteogenic markers higher than BM-MSCs. Additionally, in co-culture with BM-MSCs, EGPCs induced an increase in chondrogenic, osteogenic, and hypertrophic markers of BM-MSCs. Finally, EGPCs induced higher bone regeneration than BM-MSCs in the osteoporosis model. Overall, we suggest the possibility of EGPCs as cell therapy for effective bone regeneration. |
| first_indexed | 2024-04-13T09:59:00Z |
| format | Article |
| id | doaj.art-f902c90af323460bbfdaf58b4d200664 |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-04-13T09:59:00Z |
| publishDate | 2022-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-f902c90af323460bbfdaf58b4d2006642022-12-22T02:51:17ZengSAGE PublishingJournal of Tissue Engineering2041-73142022-08-011310.1177/20417314221116754Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis modelInho Baek0Alvin Bacero Bello1Jieun Jeon2Yoshie Arai3Byung-Hyun Cha4Byoung Ju Kim5Soo-Hong Lee6Department of Medical Biotechnology, Dongguk University, Goyang, Gyeonggi, Republic of KoreaDepartment of Medical Biotechnology, Dongguk University, Goyang, Gyeonggi, Republic of KoreaDepartment of Medical Biotechnology, Dongguk University, Goyang, Gyeonggi, Republic of KoreaDepartment of Medical Biotechnology, Dongguk University, Goyang, Gyeonggi, Republic of KoreaDivision of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, Republic of KoreaATEMs, Seoul, Republic of KoreaDepartment of Medical Biotechnology, Dongguk University, Goyang, Gyeonggi, Republic of KoreaBone growth occurs in the epiphyseal growth plate (EGP) and epiphyseal growth plate cells (EGPCs) exist in EGP. EGPCs, including skeletal stem cells (SSCs), are cells that induce bone growth and development through endochondral ossification. Recently, the superiority of bone regeneration through endochondral ossification has been reported. Our study compared EGPCs with bone marrow-derived mesenchymal stem cells (BM-MSCs) and suggested the therapeutic potential of new bone regeneration. In this study, we analyzed the characteristics between EGPCs and BM-MSCs based on morphological characteristics and molecular profiles. EGPCs expressed chondrogenic and osteogenic markers higher than BM-MSCs. Additionally, in co-culture with BM-MSCs, EGPCs induced an increase in chondrogenic, osteogenic, and hypertrophic markers of BM-MSCs. Finally, EGPCs induced higher bone regeneration than BM-MSCs in the osteoporosis model. Overall, we suggest the possibility of EGPCs as cell therapy for effective bone regeneration.https://doi.org/10.1177/20417314221116754 |
| spellingShingle | Inho Baek Alvin Bacero Bello Jieun Jeon Yoshie Arai Byung-Hyun Cha Byoung Ju Kim Soo-Hong Lee Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model Journal of Tissue Engineering |
| title | Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model |
| title_full | Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model |
| title_fullStr | Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model |
| title_full_unstemmed | Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model |
| title_short | Therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model |
| title_sort | therapeutic potential of epiphyseal growth plate cells for bone regeneration in an osteoporosis model |
| url | https://doi.org/10.1177/20417314221116754 |
| work_keys_str_mv | AT inhobaek therapeuticpotentialofepiphysealgrowthplatecellsforboneregenerationinanosteoporosismodel AT alvinbacerobello therapeuticpotentialofepiphysealgrowthplatecellsforboneregenerationinanosteoporosismodel AT jieunjeon therapeuticpotentialofepiphysealgrowthplatecellsforboneregenerationinanosteoporosismodel AT yoshiearai therapeuticpotentialofepiphysealgrowthplatecellsforboneregenerationinanosteoporosismodel AT byunghyuncha therapeuticpotentialofepiphysealgrowthplatecellsforboneregenerationinanosteoporosismodel AT byoungjukim therapeuticpotentialofepiphysealgrowthplatecellsforboneregenerationinanosteoporosismodel AT soohonglee therapeuticpotentialofepiphysealgrowthplatecellsforboneregenerationinanosteoporosismodel |