The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update
Thyroid cancer is the most common endocrine malignancy, with an increasing trend in the past decades. It has a variety of different histological subtypes, the most frequent one being differentiated thyroid cancer, which refers to papillary carcinoma, the most common histological type, followed by fo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/4/1075 |
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| author | Robert Aurelian Tiucă Oana Mirela Tiucă Ionela Maria Pașcanu |
| author_facet | Robert Aurelian Tiucă Oana Mirela Tiucă Ionela Maria Pașcanu |
| author_sort | Robert Aurelian Tiucă |
| collection | DOAJ |
| description | Thyroid cancer is the most common endocrine malignancy, with an increasing trend in the past decades. It has a variety of different histological subtypes, the most frequent one being differentiated thyroid cancer, which refers to papillary carcinoma, the most common histological type, followed by follicular carcinoma. Associations between genetic polymorphisms and thyroid cancer have been investigated over the years and are an intriguing topic for the scientific world. To date, the results of associations of single nucleotide polymorphisms, the most common genetic variations in the genome, with thyroid cancer have been inconsistent, but many promising results could potentially influence future research toward developing new targeted therapies and new prognostic biomarkers, thus consolidating a more personalized management for these patients. This review focuses on emphasizing the existing literature data regarding genetic polymorphisms investigated for their potential association with differentiated thyroid cancer and highlights the opportunity of using genetic variations as biomarkers of diagnosis and prognosis for thyroid cancer patients. |
| first_indexed | 2024-03-11T05:13:36Z |
| format | Article |
| id | doaj.art-f9031aace5604ed38d9d54c6db7b91f8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T05:13:36Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj.art-f9031aace5604ed38d9d54c6db7b91f82023-11-17T18:26:12ZengMDPI AGBiomedicines2227-90592023-04-01114107510.3390/biomedicines11041075The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 UpdateRobert Aurelian Tiucă0Oana Mirela Tiucă1Ionela Maria Pașcanu2Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, RomaniaDoctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, RomaniaDepartment of Endocrinology, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, RomaniaThyroid cancer is the most common endocrine malignancy, with an increasing trend in the past decades. It has a variety of different histological subtypes, the most frequent one being differentiated thyroid cancer, which refers to papillary carcinoma, the most common histological type, followed by follicular carcinoma. Associations between genetic polymorphisms and thyroid cancer have been investigated over the years and are an intriguing topic for the scientific world. To date, the results of associations of single nucleotide polymorphisms, the most common genetic variations in the genome, with thyroid cancer have been inconsistent, but many promising results could potentially influence future research toward developing new targeted therapies and new prognostic biomarkers, thus consolidating a more personalized management for these patients. This review focuses on emphasizing the existing literature data regarding genetic polymorphisms investigated for their potential association with differentiated thyroid cancer and highlights the opportunity of using genetic variations as biomarkers of diagnosis and prognosis for thyroid cancer patients.https://www.mdpi.com/2227-9059/11/4/1075thyroid cancerdifferentiated thyroid cancerthyroid cancer prognosismolecular biomarkerstargeted therapysingle nucleotide polymorphism |
| spellingShingle | Robert Aurelian Tiucă Oana Mirela Tiucă Ionela Maria Pașcanu The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update Biomedicines thyroid cancer differentiated thyroid cancer thyroid cancer prognosis molecular biomarkers targeted therapy single nucleotide polymorphism |
| title | The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update |
| title_full | The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update |
| title_fullStr | The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update |
| title_full_unstemmed | The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update |
| title_short | The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update |
| title_sort | role of genetic polymorphisms in differentiated thyroid cancer a 2023 update |
| topic | thyroid cancer differentiated thyroid cancer thyroid cancer prognosis molecular biomarkers targeted therapy single nucleotide polymorphism |
| url | https://www.mdpi.com/2227-9059/11/4/1075 |
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