Endocytosis and physiology: insights from Disabled-2 deficient mice

Endocytosis and physiology: insights from Disabled-2 deficient mice

ABSTRACTDisabled-2 (Dab2) is a clathrin and cargo binding endocytic adaptor protein, and cell biology studies revealed that Dab2 plays a role in cellular trafficking of a number of transmembrane receptors and signaling proteins. A PTB/PID domain located in the N-terminus of Dab2 binds the NPXY moti...

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Bibliographic Details
Main Authors: Wensi Tao, Robert Moore, Elizabeth R. Smith, Xiang-Xi Mike Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Apoptosis
Cholesterol
Endocytosis
Kidney
Liver
signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00129/full

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