Selenium deficiency and the effects of supplementation on preterm infants

Objective: This study aimed to review the literature about blood concentrations of selenium associated with gestational age, feeding, supplementation and related clinical features in preterm infants. Data sources: Systematic review in the following databases: MEDLINE, PubMed, Google academics,...

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Main Authors: Renata Germano B. O. N. Freitas, Roberto Jose N. Nogueira, Maria Angela R. G. M. Antonio, Antonio de Azevedo Barros-Filho, Gabriel Hessel
Format: Article
Language:English
Published: Sociedade de Pediatria de São Paulo 2014-03-01
Series:Revista Paulista de Pediatria
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822014000100126&lng=en&tlng=en
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author Renata Germano B. O. N. Freitas
Roberto Jose N. Nogueira
Maria Angela R. G. M. Antonio
Antonio de Azevedo Barros-Filho
Gabriel Hessel
author_facet Renata Germano B. O. N. Freitas
Roberto Jose N. Nogueira
Maria Angela R. G. M. Antonio
Antonio de Azevedo Barros-Filho
Gabriel Hessel
author_sort Renata Germano B. O. N. Freitas
collection DOAJ
description Objective: This study aimed to review the literature about blood concentrations of selenium associated with gestational age, feeding, supplementation and related clinical features in preterm infants. Data sources: Systematic review in the following databases: MEDLINE, PubMed, Google academics, SciELO. org, ScienceDirect (Elsevier) and CINAHL-Plus with Full Text (EBSCO). Articles published up to January 2013 with the keywords "selenium deficiency", "selenium supplementation", "neonates", "infants", "newborn" and "preterm infants" were selected. Data synthesis: The studies reported that low blood selenium levels are associated with increased risk of respiratory diseases. Preterm infants, especially with low birth weight, presented lower selenium levels. Selenium deficiency has also been associated with the use of oral infant formula, enteral and parenteral nutrition (with or without selenium addition). The optimal dose and length of selenium supplementation is not well-established, since they are based only on age group and selenium ingestion by breastfed children. Furthermore, the clinical status of the infant affected by conditions that may increase oxidative stress, and consequently, selenium requirements is not taken into account. Conclusions: Prematurity and low birth weight can contribute to low blood selenium in premature infants. Selenium supplementation seems to minimize or prevent clinical complications caused by prematurity.
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spelling doaj.art-f90436b9af5648bcb454b17826c48c822022-12-22T02:41:05ZengSociedade de Pediatria de São PauloRevista Paulista de Pediatria1984-04622014-03-0132112613510.1590/S0103-05822014000100019S0103-05822014000100126Selenium deficiency and the effects of supplementation on preterm infantsRenata Germano B. O. N. FreitasRoberto Jose N. NogueiraMaria Angela R. G. M. AntonioAntonio de Azevedo Barros-FilhoGabriel HesselObjective: This study aimed to review the literature about blood concentrations of selenium associated with gestational age, feeding, supplementation and related clinical features in preterm infants. Data sources: Systematic review in the following databases: MEDLINE, PubMed, Google academics, SciELO. org, ScienceDirect (Elsevier) and CINAHL-Plus with Full Text (EBSCO). Articles published up to January 2013 with the keywords "selenium deficiency", "selenium supplementation", "neonates", "infants", "newborn" and "preterm infants" were selected. Data synthesis: The studies reported that low blood selenium levels are associated with increased risk of respiratory diseases. Preterm infants, especially with low birth weight, presented lower selenium levels. Selenium deficiency has also been associated with the use of oral infant formula, enteral and parenteral nutrition (with or without selenium addition). The optimal dose and length of selenium supplementation is not well-established, since they are based only on age group and selenium ingestion by breastfed children. Furthermore, the clinical status of the infant affected by conditions that may increase oxidative stress, and consequently, selenium requirements is not taken into account. Conclusions: Prematurity and low birth weight can contribute to low blood selenium in premature infants. Selenium supplementation seems to minimize or prevent clinical complications caused by prematurity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822014000100126&lng=en&tlng=enrevision sistematicadeficiencia de seleniosuplementacion de seleniorecien nacidoprematuro
spellingShingle Renata Germano B. O. N. Freitas
Roberto Jose N. Nogueira
Maria Angela R. G. M. Antonio
Antonio de Azevedo Barros-Filho
Gabriel Hessel
Selenium deficiency and the effects of supplementation on preterm infants
Revista Paulista de Pediatria
revision sistematica
deficiencia de selenio
suplementacion de selenio
recien nacido
prematuro
title Selenium deficiency and the effects of supplementation on preterm infants
title_full Selenium deficiency and the effects of supplementation on preterm infants
title_fullStr Selenium deficiency and the effects of supplementation on preterm infants
title_full_unstemmed Selenium deficiency and the effects of supplementation on preterm infants
title_short Selenium deficiency and the effects of supplementation on preterm infants
title_sort selenium deficiency and the effects of supplementation on preterm infants
topic revision sistematica
deficiencia de selenio
suplementacion de selenio
recien nacido
prematuro
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822014000100126&lng=en&tlng=en
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