Why some people discount more than others: Baseline activation in the dorsal PFC mediates the link between COMT genotype and impatient choice

Why some people discount more than others: Baseline activation in the dorsal PFC mediates the link between COMT genotype and impatient choice

Individuals differ widely in how steeply they discount future rewards. The sources of these stable individual differences in delay discounting (DD) are largely unknown. One candidate is the COMT Val158Met polymorphism, known to modulate prefrontal dopamine levels and affect DD. To identify possible...

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Bibliographic Details
Main Authors: Lorena R. R. Gianotti, Bernd eFigner, Richard P. Ebstein, Daria eKnoch
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Neuroscience
Subjects:
individual differences
Intertemporal choice
COMT genotype
delay discounting
endophenotype
resting EEG
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00054/full

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