Mesona chinensis Benth polysaccharides alleviates liver injury by beneficial regulation of gut microbiota in cyclophosphamide-induced mice
There are a number of health benefits of Mesona chinensis Benth polysaccharide (MP), but little is known about its hepatoprotective effect and effect on gut microbiota composition in mice with liver damage induced by cyclophosphamide (CTX). This study indicated that MP supplementation effectively in...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000756 |
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| author | Yuzhen Hong Mingyue Shen Lixin Huang Ting Wu Jianhua Xie |
| author_facet | Yuzhen Hong Mingyue Shen Lixin Huang Ting Wu Jianhua Xie |
| author_sort | Yuzhen Hong |
| collection | DOAJ |
| description | There are a number of health benefits of Mesona chinensis Benth polysaccharide (MP), but little is known about its hepatoprotective effect and effect on gut microbiota composition in mice with liver damage induced by cyclophosphamide (CTX). This study indicated that MP supplementation effectively inhibited the production of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), enhanced liver antioxidant capacity and repaired liver damage in mice caused by CTX. The release of inflammatory cytokines in liver and the concentration of lipopolysaccharide (LPS) in serum were decreased, and the level of short chain fatty acids (SCFAs) in colon was increased after MP administration. Those effects may be correlated with the regulation of the gut microbiota. Importantly, MP restrained liver inflammatory responses induced by CTX may via increasing the SCFAs-producing bacteria family Ruminococcaceae and reduced LPS-producing bacteria genus Bacteroides. In short, the prevention of CTX-induced liver injury by supplementing MP is achieved at least in part by regulating the community structure of the gut microbiota, and MP is expected to be a potential prebiotic to treat and prevent liver diseases. |
| first_indexed | 2024-03-12T04:04:10Z |
| format | Article |
| id | doaj.art-f907a887dc474df39337f957c303169f |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T04:04:10Z |
| publishDate | 2022-01-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj.art-f907a887dc474df39337f957c303169f2023-09-03T11:27:32ZengTsinghua University PressFood Science and Human Wellness2213-45302022-01-011117484Mesona chinensis Benth polysaccharides alleviates liver injury by beneficial regulation of gut microbiota in cyclophosphamide-induced miceYuzhen Hong0Mingyue Shen1Lixin Huang2Ting Wu3Jianhua Xie4State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaCorresponding author at: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaThere are a number of health benefits of Mesona chinensis Benth polysaccharide (MP), but little is known about its hepatoprotective effect and effect on gut microbiota composition in mice with liver damage induced by cyclophosphamide (CTX). This study indicated that MP supplementation effectively inhibited the production of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), enhanced liver antioxidant capacity and repaired liver damage in mice caused by CTX. The release of inflammatory cytokines in liver and the concentration of lipopolysaccharide (LPS) in serum were decreased, and the level of short chain fatty acids (SCFAs) in colon was increased after MP administration. Those effects may be correlated with the regulation of the gut microbiota. Importantly, MP restrained liver inflammatory responses induced by CTX may via increasing the SCFAs-producing bacteria family Ruminococcaceae and reduced LPS-producing bacteria genus Bacteroides. In short, the prevention of CTX-induced liver injury by supplementing MP is achieved at least in part by regulating the community structure of the gut microbiota, and MP is expected to be a potential prebiotic to treat and prevent liver diseases.http://www.sciencedirect.com/science/article/pii/S2213453021000756Gut microbiotaLiver damageOxidative stressPolysaccharide |
| spellingShingle | Yuzhen Hong Mingyue Shen Lixin Huang Ting Wu Jianhua Xie Mesona chinensis Benth polysaccharides alleviates liver injury by beneficial regulation of gut microbiota in cyclophosphamide-induced mice Food Science and Human Wellness Gut microbiota Liver damage Oxidative stress Polysaccharide |
| title | Mesona chinensis Benth polysaccharides alleviates liver injury by beneficial regulation of gut microbiota in cyclophosphamide-induced mice |
| title_full | Mesona chinensis Benth polysaccharides alleviates liver injury by beneficial regulation of gut microbiota in cyclophosphamide-induced mice |
| title_fullStr | Mesona chinensis Benth polysaccharides alleviates liver injury by beneficial regulation of gut microbiota in cyclophosphamide-induced mice |
| title_full_unstemmed | Mesona chinensis Benth polysaccharides alleviates liver injury by beneficial regulation of gut microbiota in cyclophosphamide-induced mice |
| title_short | Mesona chinensis Benth polysaccharides alleviates liver injury by beneficial regulation of gut microbiota in cyclophosphamide-induced mice |
| title_sort | mesona chinensis benth polysaccharides alleviates liver injury by beneficial regulation of gut microbiota in cyclophosphamide induced mice |
| topic | Gut microbiota Liver damage Oxidative stress Polysaccharide |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000756 |
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