Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic
Abstract The chronic neurological aspects of traumatic brain injury, post‐stroke syndromes, long COVID‐19, persistent Lyme disease, and influenza encephalopathy having close pathophysiological parallels that warrant being investigated in an integrated manner. A mechanism, common to all, for this per...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-04-01
|
| Series: | Pharmacology Research & Perspectives |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/prp2.926 |
| _version_ | 1828339280226811904 |
|---|---|
| author | Ian Albert Clark |
| author_facet | Ian Albert Clark |
| author_sort | Ian Albert Clark |
| collection | DOAJ |
| description | Abstract The chronic neurological aspects of traumatic brain injury, post‐stroke syndromes, long COVID‐19, persistent Lyme disease, and influenza encephalopathy having close pathophysiological parallels that warrant being investigated in an integrated manner. A mechanism, common to all, for this persistence of the range of symptoms common to these conditions is described. While TNF maintains cerebral homeostasis, its excessive production through either pathogen‐associated molecular patterns or damage‐associated molecular patterns activity associates with the persistence of the symptoms common across both infectious and non‐infectious conditions. The case is made that this shared chronicity arises from a positive feedback loop causing the persistence of the activation of microglia by the TNF that these cells generate. Lowering this excess TNF is the logical way to reducing this persistent, TNF‐maintained, microglial activation. While too large to negotiate the blood‐brain barrier effectively, the specific anti‐TNF biological, etanercept, shows promise when administered by the perispinal route, which allows it to bypass this obstruction. |
| first_indexed | 2024-04-13T22:41:26Z |
| format | Article |
| id | doaj.art-f9088bf2a26841d896d7840cc2cf2a8e |
| institution | Directory Open Access Journal |
| issn | 2052-1707 |
| language | English |
| last_indexed | 2024-04-13T22:41:26Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pharmacology Research & Perspectives |
| spelling | doaj.art-f9088bf2a26841d896d7840cc2cf2a8e2022-12-22T02:26:37ZengWileyPharmacology Research & Perspectives2052-17072022-04-01102n/an/a10.1002/prp2.926Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logicIan Albert Clark0Research School of Biology Australian National University Canberra ACT AustraliaAbstract The chronic neurological aspects of traumatic brain injury, post‐stroke syndromes, long COVID‐19, persistent Lyme disease, and influenza encephalopathy having close pathophysiological parallels that warrant being investigated in an integrated manner. A mechanism, common to all, for this persistence of the range of symptoms common to these conditions is described. While TNF maintains cerebral homeostasis, its excessive production through either pathogen‐associated molecular patterns or damage‐associated molecular patterns activity associates with the persistence of the symptoms common across both infectious and non‐infectious conditions. The case is made that this shared chronicity arises from a positive feedback loop causing the persistence of the activation of microglia by the TNF that these cells generate. Lowering this excess TNF is the logical way to reducing this persistent, TNF‐maintained, microglial activation. While too large to negotiate the blood‐brain barrier effectively, the specific anti‐TNF biological, etanercept, shows promise when administered by the perispinal route, which allows it to bypass this obstruction.https://doi.org/10.1002/prp2.926chronicity of neurological deficitetanerceptfatiguelong COVIDpost‐stroke syndromestaste and smell |
| spellingShingle | Ian Albert Clark Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic Pharmacology Research & Perspectives chronicity of neurological deficit etanercept fatigue long COVID post‐stroke syndromes taste and smell |
| title | Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic |
| title_full | Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic |
| title_fullStr | Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic |
| title_full_unstemmed | Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic |
| title_short | Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic |
| title_sort | chronic cerebral aspects of long covid post stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic |
| topic | chronicity of neurological deficit etanercept fatigue long COVID post‐stroke syndromes taste and smell |
| url | https://doi.org/10.1002/prp2.926 |
| work_keys_str_mv | AT ianalbertclark chroniccerebralaspectsoflongcovidpoststrokesyndromesandsimilarstatessharetheirpathogenesisandperispinaletanercepttreatmentlogic |