Lipid Peroxidation in the Pre-Reactive Period of Cold Injury
Pathological processes in the pre-reactive period of cold injury have not been studied.The purpose of this study is to assess the morphological and biochemical parameters of blood in the body of patients in the pre-reactive period of cold injury.Material and methods. We examined patients with cold i...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2020-05-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/2302 |
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| author | V. M. Nikolaev S. I. Sofronova E. K. Rumyantsev Z. N. Alekseeva N. K. Chirikova N. A. Sleptsova S. A. Fedorova |
| author_facet | V. M. Nikolaev S. I. Sofronova E. K. Rumyantsev Z. N. Alekseeva N. K. Chirikova N. A. Sleptsova S. A. Fedorova |
| author_sort | V. M. Nikolaev |
| collection | DOAJ |
| description | Pathological processes in the pre-reactive period of cold injury have not been studied.The purpose of this study is to assess the morphological and biochemical parameters of blood in the body of patients in the pre-reactive period of cold injury.Material and methods. We examined patients with cold injury in the pre-reactive period. Determined: diene conjugates, malonic dialdehyde, the total content of low molecular weight antioxidants, superoxide dismutase activity, catalase,glutathione peroxidase, glutathione reductase, using a SPECORD 40 spectrophotometer. The serum biochemical parameters in the serum were determined by biochemical automator analysis. Statistical processing of the data was performed using IBM SPSS Statistics 19.Results and discussion. Features of the biochemical profile of blood in the pre-reactive period of cold injury in the human body are an increase in concentration of glucose and triacylglycerides in blood, an increase in transaminase activity, as aresult of inflammatory and destructive processes, a decrease in the cholesterol concentration in the blood of patients. At the same time, the pre-reactive period of cold injury is characterized by an increase in monocytes compared with the control, which, in combination with hypoxia, leads to an intensification of lipid peroxidation processes. In addition, the antioxidant protection in the pre-reactive period in the body of patients increased slightly.Conclusion. According to the results of our research, already at the stage of the pre-reactive period of cold injury there is a significant intensification of free radical lipid oxidation processes. |
| first_indexed | 2024-03-08T12:17:34Z |
| format | Article |
| id | doaj.art-f90c09d89ea64e87bcc46f39c82d5c62 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:16:38Z |
| publishDate | 2020-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-f90c09d89ea64e87bcc46f39c82d5c622024-03-28T07:49:23ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962020-05-015271110.29413/ABS.2020-5.2.12019Lipid Peroxidation in the Pre-Reactive Period of Cold InjuryV. M. Nikolaev0S. I. Sofronova1E. K. Rumyantsev2Z. N. Alekseeva3N. K. Chirikova4N. A. Sleptsova5S. A. Fedorova6Yakut Science Centre of Complex Medical ProblemsYakut Science Centre of Complex Medical ProblemsYakut Science Centre of Complex Medical ProblemsYakut Science Centre of Complex Medical ProblemsNorth-Eastern Federal University named after M.K. AmmosovYakutsk State Agricultural AcademyNorth-Eastern Federal University named after M.K. AmmosovPathological processes in the pre-reactive period of cold injury have not been studied.The purpose of this study is to assess the morphological and biochemical parameters of blood in the body of patients in the pre-reactive period of cold injury.Material and methods. We examined patients with cold injury in the pre-reactive period. Determined: diene conjugates, malonic dialdehyde, the total content of low molecular weight antioxidants, superoxide dismutase activity, catalase,glutathione peroxidase, glutathione reductase, using a SPECORD 40 spectrophotometer. The serum biochemical parameters in the serum were determined by biochemical automator analysis. Statistical processing of the data was performed using IBM SPSS Statistics 19.Results and discussion. Features of the biochemical profile of blood in the pre-reactive period of cold injury in the human body are an increase in concentration of glucose and triacylglycerides in blood, an increase in transaminase activity, as aresult of inflammatory and destructive processes, a decrease in the cholesterol concentration in the blood of patients. At the same time, the pre-reactive period of cold injury is characterized by an increase in monocytes compared with the control, which, in combination with hypoxia, leads to an intensification of lipid peroxidation processes. In addition, the antioxidant protection in the pre-reactive period in the body of patients increased slightly.Conclusion. According to the results of our research, already at the stage of the pre-reactive period of cold injury there is a significant intensification of free radical lipid oxidation processes.https://www.actabiomedica.ru/jour/article/view/2302pre-reactive periodfree radical lipid oxidationcold injury |
| spellingShingle | V. M. Nikolaev S. I. Sofronova E. K. Rumyantsev Z. N. Alekseeva N. K. Chirikova N. A. Sleptsova S. A. Fedorova Lipid Peroxidation in the Pre-Reactive Period of Cold Injury Acta Biomedica Scientifica pre-reactive period free radical lipid oxidation cold injury |
| title | Lipid Peroxidation in the Pre-Reactive Period of Cold Injury |
| title_full | Lipid Peroxidation in the Pre-Reactive Period of Cold Injury |
| title_fullStr | Lipid Peroxidation in the Pre-Reactive Period of Cold Injury |
| title_full_unstemmed | Lipid Peroxidation in the Pre-Reactive Period of Cold Injury |
| title_short | Lipid Peroxidation in the Pre-Reactive Period of Cold Injury |
| title_sort | lipid peroxidation in the pre reactive period of cold injury |
| topic | pre-reactive period free radical lipid oxidation cold injury |
| url | https://www.actabiomedica.ru/jour/article/view/2302 |
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