Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer
The connection between inflammation and tumorigenesis has been well established, based on a great deal of supporting evidence obtained from epidemiological, pharmacological, and genetic studies. One representative example is inflammatory bowel disease, because it is an important risk factor for the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/3/3/2811/ |
| _version_ | 1797715886268743680 |
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| author | Naofumi Mukaida So-ichiro Sasakki Boryana K. Popivanova |
| author_facet | Naofumi Mukaida So-ichiro Sasakki Boryana K. Popivanova |
| author_sort | Naofumi Mukaida |
| collection | DOAJ |
| description | The connection between inflammation and tumorigenesis has been well established, based on a great deal of supporting evidence obtained from epidemiological, pharmacological, and genetic studies. One representative example is inflammatory bowel disease, because it is an important risk factor for the development of colon cancer. Moreover, intratumoral infiltration of inflammatory cells suggests the involvement of inflammatory responses also in other forms of sporadic as well as heritable colon cancer. Inflammatory responses and tumorigenesis activate similar sets of transcription factors such as NF-kB, Stat3, and hypoxia inducible factor and eventually enhances the expression of inflammatory cytokines including tumor necrosis factor (TNF) and chemokines. The expression of TNF and chemokines is aberrantly expressed in a mouse model of colitis-associated carcinogenesis as well as in inflammatory bowel disease and colon cancer in humans. Here, after summarizing the presumed actions of TNF and chemokines in tumor biology, we will discuss the potential roles of TNF and chemokines in chronic inflammation-associated colon cancer in mice. |
| first_indexed | 2024-03-12T08:13:28Z |
| format | Article |
| id | doaj.art-f90d5302064b4e249650867d007b0734 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T08:13:28Z |
| publishDate | 2011-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f90d5302064b4e249650867d007b07342023-09-02T19:05:03ZengMDPI AGCancers2072-66942011-06-01332811282610.3390/cancers3032811Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated CancerNaofumi MukaidaSo-ichiro SasakkiBoryana K. PopivanovaThe connection between inflammation and tumorigenesis has been well established, based on a great deal of supporting evidence obtained from epidemiological, pharmacological, and genetic studies. One representative example is inflammatory bowel disease, because it is an important risk factor for the development of colon cancer. Moreover, intratumoral infiltration of inflammatory cells suggests the involvement of inflammatory responses also in other forms of sporadic as well as heritable colon cancer. Inflammatory responses and tumorigenesis activate similar sets of transcription factors such as NF-kB, Stat3, and hypoxia inducible factor and eventually enhances the expression of inflammatory cytokines including tumor necrosis factor (TNF) and chemokines. The expression of TNF and chemokines is aberrantly expressed in a mouse model of colitis-associated carcinogenesis as well as in inflammatory bowel disease and colon cancer in humans. Here, after summarizing the presumed actions of TNF and chemokines in tumor biology, we will discuss the potential roles of TNF and chemokines in chronic inflammation-associated colon cancer in mice.http://www.mdpi.com/2072-6694/3/3/2811/cyclooxygenase 2tumor-associated macrophageneovascularizationNF-kBhypoxia inducible factor |
| spellingShingle | Naofumi Mukaida So-ichiro Sasakki Boryana K. Popivanova Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer Cancers cyclooxygenase 2 tumor-associated macrophage neovascularization NF-kB hypoxia inducible factor |
| title | Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer |
| title_full | Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer |
| title_fullStr | Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer |
| title_full_unstemmed | Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer |
| title_short | Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer |
| title_sort | tumor necrosis factor tnf and chemokines in colitis associated cancer |
| topic | cyclooxygenase 2 tumor-associated macrophage neovascularization NF-kB hypoxia inducible factor |
| url | http://www.mdpi.com/2072-6694/3/3/2811/ |
| work_keys_str_mv | AT naofumimukaida tumornecrosisfactortnfandchemokinesincolitisassociatedcancer AT soichirosasakki tumornecrosisfactortnfandchemokinesincolitisassociatedcancer AT boryanakpopivanova tumornecrosisfactortnfandchemokinesincolitisassociatedcancer |