Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis
BackgroundIt is unclear whether the systemic inflammation response index (SIRI) can predict the prognosis of patients with hepatocellular carcinoma (HCC). Consequently, the present study focused on systematically identifying the relationship between SIRI and the prognosis of patients with HCC throug...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1291840/full |
| _version_ | 1797295248585523200 |
|---|---|
| author | Sunhuan Zhang Zhining Tang |
| author_facet | Sunhuan Zhang Zhining Tang |
| author_sort | Sunhuan Zhang |
| collection | DOAJ |
| description | BackgroundIt is unclear whether the systemic inflammation response index (SIRI) can predict the prognosis of patients with hepatocellular carcinoma (HCC). Consequently, the present study focused on systematically identifying the relationship between SIRI and the prognosis of patients with HCC through a meta-analysis.MethodsSystematic and comprehensive studies were retrieved from PubMed, Web of Science, Embase, and the Cochrane Library from their inception to August 10, 2023. The role of SIRI in predicting overall survival (OS) and progression-free survival (PFS) in HCC was determined using pooled hazard ratios (HRs) and 95% confidence intervals (CIs). Odds ratios (ORs) and 95% CIs were pooled to analyze the correlations between SIRI and the clinicopathological features of HCC.ResultsTen articles involving 2,439 patients were included. An elevated SIRI was significantly associated with dismal OS (HR=1.75, 95% CI=1.52–2.01, p<0.001) and inferior PFS (HR=1.66, 95% CI=1.34–2.05, p<0.001) in patients with HCC. Additionally, according to the combined results, the increased SIRI was significantly related to multiple tumor numbers (OR=1.42, 95% CI=1.09–1.85, p=0.009) and maximum tumor diameter >5 cm (OR=3.06, 95% CI=1.76–5.30, p<0.001). However, the SIRI did not show any significant relationship with sex, alpha-fetoprotein content, Child-Pugh class, or hepatitis B virus infection.ConclusionAccording to our results, elevated SIRI significantly predicted OS and PFS in patients with HCC. Moreover, the SIRI was significantly associated with tumor aggressiveness.Systematic review registrationhttps://inplasy.com/inplasy-2023-9-0003/, identifier INPLASY202390003. |
| first_indexed | 2024-03-07T21:44:01Z |
| format | Article |
| id | doaj.art-f90edad3d191430ab12aff5ed502385a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T21:44:01Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f90edad3d191430ab12aff5ed502385a2024-02-26T04:21:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.12918401291840Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysisSunhuan ZhangZhining TangBackgroundIt is unclear whether the systemic inflammation response index (SIRI) can predict the prognosis of patients with hepatocellular carcinoma (HCC). Consequently, the present study focused on systematically identifying the relationship between SIRI and the prognosis of patients with HCC through a meta-analysis.MethodsSystematic and comprehensive studies were retrieved from PubMed, Web of Science, Embase, and the Cochrane Library from their inception to August 10, 2023. The role of SIRI in predicting overall survival (OS) and progression-free survival (PFS) in HCC was determined using pooled hazard ratios (HRs) and 95% confidence intervals (CIs). Odds ratios (ORs) and 95% CIs were pooled to analyze the correlations between SIRI and the clinicopathological features of HCC.ResultsTen articles involving 2,439 patients were included. An elevated SIRI was significantly associated with dismal OS (HR=1.75, 95% CI=1.52–2.01, p<0.001) and inferior PFS (HR=1.66, 95% CI=1.34–2.05, p<0.001) in patients with HCC. Additionally, according to the combined results, the increased SIRI was significantly related to multiple tumor numbers (OR=1.42, 95% CI=1.09–1.85, p=0.009) and maximum tumor diameter >5 cm (OR=3.06, 95% CI=1.76–5.30, p<0.001). However, the SIRI did not show any significant relationship with sex, alpha-fetoprotein content, Child-Pugh class, or hepatitis B virus infection.ConclusionAccording to our results, elevated SIRI significantly predicted OS and PFS in patients with HCC. Moreover, the SIRI was significantly associated with tumor aggressiveness.Systematic review registrationhttps://inplasy.com/inplasy-2023-9-0003/, identifier INPLASY202390003.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1291840/fullSIRImeta-analysishepatocellular carcinomaprognosisevidence-based medicine |
| spellingShingle | Sunhuan Zhang Zhining Tang Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis Frontiers in Immunology SIRI meta-analysis hepatocellular carcinoma prognosis evidence-based medicine |
| title | Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis |
| title_full | Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis |
| title_fullStr | Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis |
| title_short | Prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma: a systematic review and meta-analysis |
| title_sort | prognostic and clinicopathological significance of systemic inflammation response index in patients with hepatocellular carcinoma a systematic review and meta analysis |
| topic | SIRI meta-analysis hepatocellular carcinoma prognosis evidence-based medicine |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1291840/full |
| work_keys_str_mv | AT sunhuanzhang prognosticandclinicopathologicalsignificanceofsystemicinflammationresponseindexinpatientswithhepatocellularcarcinomaasystematicreviewandmetaanalysis AT zhiningtang prognosticandclinicopathologicalsignificanceofsystemicinflammationresponseindexinpatientswithhepatocellularcarcinomaasystematicreviewandmetaanalysis |