Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence
In transplantation, donor and recipients frequently differ in age. Senescent cells accumulate in donor organs with aging and have the potential to promote senescence in adjacent cells when transferred into recipient animals. Characteristically, senescent cells secrete a myriad of pro-inflammatory, s...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-04-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.671479/full |
| _version_ | 1823928561909628928 |
|---|---|
| author | Jasper Iske Tomohisa Matsunaga Tomohisa Matsunaga Hao Zhou Stefan G. Tullius |
| author_facet | Jasper Iske Tomohisa Matsunaga Tomohisa Matsunaga Hao Zhou Stefan G. Tullius |
| author_sort | Jasper Iske |
| collection | DOAJ |
| description | In transplantation, donor and recipients frequently differ in age. Senescent cells accumulate in donor organs with aging and have the potential to promote senescence in adjacent cells when transferred into recipient animals. Characteristically, senescent cells secrete a myriad of pro-inflammatory, soluble molecules as part of their distinct secretory phenotype that have been shown to drive senescence and age-related co-morbidities. Preliminary own data show that the transplantation of old organs limits the physical reserve of recipient animals. Here, we review how organ age may affect transplant recipients and discuss the potential of accelerated aging. |
| first_indexed | 2024-12-16T20:56:27Z |
| format | Article |
| id | doaj.art-f910746e3a0243729e28fe20d69a44a8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T20:56:27Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f910746e3a0243729e28fe20d69a44a82022-12-21T22:16:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-04-011210.3389/fimmu.2021.671479671479Donor and Recipient Age-Mismatches: The Potential of Transferring SenescenceJasper Iske0Tomohisa Matsunaga1Tomohisa Matsunaga2Hao Zhou3Stefan G. Tullius4Division of Transplant Surgery & Transplant Surgery Research Laboratory, Brigham and Women´s Hospital, Harvard Medical School, Boston, MA, United StatesDivision of Transplant Surgery & Transplant Surgery Research Laboratory, Brigham and Women´s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Urology, Osaka Medical College, Osaka, JapanDivision of Transplant Surgery & Transplant Surgery Research Laboratory, Brigham and Women´s Hospital, Harvard Medical School, Boston, MA, United StatesDivision of Transplant Surgery & Transplant Surgery Research Laboratory, Brigham and Women´s Hospital, Harvard Medical School, Boston, MA, United StatesIn transplantation, donor and recipients frequently differ in age. Senescent cells accumulate in donor organs with aging and have the potential to promote senescence in adjacent cells when transferred into recipient animals. Characteristically, senescent cells secrete a myriad of pro-inflammatory, soluble molecules as part of their distinct secretory phenotype that have been shown to drive senescence and age-related co-morbidities. Preliminary own data show that the transplantation of old organs limits the physical reserve of recipient animals. Here, we review how organ age may affect transplant recipients and discuss the potential of accelerated aging.https://www.frontiersin.org/articles/10.3389/fimmu.2021.671479/fullimmunosenescence and inflammagingimmunosenescenceimmune agingsenescent cellpassenger leukocytessenescent associated secretory phenotype |
| spellingShingle | Jasper Iske Tomohisa Matsunaga Tomohisa Matsunaga Hao Zhou Stefan G. Tullius Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence Frontiers in Immunology immunosenescence and inflammaging immunosenescence immune aging senescent cell passenger leukocytes senescent associated secretory phenotype |
| title | Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence |
| title_full | Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence |
| title_fullStr | Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence |
| title_full_unstemmed | Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence |
| title_short | Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence |
| title_sort | donor and recipient age mismatches the potential of transferring senescence |
| topic | immunosenescence and inflammaging immunosenescence immune aging senescent cell passenger leukocytes senescent associated secretory phenotype |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.671479/full |
| work_keys_str_mv | AT jasperiske donorandrecipientagemismatchesthepotentialoftransferringsenescence AT tomohisamatsunaga donorandrecipientagemismatchesthepotentialoftransferringsenescence AT tomohisamatsunaga donorandrecipientagemismatchesthepotentialoftransferringsenescence AT haozhou donorandrecipientagemismatchesthepotentialoftransferringsenescence AT stefangtullius donorandrecipientagemismatchesthepotentialoftransferringsenescence |