Drug-Related Problems of Children With Chronic Diseases in a Chinese Primary Health Care Institution: A Cross-Sectional Study
Introduction: Drug-related problems (DRPs) refer to events or circumstances involving drug therapy that actually or potentially interfere with desired health outcomes. DRPs might be severe for children with chronic diseases managed at primary health care institutions, but the relevant research is sc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.874948/full |
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| author | Xiao-Feng Ni Xiao-Feng Ni Xiao-Feng Ni Xiao-Feng Ni Chun-Song Yang Chun-Song Yang Chun-Song Yang Li-Nan Zeng Li-Nan Zeng Li-Nan Zeng Hai-Long Li Hai-Long Li Hai-Long Li Sha Diao Sha Diao Sha Diao De-Yuan Li Jin Wu Yuan-Chun Liu Zhi-Jun Jia Zhi-Jun Jia Zhi-Jun Jia Zhi-Jun Jia Guo Cheng Guo Cheng Guo Cheng Ling-Li Zhang Ling-Li Zhang Ling-Li Zhang Ling-Li Zhang |
| author_facet | Xiao-Feng Ni Xiao-Feng Ni Xiao-Feng Ni Xiao-Feng Ni Chun-Song Yang Chun-Song Yang Chun-Song Yang Li-Nan Zeng Li-Nan Zeng Li-Nan Zeng Hai-Long Li Hai-Long Li Hai-Long Li Sha Diao Sha Diao Sha Diao De-Yuan Li Jin Wu Yuan-Chun Liu Zhi-Jun Jia Zhi-Jun Jia Zhi-Jun Jia Zhi-Jun Jia Guo Cheng Guo Cheng Guo Cheng Ling-Li Zhang Ling-Li Zhang Ling-Li Zhang Ling-Li Zhang |
| author_sort | Xiao-Feng Ni |
| collection | DOAJ |
| description | Introduction: Drug-related problems (DRPs) refer to events or circumstances involving drug therapy that actually or potentially interfere with desired health outcomes. DRPs might be severe for children with chronic diseases managed at primary health care institutions, but the relevant research is scarce.Objective: In this cross-sectional study, we aimed to explore the prevalence, types, causes, and influencing factors of DRPs in children with chronic diseases in a Chinese primary health care institution.Methods: We recruited children with chronic diseases who visited the pediatric outpatient department in a primary health care institution from July 1 to 12 October 2021. Clinical pharmacists identified DRPs through medication therapy reviews, classified the types and causes of DRPs, and distinguished the manifested DRPs that affected the outcome and potential DRPs that were going to affect the outcome.Results: A total of 188 children with chronic diseases was included, and 584 DRPs were identified in 89.89% of participants. The most common type of DRPs was “treatment effectiveness” (a manifested problem or potential problem with the effect of the pharmacotherapy; 83.56%), of which 67.29% were potential DRPs. The second common type was “treatment safety” (patient suffers or could suffer from an adverse drug event; 14.21%), of which 89.16% were potential DRPs. The most common cause of DRPs was related to the process of use (42.24%), such as “patient uses/takes less drug than prescribed or does not take the drug at all,” “patient stores drug inappropriately,” and “patient administers/uses the drug in a wrong way.” The second common cause was related to the process of dispensing (29.83%), such as “necessary information not provided or incorrect advice provided” and “prescribed drug is not available.” The third common cause was related to the process of prescribing (26.21%), such as “drug dose is too low” and “no or incomplete drug treatment despite an existing indication.” The number of combined medications was an influencing factor for the frequency of DRPs (p < 0.05).Conclusion: This cross-sectional study showed that the current situation regarding DRPs among children with chronic diseases managed in the primary health care institution was serious. The types of DRPs were mainly related to treatment effectiveness, and improper usage of medications was one of the main causes of DRPs. The number of combined drugs was the influencing factor for the frequency of DRPs. In the future, pharmacists should consider formulating pharmaceutical intervention strategies for this specific group according to the characteristics of DRPs. |
| first_indexed | 2024-04-13T05:33:31Z |
| format | Article |
| id | doaj.art-f910c216fe7742c1bb234cf129aa7f19 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T05:33:31Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-f910c216fe7742c1bb234cf129aa7f192022-12-22T03:00:22ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-07-011310.3389/fphar.2022.874948874948Drug-Related Problems of Children With Chronic Diseases in a Chinese Primary Health Care Institution: A Cross-Sectional StudyXiao-Feng Ni0Xiao-Feng Ni1Xiao-Feng Ni2Xiao-Feng Ni3Chun-Song Yang4Chun-Song Yang5Chun-Song Yang6Li-Nan Zeng7Li-Nan Zeng8Li-Nan Zeng9Hai-Long Li10Hai-Long Li11Hai-Long Li12Sha Diao13Sha Diao14Sha Diao15De-Yuan Li16Jin Wu17Yuan-Chun Liu18Zhi-Jun Jia19Zhi-Jun Jia20Zhi-Jun Jia21Zhi-Jun Jia22Guo Cheng23Guo Cheng24Guo Cheng25Ling-Li Zhang26Ling-Li Zhang27Ling-Li Zhang28Ling-Li Zhang29Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education (Sichuan University), Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education (Sichuan University), Chengdu, ChinaDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education (Sichuan University), Chengdu, ChinaDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education (Sichuan University), Chengdu, ChinaDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education (Sichuan University), Chengdu, ChinaPediatric Intensive Care, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaZigong Da’an Maternity and, Child Health Care Hospital, Zigong, ChinaDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education (Sichuan University), Chengdu, ChinaWest China School of Pharmacy, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education (Sichuan University), Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaLaboratory of Molecular Translational Medicine, Center for Translational Medicine, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education (Sichuan University), Chengdu, China0China Center for Evidence-based Medicine, West China Hospital, Sichuan University, Chengdu, ChinaIntroduction: Drug-related problems (DRPs) refer to events or circumstances involving drug therapy that actually or potentially interfere with desired health outcomes. DRPs might be severe for children with chronic diseases managed at primary health care institutions, but the relevant research is scarce.Objective: In this cross-sectional study, we aimed to explore the prevalence, types, causes, and influencing factors of DRPs in children with chronic diseases in a Chinese primary health care institution.Methods: We recruited children with chronic diseases who visited the pediatric outpatient department in a primary health care institution from July 1 to 12 October 2021. Clinical pharmacists identified DRPs through medication therapy reviews, classified the types and causes of DRPs, and distinguished the manifested DRPs that affected the outcome and potential DRPs that were going to affect the outcome.Results: A total of 188 children with chronic diseases was included, and 584 DRPs were identified in 89.89% of participants. The most common type of DRPs was “treatment effectiveness” (a manifested problem or potential problem with the effect of the pharmacotherapy; 83.56%), of which 67.29% were potential DRPs. The second common type was “treatment safety” (patient suffers or could suffer from an adverse drug event; 14.21%), of which 89.16% were potential DRPs. The most common cause of DRPs was related to the process of use (42.24%), such as “patient uses/takes less drug than prescribed or does not take the drug at all,” “patient stores drug inappropriately,” and “patient administers/uses the drug in a wrong way.” The second common cause was related to the process of dispensing (29.83%), such as “necessary information not provided or incorrect advice provided” and “prescribed drug is not available.” The third common cause was related to the process of prescribing (26.21%), such as “drug dose is too low” and “no or incomplete drug treatment despite an existing indication.” The number of combined medications was an influencing factor for the frequency of DRPs (p < 0.05).Conclusion: This cross-sectional study showed that the current situation regarding DRPs among children with chronic diseases managed in the primary health care institution was serious. The types of DRPs were mainly related to treatment effectiveness, and improper usage of medications was one of the main causes of DRPs. The number of combined drugs was the influencing factor for the frequency of DRPs. In the future, pharmacists should consider formulating pharmaceutical intervention strategies for this specific group according to the characteristics of DRPs.https://www.frontiersin.org/articles/10.3389/fphar.2022.874948/fulldrug-related problemsprimary heath carechildrenchronic diseasecross-sectional studyChina |
| spellingShingle | Xiao-Feng Ni Xiao-Feng Ni Xiao-Feng Ni Xiao-Feng Ni Chun-Song Yang Chun-Song Yang Chun-Song Yang Li-Nan Zeng Li-Nan Zeng Li-Nan Zeng Hai-Long Li Hai-Long Li Hai-Long Li Sha Diao Sha Diao Sha Diao De-Yuan Li Jin Wu Yuan-Chun Liu Zhi-Jun Jia Zhi-Jun Jia Zhi-Jun Jia Zhi-Jun Jia Guo Cheng Guo Cheng Guo Cheng Ling-Li Zhang Ling-Li Zhang Ling-Li Zhang Ling-Li Zhang Drug-Related Problems of Children With Chronic Diseases in a Chinese Primary Health Care Institution: A Cross-Sectional Study Frontiers in Pharmacology drug-related problems primary heath care children chronic disease cross-sectional study China |
| title | Drug-Related Problems of Children With Chronic Diseases in a Chinese Primary Health Care Institution: A Cross-Sectional Study |
| title_full | Drug-Related Problems of Children With Chronic Diseases in a Chinese Primary Health Care Institution: A Cross-Sectional Study |
| title_fullStr | Drug-Related Problems of Children With Chronic Diseases in a Chinese Primary Health Care Institution: A Cross-Sectional Study |
| title_full_unstemmed | Drug-Related Problems of Children With Chronic Diseases in a Chinese Primary Health Care Institution: A Cross-Sectional Study |
| title_short | Drug-Related Problems of Children With Chronic Diseases in a Chinese Primary Health Care Institution: A Cross-Sectional Study |
| title_sort | drug related problems of children with chronic diseases in a chinese primary health care institution a cross sectional study |
| topic | drug-related problems primary heath care children chronic disease cross-sectional study China |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.874948/full |
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