Campylobacter jejuni Strains from Patients with Guillain-Barré Syndrome
Guillain-Barré syndrome (GBS), an acute demyelinating peripheral neuropathy, may be triggered by an acute infectious illness; infection with Campylobacter jejuni is the most frequently reported antecedent event. In Japan, O:19 is the most common serotype among GBS-associated C. jejuni strains. To de...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
1998-06-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/4/2/98-0213_article |
| _version_ | 1818968822242082816 |
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| author | Ban Mishu Allos Frank T. Lippy Andrea Carlsen Ronald G. Washburn Martin J. Blaser |
| author_facet | Ban Mishu Allos Frank T. Lippy Andrea Carlsen Ronald G. Washburn Martin J. Blaser |
| author_sort | Ban Mishu Allos |
| collection | DOAJ |
| description | Guillain-Barré syndrome (GBS), an acute demyelinating peripheral neuropathy, may be triggered by an acute infectious illness; infection with Campylobacter jejuni is the most frequently reported antecedent event. In Japan, O:19 is the most common serotype among GBS-associated C. jejuni strains. To determine whether serotype O:19 occurs among GBS-associated strains in the United States and Europe, we serotyped seven such strains and found that two (29%) of seven GBS-associated strains from patients in the United States and Germany were serotype O:19. To determine whether GBS-associated strains may be resistant to killing by normal human serum (NHS), we studied the serum susceptibility of 17 GBS- and 27 enteritis-associated strains (including many O:19 and non-O:19 strains) using C. jejuni antibody positive (pool 1) or negative (pool 2) human serum. Using pool 1 serum we found that one (6%) of 18 serotype O:19 strains compared with 11 (42%) of 26 non-O:19 strains were killed; results using pool 2 serum were nearly identical. Finally, 8 O:19 and 8 non-O:19 strains were not significantly different in their ability to bind complement component C3. Serotype O:19 C. jejuni strains were overrepresented among GBS-associated strains in the United States and Germany and were significantly more serum-resistant than non-O:19 strains. The mechanism of this resistance appears unrelated to C3 binding. |
| first_indexed | 2024-12-20T14:10:48Z |
| format | Article |
| id | doaj.art-f9126b52aad449d4b6aa3e5bbdacf0fc |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-20T14:10:48Z |
| publishDate | 1998-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-f9126b52aad449d4b6aa3e5bbdacf0fc2022-12-21T19:38:09ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60591998-06-014226326810.3201/eid0402.980213Campylobacter jejuni Strains from Patients with Guillain-Barré SyndromeBan Mishu AllosFrank T. LippyAndrea CarlsenRonald G. WashburnMartin J. BlaserGuillain-Barré syndrome (GBS), an acute demyelinating peripheral neuropathy, may be triggered by an acute infectious illness; infection with Campylobacter jejuni is the most frequently reported antecedent event. In Japan, O:19 is the most common serotype among GBS-associated C. jejuni strains. To determine whether serotype O:19 occurs among GBS-associated strains in the United States and Europe, we serotyped seven such strains and found that two (29%) of seven GBS-associated strains from patients in the United States and Germany were serotype O:19. To determine whether GBS-associated strains may be resistant to killing by normal human serum (NHS), we studied the serum susceptibility of 17 GBS- and 27 enteritis-associated strains (including many O:19 and non-O:19 strains) using C. jejuni antibody positive (pool 1) or negative (pool 2) human serum. Using pool 1 serum we found that one (6%) of 18 serotype O:19 strains compared with 11 (42%) of 26 non-O:19 strains were killed; results using pool 2 serum were nearly identical. Finally, 8 O:19 and 8 non-O:19 strains were not significantly different in their ability to bind complement component C3. Serotype O:19 C. jejuni strains were overrepresented among GBS-associated strains in the United States and Germany and were significantly more serum-resistant than non-O:19 strains. The mechanism of this resistance appears unrelated to C3 binding.https://wwwnc.cdc.gov/eid/article/4/2/98-0213_articleUnited States |
| spellingShingle | Ban Mishu Allos Frank T. Lippy Andrea Carlsen Ronald G. Washburn Martin J. Blaser Campylobacter jejuni Strains from Patients with Guillain-Barré Syndrome Emerging Infectious Diseases United States |
| title | Campylobacter jejuni Strains from Patients with Guillain-Barré Syndrome |
| title_full | Campylobacter jejuni Strains from Patients with Guillain-Barré Syndrome |
| title_fullStr | Campylobacter jejuni Strains from Patients with Guillain-Barré Syndrome |
| title_full_unstemmed | Campylobacter jejuni Strains from Patients with Guillain-Barré Syndrome |
| title_short | Campylobacter jejuni Strains from Patients with Guillain-Barré Syndrome |
| title_sort | campylobacter jejuni strains from patients with guillain barre syndrome |
| topic | United States |
| url | https://wwwnc.cdc.gov/eid/article/4/2/98-0213_article |
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