Therapeutic Strategies against Ebola Virus Infection
Since the 2014–2016 epidemic, Ebola virus (EBOV) has spread to several countries and has become a major threat to global health. EBOV is a risk group 4 pathogen, which imposes significant obstacles for the development of countermeasures against the virus. Efforts have been made to develop anti-EBOV...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/3/579 |
| _version_ | 1827624775990640640 |
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| author | Ching-Hsuan Liu Yee-Tung Hu Shu Hui Wong Liang-Tzung Lin |
| author_facet | Ching-Hsuan Liu Yee-Tung Hu Shu Hui Wong Liang-Tzung Lin |
| author_sort | Ching-Hsuan Liu |
| collection | DOAJ |
| description | Since the 2014–2016 epidemic, Ebola virus (EBOV) has spread to several countries and has become a major threat to global health. EBOV is a risk group 4 pathogen, which imposes significant obstacles for the development of countermeasures against the virus. Efforts have been made to develop anti-EBOV immunization and therapeutics, with three vaccines and two antibody-based therapeutics approved in recent years. Nonetheless, the high fatality of Ebola virus disease highlights the need to continuously develop antiviral strategies for the future management of EBOV outbreaks in conjunction with vaccination programs. This review aims to highlight potential EBOV therapeutics and their target(s) of inhibition, serving as a summary of the literature to inform readers of the novel candidates available in the continued search for EBOV antivirals. |
| first_indexed | 2024-03-09T12:16:23Z |
| format | Article |
| id | doaj.art-f912e9c3f94e4fdaa7ac589d9b033f8c |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T12:16:23Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f912e9c3f94e4fdaa7ac589d9b033f8c2023-11-30T22:46:36ZengMDPI AGViruses1999-49152022-03-0114357910.3390/v14030579Therapeutic Strategies against Ebola Virus InfectionChing-Hsuan Liu0Yee-Tung Hu1Shu Hui Wong2Liang-Tzung Lin3Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, TaiwanInternational Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanSince the 2014–2016 epidemic, Ebola virus (EBOV) has spread to several countries and has become a major threat to global health. EBOV is a risk group 4 pathogen, which imposes significant obstacles for the development of countermeasures against the virus. Efforts have been made to develop anti-EBOV immunization and therapeutics, with three vaccines and two antibody-based therapeutics approved in recent years. Nonetheless, the high fatality of Ebola virus disease highlights the need to continuously develop antiviral strategies for the future management of EBOV outbreaks in conjunction with vaccination programs. This review aims to highlight potential EBOV therapeutics and their target(s) of inhibition, serving as a summary of the literature to inform readers of the novel candidates available in the continued search for EBOV antivirals.https://www.mdpi.com/1999-4915/14/3/579Ebola virusEbola virus diseaseantiviraltherapeuticdrug development |
| spellingShingle | Ching-Hsuan Liu Yee-Tung Hu Shu Hui Wong Liang-Tzung Lin Therapeutic Strategies against Ebola Virus Infection Viruses Ebola virus Ebola virus disease antiviral therapeutic drug development |
| title | Therapeutic Strategies against Ebola Virus Infection |
| title_full | Therapeutic Strategies against Ebola Virus Infection |
| title_fullStr | Therapeutic Strategies against Ebola Virus Infection |
| title_full_unstemmed | Therapeutic Strategies against Ebola Virus Infection |
| title_short | Therapeutic Strategies against Ebola Virus Infection |
| title_sort | therapeutic strategies against ebola virus infection |
| topic | Ebola virus Ebola virus disease antiviral therapeutic drug development |
| url | https://www.mdpi.com/1999-4915/14/3/579 |
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