APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC

APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC

Abstract Background Triple negative breast cancer (TNBC) is a breast cancer subgroup characterized by a lack of hormone receptors’ expression and no HER2 overexpression. These molecular features both drastically reduce treatment options and confer poor prognosis. Platinum (Pt)-salts are being invest...

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Bibliographic Details
Main Authors: Matilde Clarissa Malfatti, Lorenzo Gerratana, Emiliano Dalla, Miriam Isola, Giuseppe Damante, Carla Di Loreto, Fabio Puglisi, Gianluca Tell
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TNBC
APE1
NPM1
Platinum salts
APE1-inhibitors
TCGA
Online Access:http://link.springer.com/article/10.1186/s13046-019-1294-9

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