Diet and Physical Activity in Fabry Disease: A Narrative Review
Fabry disease (FD) is caused by mutations in the galactosidase alpha (GLA) gene which lead to the accumulation of globotriaosylceramide (Gb-3). Enzyme replacement therapy (ERT) and oral chaperone therapy are the current pharmacological treatments for this condition. However, in the literature, there...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-04-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/16/7/1061 |
| _version_ | 1797212201305505792 |
|---|---|
| author | Giovanna Muscogiuri Oriana De Marco Tonia Di Lorenzo Maria Amicone Ivana Capuano Eleonora Riccio Guido Iaccarino Antonio Bianco Teodolinda Di Risi Antonio Pisani |
| author_facet | Giovanna Muscogiuri Oriana De Marco Tonia Di Lorenzo Maria Amicone Ivana Capuano Eleonora Riccio Guido Iaccarino Antonio Bianco Teodolinda Di Risi Antonio Pisani |
| author_sort | Giovanna Muscogiuri |
| collection | DOAJ |
| description | Fabry disease (FD) is caused by mutations in the galactosidase alpha (GLA) gene which lead to the accumulation of globotriaosylceramide (Gb-3). Enzyme replacement therapy (ERT) and oral chaperone therapy are the current pharmacological treatments for this condition. However, in the literature, there is a growing emphasis on exploring non-pharmacological therapeutic strategies to improve the quality of life of patients with FD. In particular, the nutritional approach to FD has been marginally addressed in the scientific literature, although specific dietary interventions may be useful for the management of nephropathy and gastrointestinal complications, which are often present in patients with FD. Especially in cases of confirmed diagnosis of irritable bowel syndrome (IBS), a low-FODMAP diet can represent an effective approach to improving intestinal manifestations. Furthermore, it is known that some food components, such as polyphenols, may be able to modulate some pathogenetic mechanisms underlying the disease, such as inflammation and oxidative stress. Therefore, the use of healthy dietary patterns should be encouraged in this patient group. Sports practice can be useful for patients with multi-organ involvement, particularly in cardiovascular, renal, and neurological aspects. Therefore, the aim of this review is to summarize current knowledge on the role of nutrition and physical activity in FD patients. |
| first_indexed | 2024-04-24T10:38:37Z |
| format | Article |
| id | doaj.art-f91409285f7f4b37aeda135c7120e79c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-24T10:38:37Z |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f91409285f7f4b37aeda135c7120e79c2024-04-12T13:24:30ZengMDPI AGNutrients2072-66432024-04-01167106110.3390/nu16071061Diet and Physical Activity in Fabry Disease: A Narrative ReviewGiovanna Muscogiuri0Oriana De Marco1Tonia Di Lorenzo2Maria Amicone3Ivana Capuano4Eleonora Riccio5Guido Iaccarino6Antonio Bianco7Teodolinda Di Risi8Antonio Pisani9Unità di Endocrinologia, Dipartimento di Medicina Clinica e Chirurgia, Diabetologia ed Andrologia, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, ItalyChair of Nephrology “Federico II”, Department of Public Health, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, ItalyEndocrinology Unit, Centro Italiano per la Cura e il Benessere del Paziente con Obesità (C.I.B.O), Department of Clinical Medicine and Surgery, University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, ItalyChair of Nephrology “Federico II”, Department of Public Health, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, ItalyChair of Nephrology “Federico II”, Department of Public Health, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, ItalyInstitute for Biomedical Research and Innovation, National Research Council of Italy, 90146 Palermo, ItalyInterdepartmental Research Center for Arterial Hypertension and Associated Pathologies (CIRIAPA)-Hypertension Research Center, University of Naples “Federico II”, 80131 Naples, ItalyInterdepartmental Research Center for Arterial Hypertension and Associated Pathologies (CIRIAPA)-Hypertension Research Center, University of Naples “Federico II”, 80131 Naples, ItalyChair of Nephrology “Federico II”, Department of Public Health, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, ItalyChair of Nephrology “Federico II”, Department of Public Health, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, ItalyFabry disease (FD) is caused by mutations in the galactosidase alpha (GLA) gene which lead to the accumulation of globotriaosylceramide (Gb-3). Enzyme replacement therapy (ERT) and oral chaperone therapy are the current pharmacological treatments for this condition. However, in the literature, there is a growing emphasis on exploring non-pharmacological therapeutic strategies to improve the quality of life of patients with FD. In particular, the nutritional approach to FD has been marginally addressed in the scientific literature, although specific dietary interventions may be useful for the management of nephropathy and gastrointestinal complications, which are often present in patients with FD. Especially in cases of confirmed diagnosis of irritable bowel syndrome (IBS), a low-FODMAP diet can represent an effective approach to improving intestinal manifestations. Furthermore, it is known that some food components, such as polyphenols, may be able to modulate some pathogenetic mechanisms underlying the disease, such as inflammation and oxidative stress. Therefore, the use of healthy dietary patterns should be encouraged in this patient group. Sports practice can be useful for patients with multi-organ involvement, particularly in cardiovascular, renal, and neurological aspects. Therefore, the aim of this review is to summarize current knowledge on the role of nutrition and physical activity in FD patients.https://www.mdpi.com/2072-6643/16/7/1061Fabry diseasephysical activityinflammationnutritional therapyoxidative stressFODMAPs |
| spellingShingle | Giovanna Muscogiuri Oriana De Marco Tonia Di Lorenzo Maria Amicone Ivana Capuano Eleonora Riccio Guido Iaccarino Antonio Bianco Teodolinda Di Risi Antonio Pisani Diet and Physical Activity in Fabry Disease: A Narrative Review Nutrients Fabry disease physical activity inflammation nutritional therapy oxidative stress FODMAPs |
| title | Diet and Physical Activity in Fabry Disease: A Narrative Review |
| title_full | Diet and Physical Activity in Fabry Disease: A Narrative Review |
| title_fullStr | Diet and Physical Activity in Fabry Disease: A Narrative Review |
| title_full_unstemmed | Diet and Physical Activity in Fabry Disease: A Narrative Review |
| title_short | Diet and Physical Activity in Fabry Disease: A Narrative Review |
| title_sort | diet and physical activity in fabry disease a narrative review |
| topic | Fabry disease physical activity inflammation nutritional therapy oxidative stress FODMAPs |
| url | https://www.mdpi.com/2072-6643/16/7/1061 |
| work_keys_str_mv | AT giovannamuscogiuri dietandphysicalactivityinfabrydiseaseanarrativereview AT orianademarco dietandphysicalactivityinfabrydiseaseanarrativereview AT toniadilorenzo dietandphysicalactivityinfabrydiseaseanarrativereview AT mariaamicone dietandphysicalactivityinfabrydiseaseanarrativereview AT ivanacapuano dietandphysicalactivityinfabrydiseaseanarrativereview AT eleonorariccio dietandphysicalactivityinfabrydiseaseanarrativereview AT guidoiaccarino dietandphysicalactivityinfabrydiseaseanarrativereview AT antoniobianco dietandphysicalactivityinfabrydiseaseanarrativereview AT teodolindadirisi dietandphysicalactivityinfabrydiseaseanarrativereview AT antoniopisani dietandphysicalactivityinfabrydiseaseanarrativereview |