A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice

A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice

IntroductionVaccinations are ideal for reducing the severity of clinical manifestations and secondary complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, SARS-CoV-2 continues to cause morbidity and mortality worldwide. In contrast to parenteral vaccines such as me...

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Bibliographic Details
Main Authors: Nagisa Tokunoh, Shigeyuki Tamiya, Masato Watanabe, Toru Okamoto, Jessica Anindita, Hiroki Tanaka, Chikako Ono, Toshiro Hirai, Hidetaka Akita, Yoshiharu Matsuura, Yasuo Yoshioka
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
antigen
IgA
inactivated whole-virion
messenger RNA vaccine
nasal vaccine
SARS-CoV-2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1224634/full

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