A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers
Mapping transcription factors (TFs) occupancy is essential for understanding transcriptional programs. Here the authors use biotinylated knockin alleles of key cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to map their genome-wide occupancy in the fetal and adult mouse heart, providing...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12812-3 |
| _version_ | 1818979187869876224 |
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| author | Brynn N. Akerberg Fei Gu Nathan J. VanDusen Xiaoran Zhang Rui Dong Kai Li Bing Zhang Bin Zhou Isha Sethi Qing Ma Lauren Wasson Tong Wen Jinhua Liu Kunzhe Dong Frank L. Conlon Jiliang Zhou Guo-Cheng Yuan Pingzhu Zhou William T. Pu |
| author_facet | Brynn N. Akerberg Fei Gu Nathan J. VanDusen Xiaoran Zhang Rui Dong Kai Li Bing Zhang Bin Zhou Isha Sethi Qing Ma Lauren Wasson Tong Wen Jinhua Liu Kunzhe Dong Frank L. Conlon Jiliang Zhou Guo-Cheng Yuan Pingzhu Zhou William T. Pu |
| author_sort | Brynn N. Akerberg |
| collection | DOAJ |
| description | Mapping transcription factors (TFs) occupancy is essential for understanding transcriptional programs. Here the authors use biotinylated knockin alleles of key cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to map their genome-wide occupancy in the fetal and adult mouse heart, providing insight into the cardiac transcriptional regulatory network. |
| first_indexed | 2024-12-20T16:55:33Z |
| format | Article |
| id | doaj.art-f91597d9ab8045b0bc0e2854890b31e1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:55:33Z |
| publishDate | 2019-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f91597d9ab8045b0bc0e2854890b31e12022-12-21T19:32:45ZengNature PortfolioNature Communications2041-17232019-10-0110111610.1038/s41467-019-12812-3A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancersBrynn N. Akerberg0Fei Gu1Nathan J. VanDusen2Xiaoran Zhang3Rui Dong4Kai Li5Bing Zhang6Bin Zhou7Isha Sethi8Qing Ma9Lauren Wasson10Tong Wen11Jinhua Liu12Kunzhe Dong13Frank L. Conlon14Jiliang Zhou15Guo-Cheng Yuan16Pingzhu Zhou17William T. Pu18Department of Cardiology, Boston Children’s HospitalDepartment of Cardiology, Boston Children’s HospitalDepartment of Cardiology, Boston Children’s HospitalDepartment of Cardiology, Boston Children’s HospitalDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer InstituteDepartment of Cardiology, Boston Children’s HospitalXin Hua Hospital, Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong UniversityInstitute of Biochemistry and Cell Biology, Shanghai Institutes for Biological SciencesDepartment of Cardiology, Boston Children’s HospitalDepartment of Cardiology, Boston Children’s HospitalBiology Department, University of North Carolina at Chapel HillDepartment of Cardiology, The First Affiliated Hospital of Nanchang UniversityDepartment of Respiratory Medicine, The First Affiliated Hospital of Nanchang UniversityDepartment of Pharmacology & Toxicology, Medical College of Georgia, Augusta UniversityBiology Department, University of North Carolina at Chapel HillDepartment of Pharmacology & Toxicology, Medical College of Georgia, Augusta UniversityDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer InstituteDepartment of Cardiology, Boston Children’s HospitalDepartment of Cardiology, Boston Children’s HospitalMapping transcription factors (TFs) occupancy is essential for understanding transcriptional programs. Here the authors use biotinylated knockin alleles of key cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to map their genome-wide occupancy in the fetal and adult mouse heart, providing insight into the cardiac transcriptional regulatory network.https://doi.org/10.1038/s41467-019-12812-3 |
| spellingShingle | Brynn N. Akerberg Fei Gu Nathan J. VanDusen Xiaoran Zhang Rui Dong Kai Li Bing Zhang Bin Zhou Isha Sethi Qing Ma Lauren Wasson Tong Wen Jinhua Liu Kunzhe Dong Frank L. Conlon Jiliang Zhou Guo-Cheng Yuan Pingzhu Zhou William T. Pu A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers Nature Communications |
| title | A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers |
| title_full | A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers |
| title_fullStr | A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers |
| title_full_unstemmed | A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers |
| title_short | A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers |
| title_sort | reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers |
| url | https://doi.org/10.1038/s41467-019-12812-3 |
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