The Oxidative Stress of Mercaptan Odorant Due to Occupational Exposure: Adverse Effects on the Cholinergic System
Background: Tert-butyl mercaptan is one of the frequently used odorants derived from natural gases. It has been declared as a health hazard by the Occupational Safety and Health Administration (OSHA) in the USA. There is not much information available about the mercaptans long-term toxicity secondar...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Arak University of Medical Sciences
2022-05-01
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| Series: | Iranian Journal of Toxicology |
| Subjects: | |
| Online Access: | http://ijt.arakmu.ac.ir/article-1-1010-en.html |
| _version_ | 1818278635148148736 |
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| author | Rezvan Zendehdel Shirin Seyed Ghoreyshi Fatemeh Rajabi Zohreh Amini Majid Mahdian Dehkordi Hakimeh Nouri Parkestani |
| author_facet | Rezvan Zendehdel Shirin Seyed Ghoreyshi Fatemeh Rajabi Zohreh Amini Majid Mahdian Dehkordi Hakimeh Nouri Parkestani |
| author_sort | Rezvan Zendehdel |
| collection | DOAJ |
| description | Background: Tert-butyl mercaptan is one of the frequently used odorants derived from natural gases. It has been declared as a health hazard by the Occupational Safety and Health Administration (OSHA) in the USA. There is not much information available about the mercaptans long-term toxicity secondary to occupational exposure. This study was conducted to evaluate the oxidative stress caused by mercaptan odorant.
Methods: The inhalation exposure of 80 maintenance workers in a gas industry was evaluated, using NIOSH 2542 and samples analyzed by gas chromatography mass spectroscopy. Also, the administrative staff were selected as the unexposed workers with matching age and work experience compared to the exposed subjects. The lipid peroxidation and ferric reducing plasma ability (FRAP), was evaluated as oxidative stress biomarkers. The acetylcholinesterase activity was also assessed for the neurological risks.
Results: The tert-butyl mercaptan exposure was evaluated at average 0.01 ppm (0.005 to 0.15 ppm). There was oxidative stress in maintenance workers along with a significant increase in the lipid peroxidation, and a decrease in FRAP level (P=0.0001). The acetyl cholinesterase activity was decreased in over half of the exposed subjects, and correlated significantly with the tert-butyl mercaptan level (r=-0.4, P=0.026).
Conclusion: There was a correlation between the inhibition of acetyl cholinesterase activity and the induction of oxidative stress. Based on the findings, the chronic occupational exposure to tert-butyl mercaptan was identified as a health hazard. Therefore, specific health care strategies should be developed to minimize the toxic effect of this chemical. |
| first_indexed | 2024-12-12T23:20:34Z |
| format | Article |
| id | doaj.art-f9159de8db5c4798af0ad0bcfe183242 |
| institution | Directory Open Access Journal |
| issn | 2008-2967 2251-9459 |
| language | English |
| last_indexed | 2024-12-12T23:20:34Z |
| publishDate | 2022-05-01 |
| publisher | Arak University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Toxicology |
| spelling | doaj.art-f9159de8db5c4798af0ad0bcfe1832422022-12-22T00:08:17ZengArak University of Medical SciencesIranian Journal of Toxicology2008-29672251-94592022-05-011629198The Oxidative Stress of Mercaptan Odorant Due to Occupational Exposure: Adverse Effects on the Cholinergic SystemRezvan Zendehdel0Shirin Seyed Ghoreyshi1Fatemeh Rajabi2Zohreh Amini3Majid Mahdian Dehkordi4Hakimeh Nouri Parkestani5 Department of Occupational Health, Engineering and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Occupational Health, Engineering and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Occupational Health, Engineering and Safety, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Research and Development, Chaharmahal & Bakhtiyari Province Gas Company, Shahr-e-kord, Iran. Department of Research and Development, Chaharmahal & Bakhtiyari Province Gas Company, Shahr-e-kord, Iran. Department of Research and Development, Chaharmahal & Bakhtiyari Province Gas Company, Shahr-e-kord, Iran. Background: Tert-butyl mercaptan is one of the frequently used odorants derived from natural gases. It has been declared as a health hazard by the Occupational Safety and Health Administration (OSHA) in the USA. There is not much information available about the mercaptans long-term toxicity secondary to occupational exposure. This study was conducted to evaluate the oxidative stress caused by mercaptan odorant. Methods: The inhalation exposure of 80 maintenance workers in a gas industry was evaluated, using NIOSH 2542 and samples analyzed by gas chromatography mass spectroscopy. Also, the administrative staff were selected as the unexposed workers with matching age and work experience compared to the exposed subjects. The lipid peroxidation and ferric reducing plasma ability (FRAP), was evaluated as oxidative stress biomarkers. The acetylcholinesterase activity was also assessed for the neurological risks. Results: The tert-butyl mercaptan exposure was evaluated at average 0.01 ppm (0.005 to 0.15 ppm). There was oxidative stress in maintenance workers along with a significant increase in the lipid peroxidation, and a decrease in FRAP level (P=0.0001). The acetyl cholinesterase activity was decreased in over half of the exposed subjects, and correlated significantly with the tert-butyl mercaptan level (r=-0.4, P=0.026). Conclusion: There was a correlation between the inhibition of acetyl cholinesterase activity and the induction of oxidative stress. Based on the findings, the chronic occupational exposure to tert-butyl mercaptan was identified as a health hazard. Therefore, specific health care strategies should be developed to minimize the toxic effect of this chemical.http://ijt.arakmu.ac.ir/article-1-1010-en.htmlnatural gasoccupational exposureoil and gas industryoxidative stresssulfhydryl compounds |
| spellingShingle | Rezvan Zendehdel Shirin Seyed Ghoreyshi Fatemeh Rajabi Zohreh Amini Majid Mahdian Dehkordi Hakimeh Nouri Parkestani The Oxidative Stress of Mercaptan Odorant Due to Occupational Exposure: Adverse Effects on the Cholinergic System Iranian Journal of Toxicology natural gas occupational exposure oil and gas industry oxidative stress sulfhydryl compounds |
| title | The Oxidative Stress of Mercaptan Odorant Due to Occupational Exposure: Adverse Effects on the Cholinergic System |
| title_full | The Oxidative Stress of Mercaptan Odorant Due to Occupational Exposure: Adverse Effects on the Cholinergic System |
| title_fullStr | The Oxidative Stress of Mercaptan Odorant Due to Occupational Exposure: Adverse Effects on the Cholinergic System |
| title_full_unstemmed | The Oxidative Stress of Mercaptan Odorant Due to Occupational Exposure: Adverse Effects on the Cholinergic System |
| title_short | The Oxidative Stress of Mercaptan Odorant Due to Occupational Exposure: Adverse Effects on the Cholinergic System |
| title_sort | oxidative stress of mercaptan odorant due to occupational exposure adverse effects on the cholinergic system |
| topic | natural gas occupational exposure oil and gas industry oxidative stress sulfhydryl compounds |
| url | http://ijt.arakmu.ac.ir/article-1-1010-en.html |
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