New Anticandidous 2-Alkylthio-6-aminobenzothiazoles
The synthesis and antimicrobial activity of six new 2-alkenyl-6-aminobenzothiazoles are reported. The new compounds were prepared by alkenylation of the potassium salt of 6-amino-2-mercaptobenzothiazole with alkenyl bromides. The structure of the compounds was verified by 1H NMR spectra. The compoun...
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| Format: | Article |
| Language: | English |
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MDPI AG
1997-02-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/2/2/36/ |
| _version_ | 1818556939464867840 |
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| author | Jana Kallová Helena Bujdáková Dusan Loos Eva Sidóová |
| author_facet | Jana Kallová Helena Bujdáková Dusan Loos Eva Sidóová |
| author_sort | Jana Kallová |
| collection | DOAJ |
| description | The synthesis and antimicrobial activity of six new 2-alkenyl-6-aminobenzothiazoles are reported. The new compounds were prepared by alkenylation of the potassium salt of 6-amino-2-mercaptobenzothiazole with alkenyl bromides. The structure of the compounds was verified by 1H NMR spectra. The compounds have shown antibacterial activity against Staphylococcus aureus and anticandidous activity against Candida albicans. The optimum structure of the studied compounds has been calculated by quantum chemistry AM1 method. The theoretical values of lipophilicity were calculated for all alkenyl substituents. |
| first_indexed | 2024-12-13T23:53:40Z |
| format | Article |
| id | doaj.art-f915bd928fb84e3e95765ba1abb4dba5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T23:53:40Z |
| publishDate | 1997-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f915bd928fb84e3e95765ba1abb4dba52022-12-21T23:26:41ZengMDPI AGMolecules1420-30491997-02-0122364210.3390/feb97p2New Anticandidous 2-Alkylthio-6-aminobenzothiazolesJana KallováHelena BujdákováDusan LoosEva SidóováThe synthesis and antimicrobial activity of six new 2-alkenyl-6-aminobenzothiazoles are reported. The new compounds were prepared by alkenylation of the potassium salt of 6-amino-2-mercaptobenzothiazole with alkenyl bromides. The structure of the compounds was verified by 1H NMR spectra. The compounds have shown antibacterial activity against Staphylococcus aureus and anticandidous activity against Candida albicans. The optimum structure of the studied compounds has been calculated by quantum chemistry AM1 method. The theoretical values of lipophilicity were calculated for all alkenyl substituents.http://www.mdpi.com/1420-3049/2/2/36/2-Alkenylthio-6-aminobenzothiazolesanticandidousantibacterialAM1 calculationslipophilicity |
| spellingShingle | Jana Kallová Helena Bujdáková Dusan Loos Eva Sidóová New Anticandidous 2-Alkylthio-6-aminobenzothiazoles Molecules 2-Alkenylthio-6-aminobenzothiazoles anticandidous antibacterial AM1 calculations lipophilicity |
| title | New Anticandidous 2-Alkylthio-6-aminobenzothiazoles |
| title_full | New Anticandidous 2-Alkylthio-6-aminobenzothiazoles |
| title_fullStr | New Anticandidous 2-Alkylthio-6-aminobenzothiazoles |
| title_full_unstemmed | New Anticandidous 2-Alkylthio-6-aminobenzothiazoles |
| title_short | New Anticandidous 2-Alkylthio-6-aminobenzothiazoles |
| title_sort | new anticandidous 2 alkylthio 6 aminobenzothiazoles |
| topic | 2-Alkenylthio-6-aminobenzothiazoles anticandidous antibacterial AM1 calculations lipophilicity |
| url | http://www.mdpi.com/1420-3049/2/2/36/ |
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