Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease
Abstract Background Alterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum levels of miR-483-5p is correlated with cardiometabolic risk factors and in...
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-021-01964-0 |
| _version_ | 1818623906191245312 |
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| author | Widet Gallo Filip Ottosson Cecilia Kennbäck Amra Jujic Jonathan Lou S. Esguerra Lena Eliasson Olle Melander |
| author_facet | Widet Gallo Filip Ottosson Cecilia Kennbäck Amra Jujic Jonathan Lou S. Esguerra Lena Eliasson Olle Melander |
| author_sort | Widet Gallo |
| collection | DOAJ |
| description | Abstract Background Alterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum levels of miR-483-5p is correlated with cardiometabolic risk factors and incidence of cardiometabolic disease in a case–control sample from the populations-based Malmö Diet and Cancer Study Cardiovascular Cohort (MDC-CC). We here aimed at replicating these findings and to test for association with carotid atherosclerosis. Methods We measured miR-483-5p in fasting serum of 1223 healthy subjects from the baseline examination of the population-based, prospective cohort study Malmö Offspring Study (MOS) and correlated miR-483-5p to cardiometabolic risk factors and to incidence of diabetes mellitus and coronary artery disease (CAD) during 3.7 (± 1.3) years of follow-up using logistic regression. In both MOS and MDC-CC we related mir-483-5p to carotid atherosclerosis measured with ultrasound. Results In cross-sectional analysis miR-483-5p was correlated with BMI, waist circumference, HDL, and sex. After adjustment for age and sex, the association remained significant for all risk factors except for HDL. Logistic regression analysis showed significant associations between miR-483-5p and new-onset diabetes (OR = 1.94, 95% CI 1.06–3.56, p = 0.032) and cardiovascular disease (OR = 1.99, 95% CI 1.06–3.75, p = 0.033) during 3.7 (± 1.3) years of follow-up. Furthermore, miR-483-5p was significantly related with maximum intima-media thickness of the carotid bulb in MDC-CC (p = 0.001), but not in MOS, whereas it was associated with increasing number of plaques in MOS (p = 0.007). Conclusion miR-483-5p is related to an unfavorable cardiometabolic risk factor profile and predicts diabetes and CAD, possibly through an effect on atherosclerosis. Our results encourage further studies of possible underlying mechanisms and means of modifying miR-483-5p as a possible interventional target in prevention of cardiometabolic disease. |
| first_indexed | 2024-12-16T18:48:30Z |
| format | Article |
| id | doaj.art-f915fbe55a294f0dbbfd7d6d77ca52c0 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-16T18:48:30Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-f915fbe55a294f0dbbfd7d6d77ca52c02022-12-21T22:20:45ZengBMCBMC Cardiovascular Disorders1471-22612021-04-012111710.1186/s12872-021-01964-0Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic diseaseWidet Gallo0Filip Ottosson1Cecilia Kennbäck2Amra Jujic3Jonathan Lou S. Esguerra4Lena Eliasson5Olle Melander6Department of Clinical Sciences-Malmö, Hypertension and Cardiovascular Disease, Lund UniversityDepartment of Clinical Sciences-Malmö, Hypertension and Cardiovascular Disease, Lund UniversityDepartment of Emergency and Internal Medicine, Skane University HospitalDepartment of Clinical Sciences-Malmö, Hypertension and Cardiovascular Disease, Lund UniversityDepartment of Clinical Sciences Malmö, Lund University Diabetes Centre, Lund University MalmöDepartment of Clinical Sciences Malmö, Lund University Diabetes Centre, Lund University MalmöDepartment of Clinical Sciences-Malmö, Hypertension and Cardiovascular Disease, Lund UniversityAbstract Background Alterations in levels of circulating micro-RNAs might reflect within organ signaling or subclinical tissue injury that is linked to risk of diabetes and cardiovascular risk. We previously found that serum levels of miR-483-5p is correlated with cardiometabolic risk factors and incidence of cardiometabolic disease in a case–control sample from the populations-based Malmö Diet and Cancer Study Cardiovascular Cohort (MDC-CC). We here aimed at replicating these findings and to test for association with carotid atherosclerosis. Methods We measured miR-483-5p in fasting serum of 1223 healthy subjects from the baseline examination of the population-based, prospective cohort study Malmö Offspring Study (MOS) and correlated miR-483-5p to cardiometabolic risk factors and to incidence of diabetes mellitus and coronary artery disease (CAD) during 3.7 (± 1.3) years of follow-up using logistic regression. In both MOS and MDC-CC we related mir-483-5p to carotid atherosclerosis measured with ultrasound. Results In cross-sectional analysis miR-483-5p was correlated with BMI, waist circumference, HDL, and sex. After adjustment for age and sex, the association remained significant for all risk factors except for HDL. Logistic regression analysis showed significant associations between miR-483-5p and new-onset diabetes (OR = 1.94, 95% CI 1.06–3.56, p = 0.032) and cardiovascular disease (OR = 1.99, 95% CI 1.06–3.75, p = 0.033) during 3.7 (± 1.3) years of follow-up. Furthermore, miR-483-5p was significantly related with maximum intima-media thickness of the carotid bulb in MDC-CC (p = 0.001), but not in MOS, whereas it was associated with increasing number of plaques in MOS (p = 0.007). Conclusion miR-483-5p is related to an unfavorable cardiometabolic risk factor profile and predicts diabetes and CAD, possibly through an effect on atherosclerosis. Our results encourage further studies of possible underlying mechanisms and means of modifying miR-483-5p as a possible interventional target in prevention of cardiometabolic disease.https://doi.org/10.1186/s12872-021-01964-0MiR-483-5pCardiometabolic diseaseAtherosclerosisDiabetes mellitus |
| spellingShingle | Widet Gallo Filip Ottosson Cecilia Kennbäck Amra Jujic Jonathan Lou S. Esguerra Lena Eliasson Olle Melander Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease BMC Cardiovascular Disorders MiR-483-5p Cardiometabolic disease Atherosclerosis Diabetes mellitus |
| title | Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease |
| title_full | Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease |
| title_fullStr | Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease |
| title_full_unstemmed | Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease |
| title_short | Replication study reveals miR-483-5p as an important target in prevention of cardiometabolic disease |
| title_sort | replication study reveals mir 483 5p as an important target in prevention of cardiometabolic disease |
| topic | MiR-483-5p Cardiometabolic disease Atherosclerosis Diabetes mellitus |
| url | https://doi.org/10.1186/s12872-021-01964-0 |
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