Stage-Specific Value of Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Serum Levels on Survival and Recurrence in Pancreatic Cancer: A Single Center Study and Meta-Analysis
This study aimed to determine the stage-specific prognostic value of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) serum levels at diagnosis on overall survival (OS) and time to local recurrence or distant metastases in patients with pancreatic ductal adenocarcinoma (PDAC). C...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/10/2970 |
| _version_ | 1797551103928172544 |
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| author | Labrinus van Manen Jesse V. Groen Hein Putter Martin Pichler Alexander L. Vahrmeijer Bert A. Bonsing J. Sven D. Mieog |
| author_facet | Labrinus van Manen Jesse V. Groen Hein Putter Martin Pichler Alexander L. Vahrmeijer Bert A. Bonsing J. Sven D. Mieog |
| author_sort | Labrinus van Manen |
| collection | DOAJ |
| description | This study aimed to determine the stage-specific prognostic value of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) serum levels at diagnosis on overall survival (OS) and time to local recurrence or distant metastases in patients with pancreatic ductal adenocarcinoma (PDAC). Consecutive PDAC patients, discussed at multidisciplinary team meetings from 2013 through 2017, were reviewed. Prognostic factors were stage-specific (resection vs. advanced PDAC) evaluated in Cox proportional hazard models. Additionally, a systematic literature search and meta-analysis was performed, as current literature is lacking a complete overview of used cut-off values and the added value of CEA as prognostic marker. In the retrospective cohort, elevated CA19-9 (>305 kU/L) level was independently associated with poor OS (Hazard ratio (HR): 1.72(1.31–2.26)) and early recurrence (HR: 1.74(1.06–2.86)), whereas CEA was not significantly associated. The meta-analysis showed that both elevated CA19-9 and CEA serum levels were predictors for poor OS (pooled HR: 1.29(1.17–1.42) and HR: 1.51(1.33–1.73), respectively). In the resected cohort, elevated CA19-9 level was significantly associated with early recurrence (pooled HR: 2.41(1.77–3.29)), whereas CEA was not. Elevated CA19-9 serum level appear to be an independent prognostic factor for poor OS and early recurrence in PDAC patients, whereas the prognostic value of CEA is disputable. |
| first_indexed | 2024-03-10T15:39:03Z |
| format | Article |
| id | doaj.art-f916083c8c3b43c39d9d99ad6cfb4c1c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:39:03Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f916083c8c3b43c39d9d99ad6cfb4c1c2023-11-20T16:59:52ZengMDPI AGCancers2072-66942020-10-011210297010.3390/cancers12102970Stage-Specific Value of Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Serum Levels on Survival and Recurrence in Pancreatic Cancer: A Single Center Study and Meta-AnalysisLabrinus van Manen0Jesse V. Groen1Hein Putter2Martin Pichler3Alexander L. Vahrmeijer4Bert A. Bonsing5J. Sven D. Mieog6Department of Surgery, Leiden University Medical Center, 2300RC Leiden, The NetherlandsDepartment of Surgery, Leiden University Medical Center, 2300RC Leiden, The NetherlandsDepartment of Medical Statistics, Leiden University Medical Center, 2300RC Leiden, The NetherlandsDivision of Clinical Oncology, Medical University of Graz, 8036 Graz, AustriaDepartment of Surgery, Leiden University Medical Center, 2300RC Leiden, The NetherlandsDepartment of Surgery, Leiden University Medical Center, 2300RC Leiden, The NetherlandsDepartment of Surgery, Leiden University Medical Center, 2300RC Leiden, The NetherlandsThis study aimed to determine the stage-specific prognostic value of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) serum levels at diagnosis on overall survival (OS) and time to local recurrence or distant metastases in patients with pancreatic ductal adenocarcinoma (PDAC). Consecutive PDAC patients, discussed at multidisciplinary team meetings from 2013 through 2017, were reviewed. Prognostic factors were stage-specific (resection vs. advanced PDAC) evaluated in Cox proportional hazard models. Additionally, a systematic literature search and meta-analysis was performed, as current literature is lacking a complete overview of used cut-off values and the added value of CEA as prognostic marker. In the retrospective cohort, elevated CA19-9 (>305 kU/L) level was independently associated with poor OS (Hazard ratio (HR): 1.72(1.31–2.26)) and early recurrence (HR: 1.74(1.06–2.86)), whereas CEA was not significantly associated. The meta-analysis showed that both elevated CA19-9 and CEA serum levels were predictors for poor OS (pooled HR: 1.29(1.17–1.42) and HR: 1.51(1.33–1.73), respectively). In the resected cohort, elevated CA19-9 level was significantly associated with early recurrence (pooled HR: 2.41(1.77–3.29)), whereas CEA was not. Elevated CA19-9 serum level appear to be an independent prognostic factor for poor OS and early recurrence in PDAC patients, whereas the prognostic value of CEA is disputable.https://www.mdpi.com/2072-6694/12/10/2970pancreatic neoplasmscarcinoembryonic antigencarbohydrate antigen 19.9survivalrecurrence |
| spellingShingle | Labrinus van Manen Jesse V. Groen Hein Putter Martin Pichler Alexander L. Vahrmeijer Bert A. Bonsing J. Sven D. Mieog Stage-Specific Value of Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Serum Levels on Survival and Recurrence in Pancreatic Cancer: A Single Center Study and Meta-Analysis Cancers pancreatic neoplasms carcinoembryonic antigen carbohydrate antigen 19.9 survival recurrence |
| title | Stage-Specific Value of Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Serum Levels on Survival and Recurrence in Pancreatic Cancer: A Single Center Study and Meta-Analysis |
| title_full | Stage-Specific Value of Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Serum Levels on Survival and Recurrence in Pancreatic Cancer: A Single Center Study and Meta-Analysis |
| title_fullStr | Stage-Specific Value of Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Serum Levels on Survival and Recurrence in Pancreatic Cancer: A Single Center Study and Meta-Analysis |
| title_full_unstemmed | Stage-Specific Value of Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Serum Levels on Survival and Recurrence in Pancreatic Cancer: A Single Center Study and Meta-Analysis |
| title_short | Stage-Specific Value of Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Serum Levels on Survival and Recurrence in Pancreatic Cancer: A Single Center Study and Meta-Analysis |
| title_sort | stage specific value of carbohydrate antigen 19 9 and carcinoembryonic antigen serum levels on survival and recurrence in pancreatic cancer a single center study and meta analysis |
| topic | pancreatic neoplasms carcinoembryonic antigen carbohydrate antigen 19.9 survival recurrence |
| url | https://www.mdpi.com/2072-6694/12/10/2970 |
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