Safety evaluation of a novel topical combination of esafoxolaner, eprinomectin and praziquantel, in reproducing female cats
NexGard® Combo, a novel topical endectoparasiticide product for cats, is a combination of esafoxolaner, eprinomectin and praziquantel. The safety of this novel combination administered to females during reproduction and lactation was evaluated per analysis of breeding parameters and adverse reaction...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2021-01-01
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| Series: | Parasite |
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| Online Access: | https://www.parasite-journal.org/articles/parasite/full_html/2021/01/parasite200188/parasite200188.html |
| _version_ | 1797642270762074112 |
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| author | Tielemans Eric Erasmus Heidi Momberg Mandie Pfefferkorn Anthony Targa Norba Chilakapati Jaya Gupta Aradhana |
| author_facet | Tielemans Eric Erasmus Heidi Momberg Mandie Pfefferkorn Anthony Targa Norba Chilakapati Jaya Gupta Aradhana |
| author_sort | Tielemans Eric |
| collection | DOAJ |
| description | NexGard® Combo, a novel topical endectoparasiticide product for cats, is a combination of esafoxolaner, eprinomectin and praziquantel. The safety of this novel combination administered to females during reproduction and lactation was evaluated per analysis of breeding parameters and adverse reactions observed on females and offspring. Females with successful breeding history were randomized to three groups, a placebo group and groups treated with the novel formulation at 1× or 3× multiples of the maximum exposure dose. Females were dosed at 28-day intervals, at least twice before mating, then during a period including mating, pregnancy, whelping and 56 days of lactation. In the placebo, 1× and 3× groups, 10, 9 and 10 females, respectively completed the study (nine, seven and nine females achieved pregnancy), and were dosed 7.1 times on average. Breeding parameters included success of mating, success of gestation, length of gestation, abortion rate, number of live, dead and stillborn kittens at birth, number of kittens with abnormalities, weight of kittens after birth and at weaning, growth of kittens, proportion of male and female kittens, and proportion of kittens born alive and weaned. No significant adverse reactions related to the novel combination were observed on females and on kittens; no significant and adverse effects on breeding parameters were observed. |
| first_indexed | 2024-03-11T13:57:43Z |
| format | Article |
| id | doaj.art-f9192779e7514f88b6b3cb0d8895f228 |
| institution | Directory Open Access Journal |
| issn | 1776-1042 |
| language | English |
| last_indexed | 2024-03-11T13:57:43Z |
| publishDate | 2021-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-f9192779e7514f88b6b3cb0d8895f2282023-11-02T06:31:55ZengEDP SciencesParasite1776-10422021-01-01282010.1051/parasite/2021016parasite200188Safety evaluation of a novel topical combination of esafoxolaner, eprinomectin and praziquantel, in reproducing female catsTielemans Eric0https://orcid.org/0000-0003-4798-3246Erasmus Heidi1Momberg Mandie2Pfefferkorn Anthony3Targa Norba4Chilakapati Jaya5Gupta Aradhana6Boehringer Ingelheim Animal HealthClinvet International (Pty) Ltd.Clinvet International (Pty) Ltd.Boehringer Ingelheim Animal HealthBoehringer Ingelheim Animal HealthBoehringer Ingelheim Animal HealthBoehringer Ingelheim Animal HealthNexGard® Combo, a novel topical endectoparasiticide product for cats, is a combination of esafoxolaner, eprinomectin and praziquantel. The safety of this novel combination administered to females during reproduction and lactation was evaluated per analysis of breeding parameters and adverse reactions observed on females and offspring. Females with successful breeding history were randomized to three groups, a placebo group and groups treated with the novel formulation at 1× or 3× multiples of the maximum exposure dose. Females were dosed at 28-day intervals, at least twice before mating, then during a period including mating, pregnancy, whelping and 56 days of lactation. In the placebo, 1× and 3× groups, 10, 9 and 10 females, respectively completed the study (nine, seven and nine females achieved pregnancy), and were dosed 7.1 times on average. Breeding parameters included success of mating, success of gestation, length of gestation, abortion rate, number of live, dead and stillborn kittens at birth, number of kittens with abnormalities, weight of kittens after birth and at weaning, growth of kittens, proportion of male and female kittens, and proportion of kittens born alive and weaned. No significant adverse reactions related to the novel combination were observed on females and on kittens; no significant and adverse effects on breeding parameters were observed.https://www.parasite-journal.org/articles/parasite/full_html/2021/01/parasite200188/parasite200188.htmlcatreproductionesafoxolanereprinomectinpraziquantelsafety |
| spellingShingle | Tielemans Eric Erasmus Heidi Momberg Mandie Pfefferkorn Anthony Targa Norba Chilakapati Jaya Gupta Aradhana Safety evaluation of a novel topical combination of esafoxolaner, eprinomectin and praziquantel, in reproducing female cats Parasite cat reproduction esafoxolaner eprinomectin praziquantel safety |
| title | Safety evaluation of a novel topical combination of esafoxolaner, eprinomectin and praziquantel, in reproducing female cats |
| title_full | Safety evaluation of a novel topical combination of esafoxolaner, eprinomectin and praziquantel, in reproducing female cats |
| title_fullStr | Safety evaluation of a novel topical combination of esafoxolaner, eprinomectin and praziquantel, in reproducing female cats |
| title_full_unstemmed | Safety evaluation of a novel topical combination of esafoxolaner, eprinomectin and praziquantel, in reproducing female cats |
| title_short | Safety evaluation of a novel topical combination of esafoxolaner, eprinomectin and praziquantel, in reproducing female cats |
| title_sort | safety evaluation of a novel topical combination of esafoxolaner eprinomectin and praziquantel in reproducing female cats |
| topic | cat reproduction esafoxolaner eprinomectin praziquantel safety |
| url | https://www.parasite-journal.org/articles/parasite/full_html/2021/01/parasite200188/parasite200188.html |
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