Stromal ColXα1 expression correlates with tumor-infiltrating lymphocytes and predicts adjuvant therapy outcome in ER-positive/HER2-positive breast cancer

Stromal ColXα1 expression correlates with tumor-infiltrating lymphocytes and predicts adjuvant therapy outcome in ER-positive/HER2-positive breast cancer

Abstract Background The breast cancer microenvironment contributes to tumor progression and response to chemotherapy. Previously, we reported that increased stromal Type X collagen α1 (ColXα1) and low TILs correlated with poor pathologic response to neoadjuvant therapy in estrogen receptor and HER2-...

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Bibliographic Details
Main Authors: Chaohui Lisa Zhao, Kamaljeet Singh, Alexander S. Brodsky, Shaolei Lu, Theresa A. Graves, Mary Anne Fenton, Dongfang Yang, Ashlee Sturtevant, Murray B. Resnick, Yihong Wang
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Cancer
Subjects:
Collagen
Tumor infiltrating lymphocytes
Tumor microenvironment
Breast cancer
Adjuvant chemotherapy
Online Access:http://link.springer.com/article/10.1186/s12885-019-6134-y

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