Recent advances in screening active components from natural products based on bioaffinity techniques
Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (20...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221138352030592X |
| _version_ | 1818117023487492096 |
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| author | Xiaofang Hou Meng Sun Tao Bao Xiaoyu Xie Fen Wei Sicen Wang |
| author_facet | Xiaofang Hou Meng Sun Tao Bao Xiaoyu Xie Fen Wei Sicen Wang |
| author_sort | Xiaofang Hou |
| collection | DOAJ |
| description | Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques, including biological chromatography, affinity electrophoresis, affinity mass spectroscopy, and the latest magnetic and optical methods. These screening methods are uniquely advanced compared to other traditional methods, and they can fish out the active components from complex natural products because of the affinity between target and components, without tedious separation works. Therefore, these new tools can reduce the time and cost of the drug discovery process and accelerate the development of more effective and better-targeted therapeutic agents. |
| first_indexed | 2024-12-11T04:31:49Z |
| format | Article |
| id | doaj.art-f91c46592cb54579bf7e77477ff9530d |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-12-11T04:31:49Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-f91c46592cb54579bf7e77477ff9530d2022-12-22T01:20:51ZengElsevierActa Pharmaceutica Sinica B2211-38352020-10-01101018001813Recent advances in screening active components from natural products based on bioaffinity techniquesXiaofang Hou0Meng Sun1Tao Bao2Xiaoyu Xie3Fen Wei4Sicen Wang5School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China; Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, ChinaCollege of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an 712046, China; Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, ChinaSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China; Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, ChinaSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China; Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, ChinaSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China; Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, ChinaSchool of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China; Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, China; Corresponding author. Tel.: +86 29 82656788; fax: +86 29 82655451.Natural products have provided numerous lead compounds for drug discovery. However, the traditional analytical methods cannot detect most of these active components, especially at their usual low concentrations, from complex natural products. Herein, we reviewed the recent technological advances (2015–2019) related to the separation and screening bioactive components from natural resources, especially the emerging screening methods based on the bioaffinity techniques, including biological chromatography, affinity electrophoresis, affinity mass spectroscopy, and the latest magnetic and optical methods. These screening methods are uniquely advanced compared to other traditional methods, and they can fish out the active components from complex natural products because of the affinity between target and components, without tedious separation works. Therefore, these new tools can reduce the time and cost of the drug discovery process and accelerate the development of more effective and better-targeted therapeutic agents.http://www.sciencedirect.com/science/article/pii/S221138352030592XScreeningActive componentsNatural productsBioaffinity techniques |
| spellingShingle | Xiaofang Hou Meng Sun Tao Bao Xiaoyu Xie Fen Wei Sicen Wang Recent advances in screening active components from natural products based on bioaffinity techniques Acta Pharmaceutica Sinica B Screening Active components Natural products Bioaffinity techniques |
| title | Recent advances in screening active components from natural products based on bioaffinity techniques |
| title_full | Recent advances in screening active components from natural products based on bioaffinity techniques |
| title_fullStr | Recent advances in screening active components from natural products based on bioaffinity techniques |
| title_full_unstemmed | Recent advances in screening active components from natural products based on bioaffinity techniques |
| title_short | Recent advances in screening active components from natural products based on bioaffinity techniques |
| title_sort | recent advances in screening active components from natural products based on bioaffinity techniques |
| topic | Screening Active components Natural products Bioaffinity techniques |
| url | http://www.sciencedirect.com/science/article/pii/S221138352030592X |
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