Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry
Abstract Off-target interactions between antisense oligonucleotides (ASOs) with state-of-the-art modifications and biological components still pose clinical safety liabilities. To mitigate a broad spectrum of off-target interactions and enhance the safety profile of ASO drugs, we here devise a nanoa...
| Main Authors: | , , , , , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
Nature Portfolio
2023-12-01
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| 叢編: | Nature Communications |
| 在線閱讀: | https://doi.org/10.1038/s41467-023-43714-0 |