Central presynaptic terminals are enriched in ATP but the majority lack mitochondria.

Central presynaptic terminals are enriched in ATP but the majority lack mitochondria.

Synaptic neurotransmission is known to be an energy demanding process. At the presynapse, ATP is required for loading neurotransmitters into synaptic vesicles, for priming synaptic vesicles before release, and as a substrate for various kinases and ATPases. Although it is assumed that presynaptic si...

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Bibliographic Details
Main Authors: Vrushali Chavan, Jeffery Willis, Sidney K Walker, Helen R Clark, Xinran Liu, Michael A Fox, Sarika Srivastava, Konark Mukherjee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4416033?pdf=render

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