The effect of <it>H. pylori </it>eradication on meal-associated changes in plasma ghrelin and leptin
<p>Abstract</p> <p>Background</p> <p>Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by <it>H. pylori </it>colonization. We prospectively evaluated the effect of <it>H. p...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-04-01
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| Series: | BMC Gastroenterology |
| Online Access: | http://www.biomedcentral.com/1471-230X/11/37 |
| _version_ | 1818391730201821184 |
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| author | Chhada Aditi Pei Zhiheng Joseph Neal Roper Jatin Francois Fritz Shak Joshua R de Perez Asalia Perez-Perez Guillermo I Blaser Martin J |
| author_facet | Chhada Aditi Pei Zhiheng Joseph Neal Roper Jatin Francois Fritz Shak Joshua R de Perez Asalia Perez-Perez Guillermo I Blaser Martin J |
| author_sort | Chhada Aditi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by <it>H. pylori </it>colonization. We prospectively evaluated the effect of <it>H. pylori </it>eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight.</p> <p>Methods</p> <p>Veterans referred for upper GI endoscopy were evaluated at baseline and ≥8 weeks after endoscopy, and <it>H. pylori </it>status and body weight were ascertained. During the first visit in all subjects, and during subsequent visits in the initially <it>H. pylori</it>-positive subjects and controls, blood was collected after an overnight fast and 1 h after a standard high protein meal, and levels of eight hormones determined.</p> <p>Results</p> <p>Of 92 enrolled subjects, 38 were <it>H. pylori</it>-negative, 44 <it>H. pylori</it>-positive, and 10 were indeterminate. Among 23 <it>H. pylori</it>-positive subjects who completed evaluation after treatment, 21 were eradicated, and 2 failed eradication. After a median of seven months following eradication, six hormones related to energy homeostasis showed no significant differences, but post-prandial acylated ghrelin levels were nearly six-fold higher than pre-eradication (p = 0.005), and median integrated leptin levels also increased (20%) significantly (p < 0.001). BMI significantly increased (5 ± 2%; p = 0.008) over 18 months in the initially <it>H. pylori</it>-positive individuals, but was not significantly changed in those who were <it>H. pylori</it>-negative or indeterminant at baseline.</p> <p>Conclusions</p> <p>Circulating meal-associated leptin and ghrelin levels and BMI changed significantly after <it>H. pylori </it>eradication, providing direct evidence that <it>H. pylori </it>colonization is involved in ghrelin and leptin regulation, with consequent effects on body morphometry.</p> |
| first_indexed | 2024-12-14T05:18:10Z |
| format | Article |
| id | doaj.art-f91deee1ce194406881b6ae589f393ad |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-14T05:18:10Z |
| publishDate | 2011-04-01 |
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| series | BMC Gastroenterology |
| spelling | doaj.art-f91deee1ce194406881b6ae589f393ad2022-12-21T23:15:46ZengBMCBMC Gastroenterology1471-230X2011-04-011113710.1186/1471-230X-11-37The effect of <it>H. pylori </it>eradication on meal-associated changes in plasma ghrelin and leptinChhada AditiPei ZhihengJoseph NealRoper JatinFrancois FritzShak Joshua Rde Perez AsaliaPerez-Perez Guillermo IBlaser Martin J<p>Abstract</p> <p>Background</p> <p>Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by <it>H. pylori </it>colonization. We prospectively evaluated the effect of <it>H. pylori </it>eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight.</p> <p>Methods</p> <p>Veterans referred for upper GI endoscopy were evaluated at baseline and ≥8 weeks after endoscopy, and <it>H. pylori </it>status and body weight were ascertained. During the first visit in all subjects, and during subsequent visits in the initially <it>H. pylori</it>-positive subjects and controls, blood was collected after an overnight fast and 1 h after a standard high protein meal, and levels of eight hormones determined.</p> <p>Results</p> <p>Of 92 enrolled subjects, 38 were <it>H. pylori</it>-negative, 44 <it>H. pylori</it>-positive, and 10 were indeterminate. Among 23 <it>H. pylori</it>-positive subjects who completed evaluation after treatment, 21 were eradicated, and 2 failed eradication. After a median of seven months following eradication, six hormones related to energy homeostasis showed no significant differences, but post-prandial acylated ghrelin levels were nearly six-fold higher than pre-eradication (p = 0.005), and median integrated leptin levels also increased (20%) significantly (p < 0.001). BMI significantly increased (5 ± 2%; p = 0.008) over 18 months in the initially <it>H. pylori</it>-positive individuals, but was not significantly changed in those who were <it>H. pylori</it>-negative or indeterminant at baseline.</p> <p>Conclusions</p> <p>Circulating meal-associated leptin and ghrelin levels and BMI changed significantly after <it>H. pylori </it>eradication, providing direct evidence that <it>H. pylori </it>colonization is involved in ghrelin and leptin regulation, with consequent effects on body morphometry.</p>http://www.biomedcentral.com/1471-230X/11/37 |
| spellingShingle | Chhada Aditi Pei Zhiheng Joseph Neal Roper Jatin Francois Fritz Shak Joshua R de Perez Asalia Perez-Perez Guillermo I Blaser Martin J The effect of <it>H. pylori </it>eradication on meal-associated changes in plasma ghrelin and leptin BMC Gastroenterology |
| title | The effect of <it>H. pylori </it>eradication on meal-associated changes in plasma ghrelin and leptin |
| title_full | The effect of <it>H. pylori </it>eradication on meal-associated changes in plasma ghrelin and leptin |
| title_fullStr | The effect of <it>H. pylori </it>eradication on meal-associated changes in plasma ghrelin and leptin |
| title_full_unstemmed | The effect of <it>H. pylori </it>eradication on meal-associated changes in plasma ghrelin and leptin |
| title_short | The effect of <it>H. pylori </it>eradication on meal-associated changes in plasma ghrelin and leptin |
| title_sort | effect of it h pylori it eradication on meal associated changes in plasma ghrelin and leptin |
| url | http://www.biomedcentral.com/1471-230X/11/37 |
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