Understanding the clinical spectrum of complicated <it>Plasmodium vivax </it>malaria: a systematic review on the contributions of the Brazilian literature
<p>Abstract</p> <p>The resurgence of the malaria eradication agenda and the increasing number of severe manifestation reports has contributed to a renewed interested in the <it>Plasmodium vivax </it>infection. It is the most geographically widespread parasite causing hu...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-01-01
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| Series: | Malaria Journal |
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| Online Access: | http://www.malariajournal.com/content/11/1/12 |
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| author | Lacerda Marcus VG Mourão Maria PG Alexandre Márcia AA Siqueira André M Magalhães Belisa ML Martinez-Espinosa Flor E Santana Filho Franklin S Brasil Patrícia Ventura Ana MRS Tada Mauro S Couto Vanja SCD Silva Antônio R Silva Rita SU Alecrim Maria GC |
| author_facet | Lacerda Marcus VG Mourão Maria PG Alexandre Márcia AA Siqueira André M Magalhães Belisa ML Martinez-Espinosa Flor E Santana Filho Franklin S Brasil Patrícia Ventura Ana MRS Tada Mauro S Couto Vanja SCD Silva Antônio R Silva Rita SU Alecrim Maria GC |
| author_sort | Lacerda Marcus VG |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The resurgence of the malaria eradication agenda and the increasing number of severe manifestation reports has contributed to a renewed interested in the <it>Plasmodium vivax </it>infection. It is the most geographically widespread parasite causing human malaria, with around 2.85 billion people living under risk of infection. The Brazilian Amazon region reports more than 50% of the malaria cases in Latin America and since 1990 there is a marked predominance of this species, responsible for 85% of cases in 2009. However, only a few complicated cases of <it>P. vivax </it>have been reported from this region. A systematic review of the Brazilian indexed and non-indexed literature on complicated cases of vivax malaria was performed including published articles, masters' dissertations, doctoral theses and national congresses' abstracts. The following information was retrieved: patient characteristics (demographic, presence of co-morbidities and, whenever possible, associated genetic disorders); description of each major clinical manifestation. As a result, 27 articles, 28 abstracts from scientific events' annals and 13 theses/dissertations were found, only after 1987. Most of the reported information was described in small case series and case reports of patients from all the Amazonian states, and also in travellers from Brazilian non-endemic areas. The more relevant clinical complications were anaemia, thrombocytopaenia, jaundice and acute respiratory distress syndrome, present in all age groups, in addition to other more rare clinical pictures. Complications in pregnant women were also reported. Acute and chronic co-morbidities were frequent, however death was occasional. Clinical atypical cases of malaria are more frequent than published in the indexed literature, probably due to a publication bias. In the Brazilian Amazon (considered to be a low to moderate intensity area of transmission), clinical data are in accordance with the recent findings of severity described in diverse <it>P. vivax </it>endemic areas (especially anaemia in Southeast Asia), however in this region both children and adults are affected. Finally, gaps of knowledge and areas for future research are opportunely pointed out.</p> |
| first_indexed | 2024-12-11T00:00:39Z |
| format | Article |
| id | doaj.art-f91e5e17065b407d953797f456727936 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-11T00:00:39Z |
| publishDate | 2012-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-f91e5e17065b407d953797f4567279362022-12-22T01:28:28ZengBMCMalaria Journal1475-28752012-01-011111210.1186/1475-2875-11-12Understanding the clinical spectrum of complicated <it>Plasmodium vivax </it>malaria: a systematic review on the contributions of the Brazilian literatureLacerda Marcus VGMourão Maria PGAlexandre Márcia AASiqueira André MMagalhães Belisa MLMartinez-Espinosa Flor ESantana Filho Franklin SBrasil PatríciaVentura Ana MRSTada Mauro SCouto Vanja SCDSilva Antônio RSilva Rita SUAlecrim Maria GC<p>Abstract</p> <p>The resurgence of the malaria eradication agenda and the increasing number of severe manifestation reports has contributed to a renewed interested in the <it>Plasmodium vivax </it>infection. It is the most geographically widespread parasite causing human malaria, with around 2.85 billion people living under risk of infection. The Brazilian Amazon region reports more than 50% of the malaria cases in Latin America and since 1990 there is a marked predominance of this species, responsible for 85% of cases in 2009. However, only a few complicated cases of <it>P. vivax </it>have been reported from this region. A systematic review of the Brazilian indexed and non-indexed literature on complicated cases of vivax malaria was performed including published articles, masters' dissertations, doctoral theses and national congresses' abstracts. The following information was retrieved: patient characteristics (demographic, presence of co-morbidities and, whenever possible, associated genetic disorders); description of each major clinical manifestation. As a result, 27 articles, 28 abstracts from scientific events' annals and 13 theses/dissertations were found, only after 1987. Most of the reported information was described in small case series and case reports of patients from all the Amazonian states, and also in travellers from Brazilian non-endemic areas. The more relevant clinical complications were anaemia, thrombocytopaenia, jaundice and acute respiratory distress syndrome, present in all age groups, in addition to other more rare clinical pictures. Complications in pregnant women were also reported. Acute and chronic co-morbidities were frequent, however death was occasional. Clinical atypical cases of malaria are more frequent than published in the indexed literature, probably due to a publication bias. In the Brazilian Amazon (considered to be a low to moderate intensity area of transmission), clinical data are in accordance with the recent findings of severity described in diverse <it>P. vivax </it>endemic areas (especially anaemia in Southeast Asia), however in this region both children and adults are affected. Finally, gaps of knowledge and areas for future research are opportunely pointed out.</p>http://www.malariajournal.com/content/11/1/12Malaria<it>Plasmodium vivax</it>BrazilSeverityClinical aspectsAnaemiaSystematic review |
| spellingShingle | Lacerda Marcus VG Mourão Maria PG Alexandre Márcia AA Siqueira André M Magalhães Belisa ML Martinez-Espinosa Flor E Santana Filho Franklin S Brasil Patrícia Ventura Ana MRS Tada Mauro S Couto Vanja SCD Silva Antônio R Silva Rita SU Alecrim Maria GC Understanding the clinical spectrum of complicated <it>Plasmodium vivax </it>malaria: a systematic review on the contributions of the Brazilian literature Malaria Journal Malaria <it>Plasmodium vivax</it> Brazil Severity Clinical aspects Anaemia Systematic review |
| title | Understanding the clinical spectrum of complicated <it>Plasmodium vivax </it>malaria: a systematic review on the contributions of the Brazilian literature |
| title_full | Understanding the clinical spectrum of complicated <it>Plasmodium vivax </it>malaria: a systematic review on the contributions of the Brazilian literature |
| title_fullStr | Understanding the clinical spectrum of complicated <it>Plasmodium vivax </it>malaria: a systematic review on the contributions of the Brazilian literature |
| title_full_unstemmed | Understanding the clinical spectrum of complicated <it>Plasmodium vivax </it>malaria: a systematic review on the contributions of the Brazilian literature |
| title_short | Understanding the clinical spectrum of complicated <it>Plasmodium vivax </it>malaria: a systematic review on the contributions of the Brazilian literature |
| title_sort | understanding the clinical spectrum of complicated it plasmodium vivax it malaria a systematic review on the contributions of the brazilian literature |
| topic | Malaria <it>Plasmodium vivax</it> Brazil Severity Clinical aspects Anaemia Systematic review |
| url | http://www.malariajournal.com/content/11/1/12 |
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