Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review
Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlyi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/18/10037 |
| _version_ | 1797518934982787072 |
|---|---|
| author | Izabela Koss-Mikołajczyk Vanja Todorovic Sladjana Sobajic Jamal Mahajna Marko Gerić Josep A. Tur Agnieszka Bartoszek |
| author_facet | Izabela Koss-Mikołajczyk Vanja Todorovic Sladjana Sobajic Jamal Mahajna Marko Gerić Josep A. Tur Agnieszka Bartoszek |
| author_sort | Izabela Koss-Mikołajczyk |
| collection | DOAJ |
| description | Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent. |
| first_indexed | 2024-03-10T07:35:21Z |
| format | Article |
| id | doaj.art-f91f2e130586452c9c12039708737380 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:35:21Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f91f2e130586452c9c120397087373802023-11-22T13:31:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122181003710.3390/ijms221810037Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive ReviewIzabela Koss-Mikołajczyk0Vanja Todorovic1Sladjana Sobajic2Jamal Mahajna3Marko Gerić4Josep A. Tur5Agnieszka Bartoszek6Department of Food Chemistry, Technology and Biotechnology, Gdańsk University of Technology, 11/12 Narutowicza St., 80-233 Gdańsk, PolandDepartment of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Nutrition and Natural Products, Migal-Galilee Research Institute, Kiryat Shmona 11016, IsraelMutagenesis Unit, Institute for Medical Research and Occupational Health, 10000 Zagreb, CroatiaResearch Group on Community Nutrition & Oxidative Stress, University of Balearic Islands—IUNICS, IDISBA & CIBEROBN (Physiopathology of Obesity and Nutrition), 07122 Palma de Mallorca, SpainDepartment of Food Chemistry, Technology and Biotechnology, Gdańsk University of Technology, 11/12 Narutowicza St., 80-233 Gdańsk, PolandCardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent.https://www.mdpi.com/1422-0067/22/18/10037cardiotoxicitycardioprotectantsphytochemicalsantioxidantsanthracyclines |
| spellingShingle | Izabela Koss-Mikołajczyk Vanja Todorovic Sladjana Sobajic Jamal Mahajna Marko Gerić Josep A. Tur Agnieszka Bartoszek Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review International Journal of Molecular Sciences cardiotoxicity cardioprotectants phytochemicals antioxidants anthracyclines |
| title | Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review |
| title_full | Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review |
| title_fullStr | Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review |
| title_full_unstemmed | Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review |
| title_short | Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review |
| title_sort | natural products counteracting cardiotoxicity during cancer chemotherapy the special case of doxorubicin a comprehensive review |
| topic | cardiotoxicity cardioprotectants phytochemicals antioxidants anthracyclines |
| url | https://www.mdpi.com/1422-0067/22/18/10037 |
| work_keys_str_mv | AT izabelakossmikołajczyk naturalproductscounteractingcardiotoxicityduringcancerchemotherapythespecialcaseofdoxorubicinacomprehensivereview AT vanjatodorovic naturalproductscounteractingcardiotoxicityduringcancerchemotherapythespecialcaseofdoxorubicinacomprehensivereview AT sladjanasobajic naturalproductscounteractingcardiotoxicityduringcancerchemotherapythespecialcaseofdoxorubicinacomprehensivereview AT jamalmahajna naturalproductscounteractingcardiotoxicityduringcancerchemotherapythespecialcaseofdoxorubicinacomprehensivereview AT markogeric naturalproductscounteractingcardiotoxicityduringcancerchemotherapythespecialcaseofdoxorubicinacomprehensivereview AT josepatur naturalproductscounteractingcardiotoxicityduringcancerchemotherapythespecialcaseofdoxorubicinacomprehensivereview AT agnieszkabartoszek naturalproductscounteractingcardiotoxicityduringcancerchemotherapythespecialcaseofdoxorubicinacomprehensivereview |