Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling
Bone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy functioning. To maintain normal cellular and phys...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/6/3233 |
| _version_ | 1797470863351611392 |
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| author | Ricardo Usategui-Martín Ricardo Rigual Marta Ruiz-Mambrilla José-María Fernández-Gómez Antonio Dueñas José Luis Pérez-Castrillón |
| author_facet | Ricardo Usategui-Martín Ricardo Rigual Marta Ruiz-Mambrilla José-María Fernández-Gómez Antonio Dueñas José Luis Pérez-Castrillón |
| author_sort | Ricardo Usategui-Martín |
| collection | DOAJ |
| description | Bone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy functioning. To maintain normal cellular and physiological bone functions sufficient oxygen is required, as evidence has shown that hypoxia may influence bone health. In this scenario, this review aimed to analyze the molecular mechanisms involved in hypoxia-induced bone remodeling alterations and their possible clinical consequences. Hypoxia has been associated with reduced bone formation and reduced osteoblast matrix mineralization due to the hypoxia environment inhibiting osteoblast differentiation. A hypoxic environment is involved with increased osteoclastogenesis and increased bone resorptive capacity of the osteoclasts. Clinical studies, although with contradictory results, have shown that hypoxia can modify bone remodeling. |
| first_indexed | 2024-03-09T19:42:57Z |
| format | Article |
| id | doaj.art-f91f39f5f4874310907ab7509ad39d6a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:42:57Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f91f39f5f4874310907ab7509ad39d6a2023-11-24T01:35:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01236323310.3390/ijms23063233Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone RemodelingRicardo Usategui-Martín0Ricardo Rigual1Marta Ruiz-Mambrilla2José-María Fernández-Gómez3Antonio Dueñas4José Luis Pérez-Castrillón5Department of Cell Biology, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47003 Valladolid, SpainDepartment of Biochemistry, Molecular Biology and Physiology, Faculty of Medicine, University of Valladolid, 47003 Valladolid, SpainDepartment of Surgery, Faculty of Medicine, University of Valladolid, 47003 Valladolid, SpainDepartment of Cell Biology, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47003 Valladolid, SpainDepartment of Medicine, Faculty of Medicine, University of Valladolid, 47003 Valladolid, SpainDepartment of Medicine, Faculty of Medicine, University of Valladolid, 47003 Valladolid, SpainBone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy functioning. To maintain normal cellular and physiological bone functions sufficient oxygen is required, as evidence has shown that hypoxia may influence bone health. In this scenario, this review aimed to analyze the molecular mechanisms involved in hypoxia-induced bone remodeling alterations and their possible clinical consequences. Hypoxia has been associated with reduced bone formation and reduced osteoblast matrix mineralization due to the hypoxia environment inhibiting osteoblast differentiation. A hypoxic environment is involved with increased osteoclastogenesis and increased bone resorptive capacity of the osteoclasts. Clinical studies, although with contradictory results, have shown that hypoxia can modify bone remodeling.https://www.mdpi.com/1422-0067/23/6/3233hypoxiabone remodelingHIFosteoclastosteoblastoxygen |
| spellingShingle | Ricardo Usategui-Martín Ricardo Rigual Marta Ruiz-Mambrilla José-María Fernández-Gómez Antonio Dueñas José Luis Pérez-Castrillón Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling International Journal of Molecular Sciences hypoxia bone remodeling HIF osteoclast osteoblast oxygen |
| title | Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling |
| title_full | Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling |
| title_fullStr | Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling |
| title_full_unstemmed | Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling |
| title_short | Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling |
| title_sort | molecular mechanisms involved in hypoxia induced alterations in bone remodeling |
| topic | hypoxia bone remodeling HIF osteoclast osteoblast oxygen |
| url | https://www.mdpi.com/1422-0067/23/6/3233 |
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