Intraoperative Assessment of Fluid Responsiveness in Normotensive Dogs under Isoflurane Anaesthesia
The aim of this study was to evaluate the incidence of fluid responsiveness (FR) to a fluid challenge (FC) in normotensive dogs under anaesthesia. The accuracy of pulse pressure variation (PPV), systolic pressure variation (SPV), stroke volume variation (SVV), and plethysmographic variability index...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/8/2/26 |
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| author | Despoina Skouropoulou Luca Lacitignola Caterina Di Bella Marzia Stabile Claudia Acquafredda Nicola Brienza Salvatore Grasso Antonio Crovace Fabrizio Iarussi Francesco Staffieri |
| author_facet | Despoina Skouropoulou Luca Lacitignola Caterina Di Bella Marzia Stabile Claudia Acquafredda Nicola Brienza Salvatore Grasso Antonio Crovace Fabrizio Iarussi Francesco Staffieri |
| author_sort | Despoina Skouropoulou |
| collection | DOAJ |
| description | The aim of this study was to evaluate the incidence of fluid responsiveness (FR) to a fluid challenge (FC) in normotensive dogs under anaesthesia. The accuracy of pulse pressure variation (PPV), systolic pressure variation (SPV), stroke volume variation (SVV), and plethysmographic variability index (PVI) for predicting FR was also evaluated. Dogs were anaesthetised with methadone, propofol, and inhaled isoflurane in oxygen, under volume-controlled mechanical ventilation. FC was performed by the administration of 5 mL/kg of Ringer’s lactate within 5 min. Cardiac index (CI; L/min/m<sup>2</sup>), PPV, (%), SVV (%), SPV (%), and PVI (%) were registered before and after FC. Data were analysed with ANOVA and ROC tests (<i>p</i> < 0.05). Fluid responsiveness was defined as 15% increase in CI. Eighty dogs completed the study. Fifty (62.5%) were responders and 30 (37.5%) were nonresponders. The PPV, PVI, SPV, and SVV cut-off values (AUC, <i>p</i>) for discriminating responders from nonresponders were PPV >13.8% (0.979, <0.001), PVI >14% (0.956, <0.001), SPV >4.1% (0.793, <0.001), and SVV >14.7% (0.729, <0.001), respectively. Up to 62.5% of normotensive dogs under inhalant anaesthesia may be fluid responders. PPV and PVI have better diagnostic accuracy to predict FR, compared to SPV and SVV. |
| first_indexed | 2024-03-09T04:44:30Z |
| format | Article |
| id | doaj.art-f91f6e9240c64c5aa389679e6102b615 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T04:44:30Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-f91f6e9240c64c5aa389679e6102b6152023-12-03T13:18:16ZengMDPI AGVeterinary Sciences2306-73812021-02-01822610.3390/vetsci8020026Intraoperative Assessment of Fluid Responsiveness in Normotensive Dogs under Isoflurane AnaesthesiaDespoina Skouropoulou0Luca Lacitignola1Caterina Di Bella2Marzia Stabile3Claudia Acquafredda4Nicola Brienza5Salvatore Grasso6Antonio Crovace7Fabrizio Iarussi8Francesco Staffieri9Section of Veterinary Clinics and Animal Production, Department of Emergency and Organ Transplantation, Aldo Moro University, 70010 Bari, ItalySection of Veterinary Clinics and Animal Production, Department of Emergency and Organ Transplantation, Aldo Moro University, 70010 Bari, ItalySection of Veterinary Clinics and Animal Production, Department of Emergency and Organ Transplantation, Aldo Moro University, 70010 Bari, ItalySection of Veterinary Clinics and Animal Production, Department of Emergency and Organ Transplantation, Aldo Moro University, 70010 Bari, ItalySection of Veterinary Clinics and Animal Production, Department of Emergency and Organ Transplantation, Aldo Moro University, 70010 Bari, ItalySection of Anesthesia and Intensive Care, Department of Emergency and Organ Transplantation, Aldo Moro University, 70124 Bari, ItalySection of Anesthesia and Intensive Care, Department of Emergency and Organ Transplantation, Aldo Moro University, 70124 Bari, ItalySection of Veterinary Clinics and Animal Production, Department of Emergency and Organ Transplantation, Aldo Moro University, 70010 Bari, ItalySection of Veterinary Clinics and Animal Production, Department of Emergency and Organ Transplantation, Aldo Moro University, 70010 Bari, ItalySection of Veterinary Clinics and Animal Production, Department of Emergency and Organ Transplantation, Aldo Moro University, 70010 Bari, ItalyThe aim of this study was to evaluate the incidence of fluid responsiveness (FR) to a fluid challenge (FC) in normotensive dogs under anaesthesia. The accuracy of pulse pressure variation (PPV), systolic pressure variation (SPV), stroke volume variation (SVV), and plethysmographic variability index (PVI) for predicting FR was also evaluated. Dogs were anaesthetised with methadone, propofol, and inhaled isoflurane in oxygen, under volume-controlled mechanical ventilation. FC was performed by the administration of 5 mL/kg of Ringer’s lactate within 5 min. Cardiac index (CI; L/min/m<sup>2</sup>), PPV, (%), SVV (%), SPV (%), and PVI (%) were registered before and after FC. Data were analysed with ANOVA and ROC tests (<i>p</i> < 0.05). Fluid responsiveness was defined as 15% increase in CI. Eighty dogs completed the study. Fifty (62.5%) were responders and 30 (37.5%) were nonresponders. The PPV, PVI, SPV, and SVV cut-off values (AUC, <i>p</i>) for discriminating responders from nonresponders were PPV >13.8% (0.979, <0.001), PVI >14% (0.956, <0.001), SPV >4.1% (0.793, <0.001), and SVV >14.7% (0.729, <0.001), respectively. Up to 62.5% of normotensive dogs under inhalant anaesthesia may be fluid responders. PPV and PVI have better diagnostic accuracy to predict FR, compared to SPV and SVV.https://www.mdpi.com/2306-7381/8/2/26dogsfluid responsivenesspulse pressure variationsystolic pressure variationstroke volume variationplethysmographic variability index |
| spellingShingle | Despoina Skouropoulou Luca Lacitignola Caterina Di Bella Marzia Stabile Claudia Acquafredda Nicola Brienza Salvatore Grasso Antonio Crovace Fabrizio Iarussi Francesco Staffieri Intraoperative Assessment of Fluid Responsiveness in Normotensive Dogs under Isoflurane Anaesthesia Veterinary Sciences dogs fluid responsiveness pulse pressure variation systolic pressure variation stroke volume variation plethysmographic variability index |
| title | Intraoperative Assessment of Fluid Responsiveness in Normotensive Dogs under Isoflurane Anaesthesia |
| title_full | Intraoperative Assessment of Fluid Responsiveness in Normotensive Dogs under Isoflurane Anaesthesia |
| title_fullStr | Intraoperative Assessment of Fluid Responsiveness in Normotensive Dogs under Isoflurane Anaesthesia |
| title_full_unstemmed | Intraoperative Assessment of Fluid Responsiveness in Normotensive Dogs under Isoflurane Anaesthesia |
| title_short | Intraoperative Assessment of Fluid Responsiveness in Normotensive Dogs under Isoflurane Anaesthesia |
| title_sort | intraoperative assessment of fluid responsiveness in normotensive dogs under isoflurane anaesthesia |
| topic | dogs fluid responsiveness pulse pressure variation systolic pressure variation stroke volume variation plethysmographic variability index |
| url | https://www.mdpi.com/2306-7381/8/2/26 |
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