Interventions to improve antiretroviral adherence in HIV-infected pregnant women: A systematic review and meta-analysis
BackgroundMedication adherence in HIV-infected pregnant women remains suboptimal. This systematic review and meta-analysis aimed to evaluate the effectiveness of interventions on improving antiretroviral adherence targeting among HIV-infected pregnant women.MethodsFive databases were screened to ide...
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1056915/full |
| _version_ | 1811177972457013248 |
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| author | Jie Zhou Jingyi Yun Xinxin Ye Wen Liu Wenhan Xiao Peige Song Hongmei Wang |
| author_facet | Jie Zhou Jingyi Yun Xinxin Ye Wen Liu Wenhan Xiao Peige Song Hongmei Wang |
| author_sort | Jie Zhou |
| collection | DOAJ |
| description | BackgroundMedication adherence in HIV-infected pregnant women remains suboptimal. This systematic review and meta-analysis aimed to evaluate the effectiveness of interventions on improving antiretroviral adherence targeting among HIV-infected pregnant women.MethodsFive databases were screened to identify quasi-experimental studies and randomized controlled trials. The risk ratios (RR) and confidential intervals (CI) were extracted to estimate the improvement in antiretroviral adherence after interventions compared with control conditions. This study was registered with PROSPERO, number CRD42021256317.ResultsNine studies were included in the review, totaling 2,900 participants. Three interventions had significance: enhanced standard of care (eSOC, RR 1.14, 95%CI 1.07–1.22, Z = 3.79, P < 0.01), eSOC with supporter (RR 1.12, 95%CI 1.04–1.20, Z = 2.97, P < 0.01) and device reminder (RR 1.33, 95%CI 1.04–1.72, Z = 2.23, P = 0.03).DiscussionThe study supported the eSOC and the device reminder as effective intervention strategies for improving HIV medication adherence. Based on the current findings, the study called for more efforts to improve antiretroviral care for pregnant women through involving multicenter, large-sample, and high-quality research and combining the device reminder with other intervention methods.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021256317, identifier CRD42021256317. |
| first_indexed | 2024-04-11T06:10:21Z |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T06:10:21Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-f920fd1fbb1e422cbffce6016e76bcc32022-12-22T04:41:17ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-12-011010.3389/fpubh.2022.10569151056915Interventions to improve antiretroviral adherence in HIV-infected pregnant women: A systematic review and meta-analysisJie Zhou0Jingyi Yun1Xinxin Ye2Wen Liu3Wenhan Xiao4Peige Song5Hongmei Wang6Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Social Medicine of School of Public Health and Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Social Medicine of School of Public Health and Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Social Medicine of School of Public Health and Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Social Medicine of School of Public Health and Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaBackgroundMedication adherence in HIV-infected pregnant women remains suboptimal. This systematic review and meta-analysis aimed to evaluate the effectiveness of interventions on improving antiretroviral adherence targeting among HIV-infected pregnant women.MethodsFive databases were screened to identify quasi-experimental studies and randomized controlled trials. The risk ratios (RR) and confidential intervals (CI) were extracted to estimate the improvement in antiretroviral adherence after interventions compared with control conditions. This study was registered with PROSPERO, number CRD42021256317.ResultsNine studies were included in the review, totaling 2,900 participants. Three interventions had significance: enhanced standard of care (eSOC, RR 1.14, 95%CI 1.07–1.22, Z = 3.79, P < 0.01), eSOC with supporter (RR 1.12, 95%CI 1.04–1.20, Z = 2.97, P < 0.01) and device reminder (RR 1.33, 95%CI 1.04–1.72, Z = 2.23, P = 0.03).DiscussionThe study supported the eSOC and the device reminder as effective intervention strategies for improving HIV medication adherence. Based on the current findings, the study called for more efforts to improve antiretroviral care for pregnant women through involving multicenter, large-sample, and high-quality research and combining the device reminder with other intervention methods.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021256317, identifier CRD42021256317.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1056915/fullHIVmedication adherenceantiretroviral therapypregnant womensystematic review |
| spellingShingle | Jie Zhou Jingyi Yun Xinxin Ye Wen Liu Wenhan Xiao Peige Song Hongmei Wang Interventions to improve antiretroviral adherence in HIV-infected pregnant women: A systematic review and meta-analysis Frontiers in Public Health HIV medication adherence antiretroviral therapy pregnant women systematic review |
| title | Interventions to improve antiretroviral adherence in HIV-infected pregnant women: A systematic review and meta-analysis |
| title_full | Interventions to improve antiretroviral adherence in HIV-infected pregnant women: A systematic review and meta-analysis |
| title_fullStr | Interventions to improve antiretroviral adherence in HIV-infected pregnant women: A systematic review and meta-analysis |
| title_full_unstemmed | Interventions to improve antiretroviral adherence in HIV-infected pregnant women: A systematic review and meta-analysis |
| title_short | Interventions to improve antiretroviral adherence in HIV-infected pregnant women: A systematic review and meta-analysis |
| title_sort | interventions to improve antiretroviral adherence in hiv infected pregnant women a systematic review and meta analysis |
| topic | HIV medication adherence antiretroviral therapy pregnant women systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1056915/full |
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