Intrinsic and extrinsic apoptosis responses in leukaemia cells following daunorubicin treatment

Intrinsic and extrinsic apoptosis responses in leukaemia cells following daunorubicin treatment

Abstract Background Daunorubicin is used clinically in the treatment of myeloma, acute lymphatic and myelocytic leukaemia. The toxic lesions caused by daunorubicin induce various modes of cell death, including apoptosis. Apoptosis is highly regulated programmed cell death that can be initiated mainl...

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Bibliographic Details
Main Authors: Hussain Mubarak Al-Aamri, Helen R. Irving, Christopher Bradley, Terri Meehan-Andrews
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Cancer
Subjects:
Daunorubicin
Apoptosis
Leukaemia
Mitochondrial membrane potential
Caspases
Online Access:https://doi.org/10.1186/s12885-021-08167-y

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