Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy

Abstract Objective Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Histone lysine-specific demethylase 1 (LSD1) is a flavin-containing amino oxidase that can repress or activate transcription. The aim of this study is to explore the mechanism of LSD1 aggravating DN-induced...

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Bibliographic Details
Main Authors: Lina Dong, Lei Yu, Jin Zhong
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Diabetology & Metabolic Syndrome
Subjects:
LSD1
Renal fibrosis
Diabetic nephropathy
TGF-β1/Smad3 pathway
SIRT3
Online Access:https://doi.org/10.1186/s13098-021-00771-z

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