“In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an array of hybrid E/M intermediates with mixed E and M features. Recent findings have demonstrated how these hybrid E/M rather th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1038841/full |
| _version_ | 1811189646538833920 |
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| author | Angelo Canciello Angelo Canciello Adrián Cerveró-Varona Alessia Peserico Annunziata Mauro Valentina Russo Andrea Morrione Antonio Giordano Antonio Giordano Antonio Giordano Barbara Barboni |
| author_facet | Angelo Canciello Angelo Canciello Adrián Cerveró-Varona Alessia Peserico Annunziata Mauro Valentina Russo Andrea Morrione Antonio Giordano Antonio Giordano Antonio Giordano Barbara Barboni |
| author_sort | Angelo Canciello |
| collection | DOAJ |
| description | Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an array of hybrid E/M intermediates with mixed E and M features. Recent findings have demonstrated how these hybrid E/M rather than fully M cells play key roles in most of physiological and pathological processes involving EMT. To this regard, the onset of hybrid E/M state coincides with the highest stemness gene expression and is involved in differentiation of either normal and cancer stem cells. Moreover, hybrid E/M cells are responsible for wound healing and create a favorable immunosuppressive environment for tissue regeneration. Nevertheless, hybrid state is responsible of metastatic process and of the increasing of survival, apoptosis and therapy resistance in cancer cells. The present review aims to describe the main features and the emerging concepts regulating EMP and the formation of E/M hybrid intermediates by describing differences and similarities between cancer and normal hybrid stem cells. In particular, the comprehension of hybrid E/M cells biology will surely advance our understanding of their features and how they could be exploited to improve tissue regeneration and repair. |
| first_indexed | 2024-04-11T14:38:00Z |
| format | Article |
| id | doaj.art-f925c719d24f48bbae0cf456894f5f2f |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T14:38:00Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-f925c719d24f48bbae0cf456894f5f2f2022-12-22T04:18:16ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-11-011010.3389/fcell.2022.10388411038841“In medio stat virtus”: Insights into hybrid E/M phenotype attitudesAngelo Canciello0Angelo Canciello1Adrián Cerveró-Varona2Alessia Peserico3Annunziata Mauro4Valentina Russo5Andrea Morrione6Antonio Giordano7Antonio Giordano8Antonio Giordano9Barbara Barboni10Faculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, ItalyDepartment of Biology, College of Science and Technology, Temple University, Philadelphia, PA, United StatesFaculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, ItalyFaculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, ItalyFaculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, ItalyFaculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, ItalyDepartment of Biology, College of Science and Technology, Temple University, Philadelphia, PA, United StatesDepartment of Biology, College of Science and Technology, Temple University, Philadelphia, PA, United StatesSbarro Health Research Organization (SHRO), Philadelphia, PA, United StatesDepartment of Medical Biotechnologies, University of Siena, Siena, ItalyFaculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, ItalyEpithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an array of hybrid E/M intermediates with mixed E and M features. Recent findings have demonstrated how these hybrid E/M rather than fully M cells play key roles in most of physiological and pathological processes involving EMT. To this regard, the onset of hybrid E/M state coincides with the highest stemness gene expression and is involved in differentiation of either normal and cancer stem cells. Moreover, hybrid E/M cells are responsible for wound healing and create a favorable immunosuppressive environment for tissue regeneration. Nevertheless, hybrid state is responsible of metastatic process and of the increasing of survival, apoptosis and therapy resistance in cancer cells. The present review aims to describe the main features and the emerging concepts regulating EMP and the formation of E/M hybrid intermediates by describing differences and similarities between cancer and normal hybrid stem cells. In particular, the comprehension of hybrid E/M cells biology will surely advance our understanding of their features and how they could be exploited to improve tissue regeneration and repair.https://www.frontiersin.org/articles/10.3389/fcell.2022.1038841/fullhybrid E/M phenotypepartial EMTstem cellcancerimmune evasionimmune suppression |
| spellingShingle | Angelo Canciello Angelo Canciello Adrián Cerveró-Varona Alessia Peserico Annunziata Mauro Valentina Russo Andrea Morrione Antonio Giordano Antonio Giordano Antonio Giordano Barbara Barboni “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes Frontiers in Cell and Developmental Biology hybrid E/M phenotype partial EMT stem cell cancer immune evasion immune suppression |
| title | “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes |
| title_full | “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes |
| title_fullStr | “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes |
| title_full_unstemmed | “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes |
| title_short | “In medio stat virtus”: Insights into hybrid E/M phenotype attitudes |
| title_sort | in medio stat virtus insights into hybrid e m phenotype attitudes |
| topic | hybrid E/M phenotype partial EMT stem cell cancer immune evasion immune suppression |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1038841/full |
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