Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed <i>ortho</i>-C(sp<sup>2</sup>)-H-Hydroxylation

Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed <i>ortho</i>-C(sp<sup>2</sup>)-H-Hydroxylation

The continuous, worldwide spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) endanger the World Health Organization’s (WHO) goal to end the global TB pandemic by the year 2035. During the past 50 years, very few new drugs have been approved by medical agencies...

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Bibliographic Details
Main Authors: Alexander Berger, Talea Knak, Anna-Lene Kiffe-Delf, Korana Mudrovcic, Vinayak Singh, Mathew Njoroge, Bjoern B. Burckhardt, Mohanraj Gopalswamy, Beate Lungerich, Lutz Ackermann, Holger Gohlke, Kelly Chibale, Rainer Kalscheuer, Thomas Kurz
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceuticals
Subjects:
<i>Mycobacterium tuberculosis</i>
natural product
flavonoid
acetohydroxyacid synthase inhibitor
<i>ortho</i>-C(sp<sup>2</sup>)-H-hydroxylation
4<i>H</i>-chromen-4-one
Online Access:https://www.mdpi.com/1424-8247/15/8/984

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