CNS remyelination and the innate immune system
A misguided inflammatory response is frequently implicated in myelin damage. Particularly prominent among myelin diseases, multiple sclerosis (MS) is an autoimmune condition, with immune–mediated damage central to its aetiology. Nevertheless, a robust inflammatory response is also essential for the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00038/full |
| _version_ | 1819102506670620672 |
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| author | Christopher E McMurran Clare A Jones Denise C Fitzgerald Robin J M Franklin |
| author_facet | Christopher E McMurran Clare A Jones Denise C Fitzgerald Robin J M Franklin |
| author_sort | Christopher E McMurran |
| collection | DOAJ |
| description | A misguided inflammatory response is frequently implicated in myelin damage. Particularly prominent among myelin diseases, multiple sclerosis (MS) is an autoimmune condition, with immune–mediated damage central to its aetiology. Nevertheless, a robust inflammatory response is also essential for the efficient regeneration of myelin sheaths after such injury. Here, we discuss the functions of inflammation that promote remyelination, and how these have been experimentally disentangled from the pathological facets of the immune response. We focus on the contributions that resident microglia and monocyte-derived macrophages make to remyelination and compare the roles of these two populations of innate immune cells. Finally, the current literature is framed in the context of developing therapies that manipulate the innate immune response to promote remyelination in clinical myelin disease. |
| first_indexed | 2024-12-22T01:35:39Z |
| format | Article |
| id | doaj.art-f926bfd5e2b946038b4cdb39727bb21a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T01:35:39Z |
| publishDate | 2016-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-f926bfd5e2b946038b4cdb39727bb21a2022-12-21T18:43:23ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2016-05-01410.3389/fcell.2016.00038195613CNS remyelination and the innate immune systemChristopher E McMurran0Clare A Jones1Denise C Fitzgerald2Robin J M Franklin3Wellcome Trust-Medical Research Council Cambridge Stem Cell InstituteMedImmuneCentre for Infection and ImmunityWellcome Trust-Medical Research Council Cambridge Stem Cell InstituteA misguided inflammatory response is frequently implicated in myelin damage. Particularly prominent among myelin diseases, multiple sclerosis (MS) is an autoimmune condition, with immune–mediated damage central to its aetiology. Nevertheless, a robust inflammatory response is also essential for the efficient regeneration of myelin sheaths after such injury. Here, we discuss the functions of inflammation that promote remyelination, and how these have been experimentally disentangled from the pathological facets of the immune response. We focus on the contributions that resident microglia and monocyte-derived macrophages make to remyelination and compare the roles of these two populations of innate immune cells. Finally, the current literature is framed in the context of developing therapies that manipulate the innate immune response to promote remyelination in clinical myelin disease.http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00038/fullInflammationMacrophagesMicrogliaInnate immune systemRemyelination. |
| spellingShingle | Christopher E McMurran Clare A Jones Denise C Fitzgerald Robin J M Franklin CNS remyelination and the innate immune system Frontiers in Cell and Developmental Biology Inflammation Macrophages Microglia Innate immune system Remyelination. |
| title | CNS remyelination and the innate immune system |
| title_full | CNS remyelination and the innate immune system |
| title_fullStr | CNS remyelination and the innate immune system |
| title_full_unstemmed | CNS remyelination and the innate immune system |
| title_short | CNS remyelination and the innate immune system |
| title_sort | cns remyelination and the innate immune system |
| topic | Inflammation Macrophages Microglia Innate immune system Remyelination. |
| url | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00038/full |
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