Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression
Master regulator transcription factors TP63 and SOX2 have been reported to overlap in genomic occupancy in squamous cell carcinomas (SCCs). Here, the authors demonstrate that TP63 and SOX2 promote co-operatively long non-coding RNA CCAT1 expression through activating its super-enhancer, and CCAT1 fo...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06081-9 |
| _version_ | 1818977769958146048 |
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| author | Yuan Jiang Yan-Yi Jiang Jian-Jun Xie Anand Mayakonda Masaharu Hazawa Li Chen Jin-Fen Xiao Chun-Quan Li Mo-Li Huang Ling-Wen Ding Qiao-Yang Sun Liang Xu Deepika Kanojia Maya Jeitany Jian-Wen Deng Lian-Di Liao Harmik J. Soukiasian Benjamin P. Berman Jia-Jie Hao Li-Yan Xu En-Min Li Ming-Rong Wang Xin-Gang Bi De-Chen Lin H. Phillip Koeffler |
| author_facet | Yuan Jiang Yan-Yi Jiang Jian-Jun Xie Anand Mayakonda Masaharu Hazawa Li Chen Jin-Fen Xiao Chun-Quan Li Mo-Li Huang Ling-Wen Ding Qiao-Yang Sun Liang Xu Deepika Kanojia Maya Jeitany Jian-Wen Deng Lian-Di Liao Harmik J. Soukiasian Benjamin P. Berman Jia-Jie Hao Li-Yan Xu En-Min Li Ming-Rong Wang Xin-Gang Bi De-Chen Lin H. Phillip Koeffler |
| author_sort | Yuan Jiang |
| collection | DOAJ |
| description | Master regulator transcription factors TP63 and SOX2 have been reported to overlap in genomic occupancy in squamous cell carcinomas (SCCs). Here, the authors demonstrate that TP63 and SOX2 promote co-operatively long non-coding RNA CCAT1 expression through activating its super-enhancer, and CCAT1 forms a complex with TP63 and SOX2, which regulates EGFR super-enhancers and enhances both the MEK/ERK1/2 and PI3K/AKT signaling pathways in SCC. |
| first_indexed | 2024-12-20T16:33:01Z |
| format | Article |
| id | doaj.art-f927ec3e43a241b38907cdd1a8dba8c5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:33:01Z |
| publishDate | 2018-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f927ec3e43a241b38907cdd1a8dba8c52022-12-21T19:33:13ZengNature PortfolioNature Communications2041-17232018-09-019111310.1038/s41467-018-06081-9Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progressionYuan Jiang0Yan-Yi Jiang1Jian-Jun Xie2Anand Mayakonda3Masaharu Hazawa4Li Chen5Jin-Fen Xiao6Chun-Quan Li7Mo-Li Huang8Ling-Wen Ding9Qiao-Yang Sun10Liang Xu11Deepika Kanojia12Maya Jeitany13Jian-Wen Deng14Lian-Di Liao15Harmik J. Soukiasian16Benjamin P. Berman17Jia-Jie Hao18Li-Yan Xu19En-Min Li20Ming-Rong Wang21Xin-Gang Bi22De-Chen Lin23H. Phillip Koeffler24Cancer Science Institute of Singapore, National University of SingaporeCancer Science Institute of Singapore, National University of SingaporeDepartment of Biochemistry and Molecular Biology, Medical College of Shantou UniversityCancer Science Institute of Singapore, National University of SingaporeCell-Bionomics Research Unit, Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Kanazawa UniversityDepartment of Medicine, Cedars-Sinai Medical CenterCancer Science Institute of Singapore, National University of SingaporeSchool of Medical Informatics, Daqing Campus, Harbin Medical UniversityCancer Science Institute of Singapore, National University of SingaporeCancer Science Institute of Singapore, National University of SingaporeCancer Science Institute of Singapore, National University of SingaporeCancer Science Institute of Singapore, National University of SingaporeCancer Science Institute of Singapore, National University of SingaporeCancer Science Institute of Singapore, National University of SingaporeDepartment of Biochemistry and Molecular Biology, Medical College of Shantou UniversityInstitute of Oncologic Pathology, Medical College of Shantou UniversityDepartment of Surgery, Cedars-Sinai Medical CenterCenter for Bioinformatics and Functional Genomics, Cedars-Sinai Medical CenterState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Oncologic Pathology, Medical College of Shantou UniversityDepartment of Biochemistry and Molecular Biology, Medical College of Shantou UniversityState Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Medicine, Cedars-Sinai Medical CenterCancer Science Institute of Singapore, National University of SingaporeMaster regulator transcription factors TP63 and SOX2 have been reported to overlap in genomic occupancy in squamous cell carcinomas (SCCs). Here, the authors demonstrate that TP63 and SOX2 promote co-operatively long non-coding RNA CCAT1 expression through activating its super-enhancer, and CCAT1 forms a complex with TP63 and SOX2, which regulates EGFR super-enhancers and enhances both the MEK/ERK1/2 and PI3K/AKT signaling pathways in SCC.https://doi.org/10.1038/s41467-018-06081-9 |
| spellingShingle | Yuan Jiang Yan-Yi Jiang Jian-Jun Xie Anand Mayakonda Masaharu Hazawa Li Chen Jin-Fen Xiao Chun-Quan Li Mo-Li Huang Ling-Wen Ding Qiao-Yang Sun Liang Xu Deepika Kanojia Maya Jeitany Jian-Wen Deng Lian-Di Liao Harmik J. Soukiasian Benjamin P. Berman Jia-Jie Hao Li-Yan Xu En-Min Li Ming-Rong Wang Xin-Gang Bi De-Chen Lin H. Phillip Koeffler Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression Nature Communications |
| title | Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression |
| title_full | Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression |
| title_fullStr | Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression |
| title_full_unstemmed | Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression |
| title_short | Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression |
| title_sort | co activation of super enhancer driven ccat1 by tp63 and sox2 promotes squamous cancer progression |
| url | https://doi.org/10.1038/s41467-018-06081-9 |
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