Prediction model for 30-day morbidity after gynecological malignancy surgery.
The potential risk of postoperative morbidity is important for gynecologic cancer patients because it leads to delays in adjunctive therapy and additional costs. We aimed to develop a preoperative nomogram to predict 30-day morbidity after gynecological cancer surgery.Between 2005 and 2015, 533 cons...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5453555?pdf=render |
| _version_ | 1818480382930059264 |
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| author | Seung-Hyuk Shim Sun Joo Lee Meari Dong Jung Hwa Suh Seo Yeon Kim Ji Hye Lee Soo-Nyung Kim Soon-Beom Kang Jayoun Kim |
| author_facet | Seung-Hyuk Shim Sun Joo Lee Meari Dong Jung Hwa Suh Seo Yeon Kim Ji Hye Lee Soo-Nyung Kim Soon-Beom Kang Jayoun Kim |
| author_sort | Seung-Hyuk Shim |
| collection | DOAJ |
| description | The potential risk of postoperative morbidity is important for gynecologic cancer patients because it leads to delays in adjunctive therapy and additional costs. We aimed to develop a preoperative nomogram to predict 30-day morbidity after gynecological cancer surgery.Between 2005 and 2015, 533 consecutive patients with elective gynecological cancer surgery in our center were reviewed. Of those patients, 373 and 160 patients were assigned to the model development or validation cohort, respectively. To investigate independent predictors of 30-day morbidity, a multivariate Cox regression model with backward stepwise elimination was utilized. A nomogram based on this Cox model was developed and externally validated. Its performance was assessed using the concordance index and a calibration curve.Ninety-seven (18.2%) patients had at least one postoperative complication within 30 days after surgery. After bootstrap resampling, the final model indicated age, operating time, and serum albumin level as statistically significant predictors of postoperative morbidity. The bootstrap-corrected concordance index of the nomogram incorporating these three predictors was 0.656 (95% CI, 0.608-0.723). In the validation cohort, the nomogram showed fair discrimination [concordance index: 0.674 (95% CI = 0.619-0.732] and good calibration (P = 0.614; Hosmer-Lemeshow test).The 30-day morbidity after gynecologic cancer surgery could be predicted according to age, operation time, and serum albumin level. After further validation using an independent dataset, the constructed nomogram could be valuable for predicting operative risk in individual patients. |
| first_indexed | 2024-12-10T11:22:46Z |
| format | Article |
| id | doaj.art-f92885881301403cb2328bb883191d94 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T11:22:46Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f92885881301403cb2328bb883191d942022-12-22T01:50:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017861010.1371/journal.pone.0178610Prediction model for 30-day morbidity after gynecological malignancy surgery.Seung-Hyuk ShimSun Joo LeeMeari DongJung Hwa SuhSeo Yeon KimJi Hye LeeSoo-Nyung KimSoon-Beom KangJayoun KimThe potential risk of postoperative morbidity is important for gynecologic cancer patients because it leads to delays in adjunctive therapy and additional costs. We aimed to develop a preoperative nomogram to predict 30-day morbidity after gynecological cancer surgery.Between 2005 and 2015, 533 consecutive patients with elective gynecological cancer surgery in our center were reviewed. Of those patients, 373 and 160 patients were assigned to the model development or validation cohort, respectively. To investigate independent predictors of 30-day morbidity, a multivariate Cox regression model with backward stepwise elimination was utilized. A nomogram based on this Cox model was developed and externally validated. Its performance was assessed using the concordance index and a calibration curve.Ninety-seven (18.2%) patients had at least one postoperative complication within 30 days after surgery. After bootstrap resampling, the final model indicated age, operating time, and serum albumin level as statistically significant predictors of postoperative morbidity. The bootstrap-corrected concordance index of the nomogram incorporating these three predictors was 0.656 (95% CI, 0.608-0.723). In the validation cohort, the nomogram showed fair discrimination [concordance index: 0.674 (95% CI = 0.619-0.732] and good calibration (P = 0.614; Hosmer-Lemeshow test).The 30-day morbidity after gynecologic cancer surgery could be predicted according to age, operation time, and serum albumin level. After further validation using an independent dataset, the constructed nomogram could be valuable for predicting operative risk in individual patients.http://europepmc.org/articles/PMC5453555?pdf=render |
| spellingShingle | Seung-Hyuk Shim Sun Joo Lee Meari Dong Jung Hwa Suh Seo Yeon Kim Ji Hye Lee Soo-Nyung Kim Soon-Beom Kang Jayoun Kim Prediction model for 30-day morbidity after gynecological malignancy surgery. PLoS ONE |
| title | Prediction model for 30-day morbidity after gynecological malignancy surgery. |
| title_full | Prediction model for 30-day morbidity after gynecological malignancy surgery. |
| title_fullStr | Prediction model for 30-day morbidity after gynecological malignancy surgery. |
| title_full_unstemmed | Prediction model for 30-day morbidity after gynecological malignancy surgery. |
| title_short | Prediction model for 30-day morbidity after gynecological malignancy surgery. |
| title_sort | prediction model for 30 day morbidity after gynecological malignancy surgery |
| url | http://europepmc.org/articles/PMC5453555?pdf=render |
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