Fracture healing research: Recent insights
Bone has the rare capability of scarless regeneration that enables the complete restoration of the injured bone area. In recent decades, promising new technologies have emerged from basic, translational and clinical research for fracture treatment; however, 5–10 % of all bone fractures still fail to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Bone Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187223000347 |
| _version_ | 1797398604170657792 |
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| author | Lena Steppe Michael Megafu Miriam E.A. Tschaffon-Müller Anita Ignatius Melanie Haffner-Luntzer |
| author_facet | Lena Steppe Michael Megafu Miriam E.A. Tschaffon-Müller Anita Ignatius Melanie Haffner-Luntzer |
| author_sort | Lena Steppe |
| collection | DOAJ |
| description | Bone has the rare capability of scarless regeneration that enables the complete restoration of the injured bone area. In recent decades, promising new technologies have emerged from basic, translational and clinical research for fracture treatment; however, 5–10 % of all bone fractures still fail to heal successfully or heal in a delayed manner. Several comorbidities and risk factors have been identified which impair bone healing and might lead to delayed bone union or non-union. Therefore, a considerable amount of research has been conducted to elucidate molecular mechanisms of successful and delayed fracture healing to gain further insights into this complex process. One focus of recent research is to investigate the complex interactions of different cell types and the action of progenitor cells during the healing process. Of particular interest is also the identification of patient-specific comorbidities and how these affect fracture healing. In this review, we discuss the recent knowledge about progenitor cells for long bone repair and the influence of comorbidities such as diabetes, postmenopausal osteoporosis, and chronic stress on the healing process. The topic selection for this review was made based on the presented studies at the 2022 annual meeting of the European Calcified Tissue Society (ECTS) in Helsinki. |
| first_indexed | 2024-03-09T01:27:57Z |
| format | Article |
| id | doaj.art-f9289ee49c4a457f9e8db6195dbca09b |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-03-09T01:27:57Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-f9289ee49c4a457f9e8db6195dbca09b2023-12-10T06:16:16ZengElsevierBone Reports2352-18722023-12-0119101686Fracture healing research: Recent insightsLena Steppe0Michael Megafu1Miriam E.A. Tschaffon-Müller2Anita Ignatius3Melanie Haffner-Luntzer4Institute of Orthopaedic Research and Biomechanics, University Medical Center Ulm, GermanyA.T. Still University Kirksville College of Osteopathic Medicine, USAInstitute of Orthopaedic Research and Biomechanics, University Medical Center Ulm, GermanyInstitute of Orthopaedic Research and Biomechanics, University Medical Center Ulm, GermanyInstitute of Orthopaedic Research and Biomechanics, University Medical Center Ulm, Germany; Corresponding author at: Helmholtzstraße 14, 89081 Ulm, Germany.Bone has the rare capability of scarless regeneration that enables the complete restoration of the injured bone area. In recent decades, promising new technologies have emerged from basic, translational and clinical research for fracture treatment; however, 5–10 % of all bone fractures still fail to heal successfully or heal in a delayed manner. Several comorbidities and risk factors have been identified which impair bone healing and might lead to delayed bone union or non-union. Therefore, a considerable amount of research has been conducted to elucidate molecular mechanisms of successful and delayed fracture healing to gain further insights into this complex process. One focus of recent research is to investigate the complex interactions of different cell types and the action of progenitor cells during the healing process. Of particular interest is also the identification of patient-specific comorbidities and how these affect fracture healing. In this review, we discuss the recent knowledge about progenitor cells for long bone repair and the influence of comorbidities such as diabetes, postmenopausal osteoporosis, and chronic stress on the healing process. The topic selection for this review was made based on the presented studies at the 2022 annual meeting of the European Calcified Tissue Society (ECTS) in Helsinki.http://www.sciencedirect.com/science/article/pii/S2352187223000347 |
| spellingShingle | Lena Steppe Michael Megafu Miriam E.A. Tschaffon-Müller Anita Ignatius Melanie Haffner-Luntzer Fracture healing research: Recent insights Bone Reports |
| title | Fracture healing research: Recent insights |
| title_full | Fracture healing research: Recent insights |
| title_fullStr | Fracture healing research: Recent insights |
| title_full_unstemmed | Fracture healing research: Recent insights |
| title_short | Fracture healing research: Recent insights |
| title_sort | fracture healing research recent insights |
| url | http://www.sciencedirect.com/science/article/pii/S2352187223000347 |
| work_keys_str_mv | AT lenasteppe fracturehealingresearchrecentinsights AT michaelmegafu fracturehealingresearchrecentinsights AT miriameatschaffonmuller fracturehealingresearchrecentinsights AT anitaignatius fracturehealingresearchrecentinsights AT melaniehaffnerluntzer fracturehealingresearchrecentinsights |