Field Efficacy of Topical Nano-Liposomal Amphotericin B (Sina Ampholeish®) Alone or in Combination with Glucantime® and Cryotherapy on Human Cutaneous Leishmaniasis
Background: Cutaneous leishmaniasis (CL) is a parasitic disease that presents a broad spectrum of clinical features. Treatment of CL is problematic. We aimed to compare the field therapeutic efficacy of topical nanoliposomes containing 0.4% amphotericin B (Nano Lip-AmB) alone and in combination wit...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-11-01
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| Series: | Iranian Journal of Parasitology |
| Subjects: | |
| Online Access: | https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3900 |
| _version_ | 1797394721733083136 |
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| author | Zahra Alizadeh Mohammad Reza Shirzadi Gholam Reza Hassanpour Hossein Keshavarz Fatemeh Mohebali Seyed Ebrahim Skandari Mohammad Zeinali Sedigheh Shirmohammad Mehdi Mohebali |
| author_facet | Zahra Alizadeh Mohammad Reza Shirzadi Gholam Reza Hassanpour Hossein Keshavarz Fatemeh Mohebali Seyed Ebrahim Skandari Mohammad Zeinali Sedigheh Shirmohammad Mehdi Mohebali |
| author_sort | Zahra Alizadeh |
| collection | DOAJ |
| description |
Background: Cutaneous leishmaniasis (CL) is a parasitic disease that presents a broad spectrum of clinical features. Treatment of CL is problematic. We aimed to compare the field therapeutic efficacy of topical nanoliposomes containing 0.4% amphotericin B (Nano Lip-AmB) alone and in combination with cryotherapy and/or Glucantime® on human CL in the endemic areas of Iran.
Methods: This retrospective study was performed based on the results of using Nano Lip-AmB alone or with Glucantime® and/or cryotherapy in the treatment of zoonotic cutaneous leishmaniasis (ZCL) in patients referred to health centers of Isfahan, Golestan and Ilam Provinces of Iran as endemic foci of ZCL caused by Leishmania major besides Mashhad and Bam cities as endemic foci of anthroponotic cutaneous leishmaniasis (ACL) caused by with L. tropica.
Results: Two hundred and seventy-eight patients with CL were included in the current study. All of the patients (100%) who received Nano Lip-AmB alone or in combination with Glucantime® and/or cryotherapy based on guideline of Iranian national committee for the treatment of CL. Two patients with 7 skin lesions, who was resident in ACL endemic area and received Nano Lip-AmB plus Glucantime® and another patient was a resident of ZCL endemic area and received Nano Lip-AmB plus cryotherapy showed clinical relapses after treatment.
Conclusion: Sina Ampholeish® in combination with other standard protocols of treatment of CL is well tolerated and with acceptable clinical efficacy rate.
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| first_indexed | 2024-03-09T00:23:51Z |
| format | Article |
| id | doaj.art-f9295b6ae4274abcb9dc3b905b3fad8b |
| institution | Directory Open Access Journal |
| issn | 1735-7020 2008-238X |
| language | English |
| last_indexed | 2024-03-09T00:23:51Z |
| publishDate | 2023-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Parasitology |
| spelling | doaj.art-f9295b6ae4274abcb9dc3b905b3fad8b2023-12-12T04:54:35ZengTehran University of Medical SciencesIranian Journal of Parasitology1735-70202008-238X2023-11-0118410.18502/ijpa.v18i4.14241Field Efficacy of Topical Nano-Liposomal Amphotericin B (Sina Ampholeish®) Alone or in Combination with Glucantime® and Cryotherapy on Human Cutaneous LeishmaniasisZahra Alizadeh0Mohammad Reza Shirzadi1Gholam Reza Hassanpour2Hossein Keshavarz3Fatemeh Mohebali4Seyed Ebrahim Skandari5Mohammad Zeinali6Sedigheh Shirmohammad7Mehdi Mohebali8Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, IranZoonoses Control Department, Center for Communicable Diseases Management, Ministry of Health and Medical Ed-ucation, Tehran, IranCenter for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, IranMaterials and Energy Research Center (MERC), Karaj, IranCenter for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, IranZoonoses Control Department, Center for Communicable Diseases Management, Ministry of Health and Medical Ed-ucation, Tehran, IranCenter for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran Background: Cutaneous leishmaniasis (CL) is a parasitic disease that presents a broad spectrum of clinical features. Treatment of CL is problematic. We aimed to compare the field therapeutic efficacy of topical nanoliposomes containing 0.4% amphotericin B (Nano Lip-AmB) alone and in combination with cryotherapy and/or Glucantime® on human CL in the endemic areas of Iran. Methods: This retrospective study was performed based on the results of using Nano Lip-AmB alone or with Glucantime® and/or cryotherapy in the treatment of zoonotic cutaneous leishmaniasis (ZCL) in patients referred to health centers of Isfahan, Golestan and Ilam Provinces of Iran as endemic foci of ZCL caused by Leishmania major besides Mashhad and Bam cities as endemic foci of anthroponotic cutaneous leishmaniasis (ACL) caused by with L. tropica. Results: Two hundred and seventy-eight patients with CL were included in the current study. All of the patients (100%) who received Nano Lip-AmB alone or in combination with Glucantime® and/or cryotherapy based on guideline of Iranian national committee for the treatment of CL. Two patients with 7 skin lesions, who was resident in ACL endemic area and received Nano Lip-AmB plus Glucantime® and another patient was a resident of ZCL endemic area and received Nano Lip-AmB plus cryotherapy showed clinical relapses after treatment. Conclusion: Sina Ampholeish® in combination with other standard protocols of treatment of CL is well tolerated and with acceptable clinical efficacy rate. https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3900Cutaneous leishmaniasisTreatmentSinaAmpholeish®Glucantime®CryotherapyHuman |
| spellingShingle | Zahra Alizadeh Mohammad Reza Shirzadi Gholam Reza Hassanpour Hossein Keshavarz Fatemeh Mohebali Seyed Ebrahim Skandari Mohammad Zeinali Sedigheh Shirmohammad Mehdi Mohebali Field Efficacy of Topical Nano-Liposomal Amphotericin B (Sina Ampholeish®) Alone or in Combination with Glucantime® and Cryotherapy on Human Cutaneous Leishmaniasis Iranian Journal of Parasitology Cutaneous leishmaniasis Treatment SinaAmpholeish® Glucantime® Cryotherapy Human |
| title | Field Efficacy of Topical Nano-Liposomal Amphotericin B (Sina Ampholeish®) Alone or in Combination with Glucantime® and Cryotherapy on Human Cutaneous Leishmaniasis |
| title_full | Field Efficacy of Topical Nano-Liposomal Amphotericin B (Sina Ampholeish®) Alone or in Combination with Glucantime® and Cryotherapy on Human Cutaneous Leishmaniasis |
| title_fullStr | Field Efficacy of Topical Nano-Liposomal Amphotericin B (Sina Ampholeish®) Alone or in Combination with Glucantime® and Cryotherapy on Human Cutaneous Leishmaniasis |
| title_full_unstemmed | Field Efficacy of Topical Nano-Liposomal Amphotericin B (Sina Ampholeish®) Alone or in Combination with Glucantime® and Cryotherapy on Human Cutaneous Leishmaniasis |
| title_short | Field Efficacy of Topical Nano-Liposomal Amphotericin B (Sina Ampholeish®) Alone or in Combination with Glucantime® and Cryotherapy on Human Cutaneous Leishmaniasis |
| title_sort | field efficacy of topical nano liposomal amphotericin b sina ampholeish r alone or in combination with glucantime r and cryotherapy on human cutaneous leishmaniasis |
| topic | Cutaneous leishmaniasis Treatment SinaAmpholeish® Glucantime® Cryotherapy Human |
| url | https://ijpa.tums.ac.ir/index.php/ijpa/article/view/3900 |
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