Moving towards Personalized Medicine—The Broad Use of Aptamers for Targeted Theranostic
Aptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodie...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/21/11933 |
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| author | André P. Sousa Ana C. Rocha Cátia Almeida Mariana C. C. G. Carneiro Patrick P. Pais Rejane Viana Rúben Fernandes Pedro Barata Álvaro Gestoso Susana Ramalho Daniela Martins-Mendes Pilar Baylina Ana Cláudia Pereira |
| author_facet | André P. Sousa Ana C. Rocha Cátia Almeida Mariana C. C. G. Carneiro Patrick P. Pais Rejane Viana Rúben Fernandes Pedro Barata Álvaro Gestoso Susana Ramalho Daniela Martins-Mendes Pilar Baylina Ana Cláudia Pereira |
| author_sort | André P. Sousa |
| collection | DOAJ |
| description | Aptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage identification and poor prognosis, like pancreatic cancer, the study of novel aptamers holds tremendous potential for cancer diagnosis and treatment. Along with cancer treatment, aptamers have also shown high potential in regulating the immune response and modulating several critical steps of signaling cascades, such as in immune checkpoints. In the context of microbiota and infection, aptamers are being studied to identify microbes and their metabolites. This assessment has the potential to improve the detection and management of infectious diseases while assisting us in better understanding health risks and treatment outcomes by tracking changes in the microbiota. In this review, the potential of aptamers is explored regarding their applications in cancer, immune, and microbiota therapy. |
| first_indexed | 2024-03-11T11:34:10Z |
| format | Article |
| id | doaj.art-f92a0578f4474cbfadc761e63713c8f2 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T11:34:10Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-f92a0578f4474cbfadc761e63713c8f22023-11-10T14:59:12ZengMDPI AGApplied Sciences2076-34172023-10-0113211193310.3390/app132111933Moving towards Personalized Medicine—The Broad Use of Aptamers for Targeted TheranosticAndré P. Sousa0Ana C. Rocha1Cátia Almeida2Mariana C. C. G. Carneiro3Patrick P. Pais4Rejane Viana5Rúben Fernandes6Pedro Barata7Álvaro Gestoso8Susana Ramalho9Daniela Martins-Mendes10Pilar Baylina11Ana Cláudia Pereira12HE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalHE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalHE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalBioMark Sensor Research/ISEP, School of Engineering, Polytechnic Institute, 4249-015 Porto, PortugalHE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalI3S—Instituto de Investigação e Inovação em Saúde, 4200-135 Porto, PortugalHE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalHE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalHE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalHE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalHE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalHE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalHE-FP—Hospital Fernando Pessoa, CECLIN—Center of Clinical Studies, 4420-096 Gondomar, PortugalAptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage identification and poor prognosis, like pancreatic cancer, the study of novel aptamers holds tremendous potential for cancer diagnosis and treatment. Along with cancer treatment, aptamers have also shown high potential in regulating the immune response and modulating several critical steps of signaling cascades, such as in immune checkpoints. In the context of microbiota and infection, aptamers are being studied to identify microbes and their metabolites. This assessment has the potential to improve the detection and management of infectious diseases while assisting us in better understanding health risks and treatment outcomes by tracking changes in the microbiota. In this review, the potential of aptamers is explored regarding their applications in cancer, immune, and microbiota therapy.https://www.mdpi.com/2076-3417/13/21/11933aptamercancerimmune responsemicrobiotaSELEXtherapeutic |
| spellingShingle | André P. Sousa Ana C. Rocha Cátia Almeida Mariana C. C. G. Carneiro Patrick P. Pais Rejane Viana Rúben Fernandes Pedro Barata Álvaro Gestoso Susana Ramalho Daniela Martins-Mendes Pilar Baylina Ana Cláudia Pereira Moving towards Personalized Medicine—The Broad Use of Aptamers for Targeted Theranostic Applied Sciences aptamer cancer immune response microbiota SELEX therapeutic |
| title | Moving towards Personalized Medicine—The Broad Use of Aptamers for Targeted Theranostic |
| title_full | Moving towards Personalized Medicine—The Broad Use of Aptamers for Targeted Theranostic |
| title_fullStr | Moving towards Personalized Medicine—The Broad Use of Aptamers for Targeted Theranostic |
| title_full_unstemmed | Moving towards Personalized Medicine—The Broad Use of Aptamers for Targeted Theranostic |
| title_short | Moving towards Personalized Medicine—The Broad Use of Aptamers for Targeted Theranostic |
| title_sort | moving towards personalized medicine the broad use of aptamers for targeted theranostic |
| topic | aptamer cancer immune response microbiota SELEX therapeutic |
| url | https://www.mdpi.com/2076-3417/13/21/11933 |
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