In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer

Current treatment regimens for pancreatic ductal adenocarcinoma (PDAC) yield poor 5-year survival, emphasizing the critical need to identify druggable targets essential for PDAC maintenance. We developed an unbiased and in vivo target discovery approach to identify molecular vulnerabilities in low-p...

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Bibliographic Details
Main Authors: Alessandro Carugo, Giannicola Genovese, Sahil Seth, Luigi Nezi, Johnathon Lynn Rose, Daniela Bossi, Angelo Cicalese, Parantu Krushnakant Shah, Andrea Viale, Piergiorgio Francesco Pettazzoni, Kadir Caner Akdemir, Christopher Aaron Bristow, Frederick Scott Robinson, James Tepper, Nora Sanchez, Sonal Gupta, Marcos Roberto Estecio, Virginia Giuliani, Gaetano Ivan Dellino, Laura Riva, Wantong Yao, Maria Emilia Di Francesco, Tessa Green, Carolina D’Alesio, Denise Corti, Ya’an Kang, Philip Jones, Huamin Wang, Jason Bates Fleming, Anirban Maitra, Pier Giuseppe Pelicci, Lynda Chin, Ronald Anthony DePinho, Luisa Lanfrancone, Timothy Paul Heffernan, Giulio Francesco Draetta
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306611

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