ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol
Abstract Background Emerging evidence points at substantial comorbidity between adult attention deficit hyperactivity disorder (ADHD) and cardiometabolic diseases, but our understanding of the comorbidity and how to manage cardiometabolic disease in adults with ADHD is limited. The ADHD Remote Techn...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-022-04429-6 |
| _version_ | 1797977377609875456 |
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| author | Hayley Denyer J Antoni Ramos-Quiroga Amos Folarin Carolina Ramos Petra Nemeth Andrea Bilbow Euan Woodward Susannah Whitwell Ulrich Müller-Sedgwick Henrik Larsson Richard JB Dobson Jonna Kuntsi |
| author_facet | Hayley Denyer J Antoni Ramos-Quiroga Amos Folarin Carolina Ramos Petra Nemeth Andrea Bilbow Euan Woodward Susannah Whitwell Ulrich Müller-Sedgwick Henrik Larsson Richard JB Dobson Jonna Kuntsi |
| author_sort | Hayley Denyer |
| collection | DOAJ |
| description | Abstract Background Emerging evidence points at substantial comorbidity between adult attention deficit hyperactivity disorder (ADHD) and cardiometabolic diseases, but our understanding of the comorbidity and how to manage cardiometabolic disease in adults with ADHD is limited. The ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA) project uses remote measurement technology to obtain real-world data from daily life to assess the extent to which ADHD medication treatment and physical activity, individually and jointly, may influence cardiometabolic risks in adults with ADHD. Our second main aim is to obtain valuable real-world data on adherence to pharmacological treatment and its predictors and correlates during daily life from adults with ADHD. Methods ART-CARMA is a multi-site prospective cohort study within the EU-funded collaboration ‘TIMESPAN’ (Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients) that will recruit 300 adults from adult ADHD waiting lists. The participants will be monitored remotely over a period of 12 months that starts from pre-treatment initiation. Passive monitoring, which involves the participants wearing a wrist-worn device (EmbracePlus) and downloading the RADAR-base Passive App and the Empatica Care App on their smartphone, provides ongoing data collection on a wide range of variables, such as physical activity, sleep, pulse rate (PR) and pulse rate variability (PRV), systolic peaks, electrodermal activity (EDA), oxygen saturation (SpO2), peripheral temperature, smartphone usage including social connectivity, and the environment (e.g. ambient noise, light levels, relative location). By combining data across these variables measured, processes such as physical activity, sleep, autonomic arousal, and indicators of cardiovascular health can be captured. Active remote monitoring involves the participant completing tasks using a smartphone app (such as completing clinical questionnaires or speech tasks), measuring their blood pressure and weight, or using a PC/laptop (cognitive tasks). The ART system is built on the RADAR-base mobile-health platform. Discussion The long-term goal is to use these data to improve the management of cardiometabolic disease in adults with ADHD, and to improve ADHD medication treatment adherence and the personalisation of treatment. |
| first_indexed | 2024-04-11T05:05:54Z |
| format | Article |
| id | doaj.art-f92a750493494f0daa40e8e4f33c88cc |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-11T05:05:54Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-f92a750493494f0daa40e8e4f33c88cc2022-12-25T12:24:47ZengBMCBMC Psychiatry1471-244X2022-12-0122111310.1186/s12888-022-04429-6ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocolHayley Denyer0J Antoni Ramos-Quiroga1Amos Folarin2Carolina Ramos3Petra Nemeth4Andrea Bilbow5Euan Woodward6Susannah Whitwell7Ulrich Müller-Sedgwick8Henrik Larsson9Richard JB Dobson10Jonna Kuntsi11Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonDepartment of Psychiatry, Hospital Universitari Vall d’HebronDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonGroup of Psychiatry, Mental Health and Addictions, Vall d’Hebron Research Institute (VHIR)Empatica SrlThe National Attention Deficit Disorder Information and Support Service, ADDISSEuropean Association for the Study of Obesity – IrelandSouth London and Maudsley NHS Foundation TrustAdult Neurodevelopmental Service, Health and Community Services, Government of JerseyDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetDepartment of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College LondonAbstract Background Emerging evidence points at substantial comorbidity between adult attention deficit hyperactivity disorder (ADHD) and cardiometabolic diseases, but our understanding of the comorbidity and how to manage cardiometabolic disease in adults with ADHD is limited. The ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA) project uses remote measurement technology to obtain real-world data from daily life to assess the extent to which ADHD medication treatment and physical activity, individually and jointly, may influence cardiometabolic risks in adults with ADHD. Our second main aim is to obtain valuable real-world data on adherence to pharmacological treatment and its predictors and correlates during daily life from adults with ADHD. Methods ART-CARMA is a multi-site prospective cohort study within the EU-funded collaboration ‘TIMESPAN’ (Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients) that will recruit 300 adults from adult ADHD waiting lists. The participants will be monitored remotely over a period of 12 months that starts from pre-treatment initiation. Passive monitoring, which involves the participants wearing a wrist-worn device (EmbracePlus) and downloading the RADAR-base Passive App and the Empatica Care App on their smartphone, provides ongoing data collection on a wide range of variables, such as physical activity, sleep, pulse rate (PR) and pulse rate variability (PRV), systolic peaks, electrodermal activity (EDA), oxygen saturation (SpO2), peripheral temperature, smartphone usage including social connectivity, and the environment (e.g. ambient noise, light levels, relative location). By combining data across these variables measured, processes such as physical activity, sleep, autonomic arousal, and indicators of cardiovascular health can be captured. Active remote monitoring involves the participant completing tasks using a smartphone app (such as completing clinical questionnaires or speech tasks), measuring their blood pressure and weight, or using a PC/laptop (cognitive tasks). The ART system is built on the RADAR-base mobile-health platform. Discussion The long-term goal is to use these data to improve the management of cardiometabolic disease in adults with ADHD, and to improve ADHD medication treatment adherence and the personalisation of treatment.https://doi.org/10.1186/s12888-022-04429-6Attention deficit hyperactivity disorderADHDCardiovascular diseaseMedication adherencemHealthRemote measurement technology |
| spellingShingle | Hayley Denyer J Antoni Ramos-Quiroga Amos Folarin Carolina Ramos Petra Nemeth Andrea Bilbow Euan Woodward Susannah Whitwell Ulrich Müller-Sedgwick Henrik Larsson Richard JB Dobson Jonna Kuntsi ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol BMC Psychiatry Attention deficit hyperactivity disorder ADHD Cardiovascular disease Medication adherence mHealth Remote measurement technology |
| title | ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol |
| title_full | ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol |
| title_fullStr | ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol |
| title_full_unstemmed | ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol |
| title_short | ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol |
| title_sort | adhd remote technology study of cardiometabolic risk factors and medication adherence art carma a multi centre prospective cohort study protocol |
| topic | Attention deficit hyperactivity disorder ADHD Cardiovascular disease Medication adherence mHealth Remote measurement technology |
| url | https://doi.org/10.1186/s12888-022-04429-6 |
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