Relationship between Serum Protein Electrophoresis, Endoscopic and Histopathological Scores in 99 Cats with Chronic Enteropathy
Few studies have investigated total protein (TP) and serum protein electrophoresis (SPE) in cats with chronic enteropathy (CE). Cats diagnosed with CE were evaluated to investigate the relationships between TP, SPE and endoscopy, histopathology, and extraintestinal involvement. Medical records were...
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MDPI AG
2022-08-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/9/453 |
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| author | Alessio Pierini Eleonora Gori Fiorenza Tulone Elena Benvenuti Enrico Bottero Pietro Ruggiero Veronica Marchetti |
| author_facet | Alessio Pierini Eleonora Gori Fiorenza Tulone Elena Benvenuti Enrico Bottero Pietro Ruggiero Veronica Marchetti |
| author_sort | Alessio Pierini |
| collection | DOAJ |
| description | Few studies have investigated total protein (TP) and serum protein electrophoresis (SPE) in cats with chronic enteropathy (CE). Cats diagnosed with CE were evaluated to investigate the relationships between TP, SPE and endoscopy, histopathology, and extraintestinal involvement. Medical records were searched for cats with a history of chronic gastrointestinal signs and a final diagnosis of CE. Information on signalment, TP, SPE, endoscopic score, histopathological diagnosis and score, and concurrent hepatic or pancreatic ultrasonographic alterations was collected. Relationships between protein profiles and other variables were investigated. Ninety-nine cats were included in the study, 63 diagnosed with various degrees of bowel inflammation and 36 with small-cell alimentary lymphoma. The most common TP alteration was hypoproteinemia (24%). No significant differences were observed between protein profiles and endoscopic and histopathological severity scores. Forty-five cats showing concurrent pancreatic and/or hepatic ultrasonographic alterations, had significantly lower albumin, lower α-globulin, and higher γ-globulin levels than cats not showing concurrent alterations. Disease severity scores did not seem to influence the protein profile in cats with CE. Extraintestinal involvement may be suspected in cats with lower albumin and α-globulins and higher γ-globulins. |
| first_indexed | 2024-03-09T22:15:49Z |
| format | Article |
| id | doaj.art-f92aaaab1d7b452ab236338655282bf1 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T22:15:49Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-f92aaaab1d7b452ab236338655282bf12023-11-23T19:23:39ZengMDPI AGVeterinary Sciences2306-73812022-08-019945310.3390/vetsci9090453Relationship between Serum Protein Electrophoresis, Endoscopic and Histopathological Scores in 99 Cats with Chronic EnteropathyAlessio Pierini0Eleonora Gori1Fiorenza Tulone2Elena Benvenuti3Enrico Bottero4Pietro Ruggiero5Veronica Marchetti6Department of Veterinary Science, University of Pisa, Via livornese, San Piero a Grado, 56122 Pisa, ItalyDepartment of Veterinary Science, University of Pisa, Via livornese, San Piero a Grado, 56122 Pisa, ItalyDepartment of Veterinary Science, University of Pisa, Via livornese, San Piero a Grado, 56122 Pisa, ItalyProfessional Association Endovet, 00149 Rome, ItalyProfessional Association Endovet, 00149 Rome, ItalyProfessional Association Endovet, 00149 Rome, ItalyDepartment of Veterinary Science, University of Pisa, Via livornese, San Piero a Grado, 56122 Pisa, ItalyFew studies have investigated total protein (TP) and serum protein electrophoresis (SPE) in cats with chronic enteropathy (CE). Cats diagnosed with CE were evaluated to investigate the relationships between TP, SPE and endoscopy, histopathology, and extraintestinal involvement. Medical records were searched for cats with a history of chronic gastrointestinal signs and a final diagnosis of CE. Information on signalment, TP, SPE, endoscopic score, histopathological diagnosis and score, and concurrent hepatic or pancreatic ultrasonographic alterations was collected. Relationships between protein profiles and other variables were investigated. Ninety-nine cats were included in the study, 63 diagnosed with various degrees of bowel inflammation and 36 with small-cell alimentary lymphoma. The most common TP alteration was hypoproteinemia (24%). No significant differences were observed between protein profiles and endoscopic and histopathological severity scores. Forty-five cats showing concurrent pancreatic and/or hepatic ultrasonographic alterations, had significantly lower albumin, lower α-globulin, and higher γ-globulin levels than cats not showing concurrent alterations. Disease severity scores did not seem to influence the protein profile in cats with CE. Extraintestinal involvement may be suspected in cats with lower albumin and α-globulins and higher γ-globulins.https://www.mdpi.com/2306-7381/9/9/453electrophoresiscatschronic enteropathyendoscopygamma-globulins |
| spellingShingle | Alessio Pierini Eleonora Gori Fiorenza Tulone Elena Benvenuti Enrico Bottero Pietro Ruggiero Veronica Marchetti Relationship between Serum Protein Electrophoresis, Endoscopic and Histopathological Scores in 99 Cats with Chronic Enteropathy Veterinary Sciences electrophoresis cats chronic enteropathy endoscopy gamma-globulins |
| title | Relationship between Serum Protein Electrophoresis, Endoscopic and Histopathological Scores in 99 Cats with Chronic Enteropathy |
| title_full | Relationship between Serum Protein Electrophoresis, Endoscopic and Histopathological Scores in 99 Cats with Chronic Enteropathy |
| title_fullStr | Relationship between Serum Protein Electrophoresis, Endoscopic and Histopathological Scores in 99 Cats with Chronic Enteropathy |
| title_full_unstemmed | Relationship between Serum Protein Electrophoresis, Endoscopic and Histopathological Scores in 99 Cats with Chronic Enteropathy |
| title_short | Relationship between Serum Protein Electrophoresis, Endoscopic and Histopathological Scores in 99 Cats with Chronic Enteropathy |
| title_sort | relationship between serum protein electrophoresis endoscopic and histopathological scores in 99 cats with chronic enteropathy |
| topic | electrophoresis cats chronic enteropathy endoscopy gamma-globulins |
| url | https://www.mdpi.com/2306-7381/9/9/453 |
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