Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis
Checkpoint blocking therapies are used to treat metastatic melanoma, but can have adverse immune-mediated effects, including liver pathology. Here the authors identify an expanded pool of CD4+ effector memory T cells resulting from prior CMV exposure as a risk factor for this adverse effect in these...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21572-y |
| _version_ | 1818681299389382656 |
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| author | James A. Hutchinson Katharina Kronenberg Paloma Riquelme Jürgen J. Wenzel Gunther Glehr Hannah-Lou Schilling Florian Zeman Katja Evert Martin Schmiedel Marion Mickler Konstantin Drexler Florian Bitterer Laura Cordero Lukas Beyer Christian Bach Josef Koestler Ralph Burkhardt Hans J. Schlitt Dirk Hellwig Jens M. Werner Rainer Spang Barbara Schmidt Edward K. Geissler Sebastian Haferkamp |
| author_facet | James A. Hutchinson Katharina Kronenberg Paloma Riquelme Jürgen J. Wenzel Gunther Glehr Hannah-Lou Schilling Florian Zeman Katja Evert Martin Schmiedel Marion Mickler Konstantin Drexler Florian Bitterer Laura Cordero Lukas Beyer Christian Bach Josef Koestler Ralph Burkhardt Hans J. Schlitt Dirk Hellwig Jens M. Werner Rainer Spang Barbara Schmidt Edward K. Geissler Sebastian Haferkamp |
| author_sort | James A. Hutchinson |
| collection | DOAJ |
| description | Checkpoint blocking therapies are used to treat metastatic melanoma, but can have adverse immune-mediated effects, including liver pathology. Here the authors identify an expanded pool of CD4+ effector memory T cells resulting from prior CMV exposure as a risk factor for this adverse effect in these patients. |
| first_indexed | 2024-12-17T10:00:44Z |
| format | Article |
| id | doaj.art-f92b658607e1458c8aa40adb3861c519 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:00:44Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f92b658607e1458c8aa40adb3861c5192022-12-21T21:53:18ZengNature PortfolioNature Communications2041-17232021-03-0112111510.1038/s41467-021-21572-yVirus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitisJames A. Hutchinson0Katharina Kronenberg1Paloma Riquelme2Jürgen J. Wenzel3Gunther Glehr4Hannah-Lou Schilling5Florian Zeman6Katja Evert7Martin Schmiedel8Marion Mickler9Konstantin Drexler10Florian Bitterer11Laura Cordero12Lukas Beyer13Christian Bach14Josef Koestler15Ralph Burkhardt16Hans J. Schlitt17Dirk Hellwig18Jens M. Werner19Rainer Spang20Barbara Schmidt21Edward K. Geissler22Sebastian Haferkamp23Department of Surgery, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgInstitute of Clinical Microbiology and Hygiene, University Hospital RegensburgInstitute of Functional Genomics and Statistical Bioinformatics, University of RegensburgDepartment of Surgery, University Hospital RegensburgCenter for Clinical Studies, University Hospital RegensburgInstitute of Pathology, University Hospital RegensburgDepartment of Nuclear Medicine, University Hospital RegensburgDepartment of Dermatology, University Hospital RegensburgDepartment of Dermatology, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgInstitute of Radiology, University Hospital RegensburgDepartment of Medicine V, University Hospital ErlangenInstitute of Clinical Microbiology and Hygiene, University Hospital RegensburgInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgDepartment of Nuclear Medicine, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgInstitute of Functional Genomics and Statistical Bioinformatics, University of RegensburgInstitute of Clinical Microbiology and Hygiene, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgDepartment of Dermatology, University Hospital RegensburgCheckpoint blocking therapies are used to treat metastatic melanoma, but can have adverse immune-mediated effects, including liver pathology. Here the authors identify an expanded pool of CD4+ effector memory T cells resulting from prior CMV exposure as a risk factor for this adverse effect in these patients.https://doi.org/10.1038/s41467-021-21572-y |
| spellingShingle | James A. Hutchinson Katharina Kronenberg Paloma Riquelme Jürgen J. Wenzel Gunther Glehr Hannah-Lou Schilling Florian Zeman Katja Evert Martin Schmiedel Marion Mickler Konstantin Drexler Florian Bitterer Laura Cordero Lukas Beyer Christian Bach Josef Koestler Ralph Burkhardt Hans J. Schlitt Dirk Hellwig Jens M. Werner Rainer Spang Barbara Schmidt Edward K. Geissler Sebastian Haferkamp Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis Nature Communications |
| title | Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis |
| title_full | Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis |
| title_fullStr | Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis |
| title_full_unstemmed | Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis |
| title_short | Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis |
| title_sort | virus specific memory t cell responses unmasked by immune checkpoint blockade cause hepatitis |
| url | https://doi.org/10.1038/s41467-021-21572-y |
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