Identification of DNA Methyltransferase-1 Inhibitor for Breast Cancer Therapy through Computational Fragment-Based Drug Design

Identification of DNA Methyltransferase-1 Inhibitor for Breast Cancer Therapy through Computational Fragment-Based Drug Design

Epimutation by DNA Methyltransferase 1 (DNMT1), an epigenetic regulator enzyme, may lead to the proliferation of breast cancer. In this report, 168,686 natural products from the PubChem database were screened and modified by in silico method to acquire the potential inhibitor of DNMT1. The initial s...

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Bibliographic Details
Main Authors: Ahmad Husein Alkaff, Mutiara Saragih, Shabrina Noor Imana, Mochammad Arfin Fardiansyah Nasution, Usman Sumo Friend Tambunan
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
dengue
envelope protein
natural product
fragment growing
molecular docking simulation
Online Access:https://www.mdpi.com/1420-3049/26/2/375

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